A5018662372- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Galectins and Cancer Biology
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Glycosylation and Glycoproteins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Pulmonary Hypertension Research and Treatments
- Glutathione Transferases and Polymorphisms
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA regulation and disease
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
Medical University of Graz
2021-2025
Trinity College Dublin
2018-2022
University of Verona
2009-2019
General Department of Preventive Medicine
2015
Abstract Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for neurological autoimmune diseases; previous studies have shown that treatment with bone marrow-derived MSCs induces immune modulation and reduces disease severity in experimental encephalomyelitis (EAE), an animal model of multiple sclerosis. Here we show intravenous administration adipose-derived (ASCs) before onset significantly the EAE by decreases spinal cord inflammation demyelination. ASCs...
A variety of innate immune responses and functions are dependent on time day, many inflammatory conditions associated with dysfunctional molecular clocks within cells. However, the functional importance these has yet to be fully characterized. NRF2 plays a critical role in system, limiting inflammation via reactive oxygen species (ROS) suppression direct repression proinflammatory cytokines, IL-1β IL-6. Here we reveal that core clock protein, BMAL1, controls mRNA expression Nrf2 E-box...
Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation gene transcription and protein phosphorylation. been shown control macrophage metabolic remodeling inflammation, but its role T cell biology is poorly understood. Here, we report upregulation, phosphorylation, nuclear accumulation murine human CD4
Mesenchymal stem cells (MSCs) represent a promising therapeutic approach in nerve tissue engineering. To date, the local implantation of MSC injured nerves has been only route administration used. In case multiple sites injury, systemic capable reaching damaged would be advisable. this regard, we found that an intravenous adipose-derived (ASC) 1 week after sciatic crush murine model acute axonal damage, significantly accelerated functional recovery. Sciatic from ASC-treated mice showed...
The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β IL-18 promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), constitutive deglutathionylating enzyme, as regulator inflammasome. Using small molecule inhibitor GSTO1-1 termed C1-27, endogenous knockdown, GSTO1-1-/- mice, report that involved in...
Cell based-therapies represent promising strategies for the treatment of neurological diseases. We have previously shown that adipose stem cells (ASC) ameliorate chronic experimental autoimmune encephalomyelitis (EAE). Recent evidence indicates most ASC paracrine effects are mediated by extracellular vesicles, i.e. micro- and nanovesicles (MVs NVs). show preventive intravenous administration NVs isolated from (ASC-NVs) before disease onset significantly reduces severity EAE decreases spinal...
Cystic fibrosis (CF) is a common genetic disease caused by mutations of the cystic transmembrane conductance regulator (CFTR) gene. Persistent lung inflammation, characterized increasing polymorphonuclear leukocyte recruitment, major cause decline in respiratory function patients with CF and leading morbidity mortality. CFTR expressed various cell types, including leukocytes, but its involvement regulation recruitment unknown.We evaluated whether leukocytes might present alterations adhesion...
Regulatory T cells (Tregs) maintain tolerance toward self-antigens and suppress autoimmune diseases, although the underlying molecular mechanisms are unclear. In this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more severe form of experimental encephalomyelitis than wild type animals do, suggesting PSGL-1 has role in negative regulation autoimmunity. We found Tregs lacking were unable to failed inhibit cell proliferation vivo lymph nodes. Using...
Leukocyte trafficking is a key event during autoimmune and inflammatory responses. The leptomeninges cerebrospinal fluid are major routes for the migration of encephalitogenic T cells into central nervous system (CNS) experimental encephalomyelitis (EAE), animal model multiple sclerosis, sites cell activation before invasion CNS parenchyma. In particular, autoreactive Th1 Th17 reactivation in required pathogenesis EAE. However, molecular mechanisms controlling dynamics EAE unclear. We used...
Introduction: Idiopathic pulmonary fibrosis(IPF) is a chronic progressive lung disease that leads to destruction of alveoli and replacement by fibrotic tissue. Metabolic profiling tissue serum from IPF patients has revealed levels tricarboxylic acid (TCA) cycle metabolites such as succinate are altered in with IPF. In our study, we aim evaluate the role its receptor- receptor 1 (SUCNR1) pathogenesis fibrosis, focus on fibroblasts, central cell Methods: SUCNR1 expression was investigated...