A5083301588- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Acne and Rosacea Treatments and Effects
- Synthesis and biological activity
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Ocular Diseases and Behçet’s Syndrome
- Viral Infectious Diseases and Gene Expression in Insects
- Poxvirus research and outbreaks
- Immunodeficiency and Autoimmune Disorders
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
The Graduate Center, CUNY
2023
CUNY Advanced Science Research Center
2023
University of Florida
1971
Tilorone hydrochloride was studied in humans to determine whether it would be a safe and effective interferon inducer man. Both systemic topical application failed produce detectible interferon, toxicity noted using both routes of administration. This study indicates that even the high doses, tilorone HCl is neither nor effective.
Five cases of secondary and recurrent herpes simplex conjunctivitis without corneal involvement are presented. The disease may vary from an asymptomatic to a severe ulcerative disease. Each case was confirmed by isolation the virus, one patient demonstrated antigen in conjunctival tissue.
Adenovirus infection of man is common and some adenoviruses have been implicated as causative factors cancer in animals. Some types adenovirus produce sufficiently mild infections, however, so that volunteer studies with these agents appear relatively simple risk free (1,2). The testing drugs on randomly occurring diseases difficult, since a definite clinical diagnosis may not be possible until the disease past. In addition, variability cases, except very large epidemics, would require...
Despite development of effective SARS-CoV-2 vaccines, a sub-group vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases severe disease. However, perpetual viral evolution has required continuous efficacy monitoring as well exploration new antibodies, to circumvent resistance mutations arising the population. We performed SARS-CoV-2-specific B cell sorting and subsequent single-cell sequencing material from 15 convalescent participants. Through screening...