A5045496989- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
Aarhus University
2022-2023
Aarhus University Hospital
2023
Abstract The complement system which is part of the innate immune response against invading pathogens represents a powerful mechanism for killing infected cells. Utilizing direct recruitment complement‐mediated elimination HIV‐1‐infected cells underexplored. We developed novel therapeutic modality to activity surface This bispecific engager (BiCE) comprised nanobody recruiting complement‐initiating protein C1q, and single‐chain variable fragments broadly neutralizing antibodies (bNAbs)...
Despite development of effective SARS-CoV-2 vaccines, a sub-group vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases severe disease. However, perpetual viral evolution has required continuous efficacy monitoring as well exploration new antibodies, to circumvent resistance mutations arising the population. We performed SARS-CoV-2-specific B cell sorting and subsequent single-cell sequencing material from 15 convalescent participants. Through screening...
Abstract The complement system which is part of the innate immune response against invading pathogens, represents a powerful mechanism for killing infected cells. Utilizing direct recruitment complement-mediated elimination HIV-1-infected cells underexplored. We developed novel therapeutic modality to activity surface This bispecific engager (BiCE) comprised nanobody recruiting complement-initiating protein C1q, and single-chain variable fragments broadly neutralizing antibodies (bNAbs)...