A5013758206- Immune cells in cancer
- Virus-based gene therapy research
- interferon and immune responses
- Immune Cell Function and Interaction
- Polyamine Metabolism and Applications
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
- Immune Response and Inflammation
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatic function and diabetes
- Immune responses and vaccinations
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Family and Patient Care in Intensive Care Units
- Herpesvirus Infections and Treatments
- Viral Infections and Outbreaks Research
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Pediatric Pain Management Techniques
- Vaccine Coverage and Hesitancy
Trinity College Dublin
2020-2024
Max Planck Institute of Immunobiology and Epigenetics
2020-2021
The Royal Free Hospital
1993
University of Edinburgh
1993
University College London
1993
Columbia University Irving Medical Center
1988
New York University
1988
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but biological implications this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing ability CD4
Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one the leading causes mortality worldwide. Recently, type I interferon (IFN) signaling has been shown be required for tissue factor (TF; gene name F3) release from macrophages, critical initiator providing an important mechanistic link between innate immunity coagulation. The mechanism...
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier clinical effectiveness, as resistance this treatment can occur through the inhibition viral spread within tumor, potentially leading failures. Here we show that 4-octyl itaconate (4-OI), chemical derivative Krebs cycle-derived metabolite itaconate, enhances with VSVΔ51 various models including human and murine resistant cancer cell lines, three-dimensional (3D) patient-derived colon tumoroids...
ABSTRACT In recent years, especially since the outbreak of severe acute respiratory syndrome coronavirus 2 pandemic, cell-permeable itaconate derivative 4-octyl (4-OI) has gained traction as a potential antiviral agent. Here, we demonstrate that 4-OI inhibits replication multiple influenza A viruses (IAV) by restricting nuclear export viral ribonucleoproteins, key step in IAV cycle. This retention is achieved deactivation and subsequent degradation chromosomal maintenance 1 protein (CRM1),...
In the course of a series investigations designed for purpose establishing path absorption botulinus toxin in guinea pigs, number animals were kept under ether surgical manipulation. It was observed that such death following introduction greatly delayed. Whereas normal pigs 350 grams given 50,000 minimal lethal doses intraperitoneally show symptoms dyspnea one hour and invariably die about two hours, similarly injected but put anesthesia hours as soon occurs (i.e., after injection toxin)...
Some time ago we have observed the delay in rate of absorption botulinus toxin animals subjected to ether anesthesia. Combining anesthesia with specific serum therapy, been able save poisoned where antitoxin alone failed do so. In view fact that application cases poisoning men would be difficult on account pronounced respiratory distress present as a predominant symptom such cases, attempted find satisfactory substitute for Among various substances thus far tried degrees success, morphine...
SUMMARY We report here a central role for polyamines in T cell differentiation and function. Deficiency ornithine decarboxylase (ODC), critical enzyme polyamine synthesis, resulted profound failure of CD4 + cells to adopt correct subset specification, underscored by ectopic expression multiple cytokines lineage-defining transcription factors across H 1, 2, 17, reg polarizing conditions, enhanced colitogenic potential. deficient deoxyhypusine synthase (DHPS) or hydroxylase (DOHH), which...
<title>Abstract</title> Altered metabolism and defective innate immune responses are hallmarks of tumor cells, creating a niche that can be exploited by viruses with oncolytic properties. However, heterogeneity in to virotherapy is barrier clinical effectiveness. Resistance exists occurs via inhibition viral spread within the may result treatment failures. Here we show Krebs cycle-derived metabolite itaconate its chemical derivatives or natural isomers enhance VSVΔ51M various models...
It has become important to clarify whether genotypes of hepatitis C virus correlate with patho- genicity, infectivity, response antiviral treat- ment, and geographic clustering.We have analysed the pattern nucleotide sequence variability in 5 prime non-coding region (5'NCR) by restricting enzymes analyse distribution HCV 80 patients chronic C. Genotypes were correlated demographical, clinical, histological features.Biopsies coded as (1) mild or moderate without cirrhosis (2) severe...