A5010536269- Immune cells in cancer
- Inflammasome and immune disorders
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
- Phagocytosis and Immune Regulation
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Macrophage Migration Inhibitory Factor
- Iron Metabolism and Disorders
- Cytokine Signaling Pathways and Interactions
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Immune responses and vaccinations
- Diabetes and associated disorders
- RNA regulation and disease
Trinity College Dublin
2021-2024
Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one the leading causes mortality worldwide. Recently, type I interferon (IFN) signaling has been shown be required for tissue factor (TF; gene name F3) release from macrophages, critical initiator providing an important mechanistic link between innate immunity coagulation. The mechanism...
Mitochondria are intracellular membrane-bound organelles that harness the chemical energy in food to drive adenosine triphosphate (ATP) synthesis via oxidative phosphorylation. In last several decades, mitochondria have emerged as central signalling hubs regulating cellular fate and function beyond their appreciated role bioenergetics. This often requires release of mitochondrial-derived signals, such cytochrome C, metabolites reactive oxygen species, into cytosol, all which been linked cell...