A5026554450- Glioma Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Radiotherapy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Neural dynamics and brain function
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Virus-based gene therapy research
- S100 Proteins and Annexins
- Molecular Communication and Nanonetworks
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury Research
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- interferon and immune responses
- Brain Tumor Detection and Classification
- Advanced Electron Microscopy Techniques and Applications
Aarhus University
2007-2024
Aarhus University Hospital
2016-2024
Copenhagen University Hospital
2024
Odense University Hospital
2018-2019
University of Southern Denmark
2019
Novocure (United States)
2016
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to high diversity more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology single-cell RNA sequencing) sampling in human brain slices was used reliably target and analyze individual This characterization elucidated transitions between PVALB SST subclasses, morphological heterogeneity within...
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier clinical effectiveness, as resistance this treatment can occur through the inhibition viral spread within tumor, potentially leading failures. Here we show that 4-octyl itaconate (4-OI), chemical derivative Krebs cycle-derived metabolite itaconate, enhances with VSVΔ51 various models including human and murine resistant cancer cell lines, three-dimensional (3D) patient-derived colon tumoroids...
Tumor treating fields (TTFields) are increasingly used in the treatment of glioblastoma. TTFields inhibit cancer growth through induction alternating electrical fields. To optimize efficacy, it is necessary to understand factors determining strength and distribution TTFields. In this study, we provide simple guiding principles for clinicians assess local efficacy various clinical scenarios.We calculated using finite element methods applied a realistic head model. Dielectric property...
Tumor treating fields (TTFields) is a new modality used for the treatment of glioblastoma. It based on antineoplastic low-intensity electric induced by two pairs electrode arrays placed patient's scalp. The layout greatly impacts intensity (dose) TTFields in pathology. present study systematically characterizes impact array position distribution calculated realistic human head model using finite element methods. We investigate systematic rotations around central craniocaudal axis and...
Introduction Vasopressor support is often preferred as an efficient and convenient way to raise the blood pressure during surgery intensive care therapy. However, optimal vasopressor for ensuring organ flow tissue oxygen delivery remains undetermined. This study aims assess impact of norepinephrine versus phenylephrine on cerebral non-cerebral perfusion oxygenation anaesthesia in neurosurgical patients with brain tumours. The also explores agents distribution cardiac output between various...
The present work proposes a new clinical approach to TTFields therapy of glioblastoma. combines targeted surgical skull removal (craniectomy) with enhance the induced electrical field in underlying tumor tissue. Using computer simulations, we explore potential intervention improve efficacy brain cancer.We used finite element analysis calculate distribution realistic head models based on MRI data from two patients: One left cortical/subcortical glioblastoma and one deeply seated right...
Maximal safe resection is an important surgical goal in the treatment for high-grade gliomas. Fluorescent dyes help surgeon to distinguish malignant tissue from healthy. The aims of this study were 1) compare 2 fluorescent 5-aminolevulinic acid (5-ALA) and sodium fluorescein (fluorescein) regarding extent resection, progression-free survival, overall survival; 2) assess influence other risk factors on clinical outcome screen potential disadvantages dyes.
Abstract Background Preclinical studies suggest that skull remodeling surgery (SR-surgery) increases the dose of tumor treating fields (TTFields) in glioblastoma (GBM) and prevents wasteful current shunting through skin. SR-surgery introduces minor defects to focus cancer-inhibiting currents toward increase treatment dose. This study aimed test safety feasibility this concept a phase I setting. Methods Fifteen adult patients with first recurrence GBM were treated personalized SR-surgery,...
Summary Glioblastomas (GBM) are renowned for their pronounced intratumoral heterogeneity, characterized by a diverse array of plastic cell types, which poses significant challenge to effective targeting and treatment [1]. Recent research has documented the presence neuronal-progenitor-like transcriptomic states GBM [2, 3], notably in leading edge tumor, where synaptic input from adjacent neurons drives disease proliferation [4]. However, conflicting observations regarding excitability,...
Abstract Tumor-treating fields (TTFields) are currently a Category 1A treatment recommendation by the US National Comprehensive Cancer Center for patients with newly diagnosed glioblastoma. Although mechanism of action TTFields has been partly elucidated, tangible and standardized metrics lacking to assess antitumor dose effects treatment. This paper outlines evaluates current standards methodologies in estimation distribution measurement brain highlights most important principles governing...
Synapses in the cerebral cortex constantly change and this dynamic property regulated by action of neuromodulators such as dopamine (DA), is essential for reward learning memory. DA modulates spike-timing-dependent plasticity (STDP), a cellular model memory, juvenile rodent cortical neurons. However, it unknown whether neuromodulation also occurs at excitatory synapses neurons mature adult mice or humans. Cortical layer V pyramidal were recorded with whole cell patch clamp electrophysiology...
Tumor treating fields (TTFields) are increasingly used to treat newly diagnosed and recurrent glioblastoma (GBM). Recently, the authors proposed a new comprehensive method for efficacy estimation based on singular value decomposition of sequential field distributions. The accounts all parameters known affect anti-cancer TTFields, i.e. intensity, exposure time, spatial correlation. In this paper, we describe further development, which enables individual optimization TTFields activation cycle....
Background and purpose: Although picrotoxin is a well‐established antagonist of GABA A receptors, detailed studies its action on inhibitory synaptic transmission have not previously been made. Experimental approach: Electrophysiological techniques were used to study the postsynaptic currents (IPSCs) evoked in hippocampal neurones, culture slice preparations prepared from Wistar rat embryos juveniles, respectively. Key results: Picrotoxin gradually reduced amplitude receptor‐mediated eIPSCs...
Skull-remodeling surgery has been proposed to enhance the dose of tumor treating fields in glioblastoma treatment. This abstract describes finite element methods used plan and evaluate treatment efficacy.
Tumor treating fields (TTFields) is an anticancer treatment that inhibits tumor growth with alternating electrical fields. Finite element (FE) methods have been used to estimate the TTFields intensity as a measure of "dose". However, efficacy also depends on field direction and exposure time. Here we propose new FE based approach, which uses all these parameters quantify average amount unwanted directional correlation (fractional anisotropy, FA). The method principal component decomposition...
Tumor treating fields (TTFields) are increasingly used as a fourth modality in glioblastoma therapy. TTFields alternating electrical fields, which inhibit cancer growth by disrupting mitotic processes. Optimization of efficacy requires thorough understanding distribution “dose” the brain. Here we provide simple guiding principles, facilitate intuitive such distributions and impact technology. Our results based on extensive field modeling. We estimated realistic human head model using finite...
Intraoperative visual evoked potentials (VEPs) are used to monitor the function of optic radiation during neurosurgery with P100 amplitude decrement as a predictor post-operative deficit. However, there is currently no evidence early VEP changes indicating reversible field affection.In this case report, we VEPs surgery for benign meningioma located in atrium right lateral ventricle. The tumor was accessed through transcortical approach via two-centimeter corticotomy aspect superior parietal...