A5016511356- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- RNA Interference and Gene Delivery
- vaccines and immunoinformatics approaches
- Peptidase Inhibition and Analysis
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- Viral Infections and Vectors
- Complement system in diseases
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
Aarhus University
2023-2024
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier clinical effectiveness, as resistance this treatment can occur through the inhibition viral spread within tumor, potentially leading failures. Here we show that 4-octyl itaconate (4-OI), chemical derivative Krebs cycle-derived metabolite itaconate, enhances with VSVΔ51 various models including human and murine resistant cancer cell lines, three-dimensional (3D) patient-derived colon tumoroids...
Abstract The complement system which is part of the innate immune response against invading pathogens represents a powerful mechanism for killing infected cells. Utilizing direct recruitment complement‐mediated elimination HIV‐1‐infected cells underexplored. We developed novel therapeutic modality to activity surface This bispecific engager (BiCE) comprised nanobody recruiting complement‐initiating protein C1q, and single‐chain variable fragments broadly neutralizing antibodies (bNAbs)...
Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING activate innate immune functions. The best-studied downstream responses activation include expression of type I interferon and inflammatory genes, but also activates other pathways, including apoptosis. Here, we report that STING-dependent induction apoptosis in macrophages occurs the intrinsic mitochondrial pathway mediated via IRF3 acts independently gene transcription. By intersecting four mass spectrometry...
Despite development of effective SARS-CoV-2 vaccines, a sub-group vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases severe disease. However, perpetual viral evolution has required continuous efficacy monitoring as well exploration new antibodies, to circumvent resistance mutations arising the population. We performed SARS-CoV-2-specific B cell sorting and subsequent single-cell sequencing material from 15 convalescent participants. Through screening...
The oxidation status of N-terminal cysteines directly dictates protein stability via arginylation and proteasomal degradation. However, only a handful proteins have been shown to be regulated this pathway. To date, no methods detect cysteine reactivity abundance has reported. Here, we demonstrate, for the first time, that targeting probes can used in living cells bind quantify cysteines, discriminating their state. Using these probes, identify hundreds show changes under hypoxia detected. We...