A5017534619- Mesenchymal stem cell research
- Obesity, Physical Activity, Diet
- Consumer Attitudes and Food Labeling
- Nutritional Studies and Diet
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Nerve injury and regeneration
- COVID-19 and Mental Health
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Wound Healing and Treatments
- Diet, Metabolism, and Disease
- Mobile Health and mHealth Applications
- Nutrition, Genetics, and Disease
- Extracellular vesicles in disease
- Multiple Sclerosis Research Studies
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Pluripotent Stem Cells Research
- Parasites and Host Interactions
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Amyotrophic Lateral Sclerosis Research
University of Brescia
2020-2025
VisMederi Research
2021
Center for Translational Molecular Medicine
2020
University of Verona
2005-2015
Institute of Neurological Sciences
2006
Azienda Ospedaliera Universitaria Integrata Verona
2003-2005
Abstract Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for neurological autoimmune diseases; previous studies have shown that treatment with bone marrow-derived MSCs induces immune modulation and reduces disease severity in experimental encephalomyelitis (EAE), an animal model of multiple sclerosis. Here we show intravenous administration adipose-derived (ASCs) before onset significantly the EAE by decreases spinal cord inflammation demyelination. ASCs...
Adult mesenchymal stem cells derived from adipose tissue (A-MSC) have the capacity to differentiate in vitro into as well endodermal and ectodermal cell lineages. We investigated neuronal differentiation potential of human A-MSC with a protocol which included sphere formation sequential culture brain-derived neurotrophic factor (BDNF) retinoic acid (RA). After 30 days, about 57% showed morphological, immunocytochemical electrophysiological evidence initial differentiation. In fact, displayed...
Mesenchymal stem cells (MSCs) represent a promising therapeutic approach in nerve tissue engineering. To date, the local implantation of MSC injured nerves has been only route administration used. In case multiple sites injury, systemic capable reaching damaged would be advisable. this regard, we found that an intravenous adipose-derived (ASC) 1 week after sciatic crush murine model acute axonal damage, significantly accelerated functional recovery. Sciatic from ASC-treated mice showed...
Multiple sclerosis (MS)-associated retrovirus (MSRV)/HERV-W (human endogenous W) and Human herpesvirus 6 (HHV-6) are the two most studied (and discussed) viruses as environmental co-factors that trigger MS immunopathological phenomena. Autopsied brain tissues from patients controls peripheral blood mononuclear cells (PBMCs) were analysed. Quantitative RT-PCR PCR with primers specific for MSRV/HERV-W env pol HHV-6 U94/ rep DNA-pol used to determine virus copy numbers. Brain sections...
Lockdown measures during the recent pandemic, due to novel COVID-19, affected several other aspects of lifestyle, but little is known about their long-term impact, especially among adolescents. Our study aimed assess consequences changes in diet, exercise and screen activity levels, sleep quality, smoke, smartphone addiction emotional distress a sample Italian adolescents, 2 years after beginning pandemic.
The presence of autoantibodies in multiple sclerosis (MuS) is well known, but their target antigens have not been clearly identified. In the present study, IgG autoreactivity to neural normal human white matter separated by bidimensional electrophoresis was assessed serum and cerebrospinal fluid 18 MuS 20 control patients. Broad detected two-dimensional immunoblotting all cases antigens, most which were identified mass spectrometry. comparative analysis non-MuS reactive spots showed that a...
Background of the Study. Nonalcoholic fatty liver disease (NAFLD) is most common in western countries. Lifestyle interventions are recommended as primary therapy for NAFLD. Methodology. In this clinical trial, NAFLD patients were enrolled a 12-month dietary intervention aimed to improve their eating habits according Mediterranean pattern, with scheduled appointments every three months. After exclusion steatosis, healthy subjects recruited and received general advice based on current Italian...
Background/Objectives: Regular consumption of dietary fiber (DF) has been associated with non-communicable disease prevention and health benefits. As a result, having the ability to quickly correctly estimate DF intake would allow identification at-risk groups development public programs aimed at improving their intake. In this study, authors translate cross-culturally adapt validated short food frequency questionnaire for assessment intake, thus adapting it Italian population. Methods: The...
Background: Vaccine effectiveness relies on various serological tests, whose aim is the measurement of antibody titer in serum samples collected during clinical trials before and after vaccination. Among assays required by regulatory authorities to grant influenza vaccine release there are: Hemagglutination inhibition (HAI), microneutralization (MN), Single Radial Hemolysis (SRH). Although antibodies are regarded be relatively stable, limited evidences effect multiple freeze–thaw cycles...
Cooking skills (CS) have the potential to improve self-care behaviours and healthy development among adolescents. The COVID-19 pandemic has affected lifestyles worldwide, present study aims investigate level of CS after pandemic, as well its associations with nutrition knowledge eating a cohort Italian We submitted an online survey about lifestyle changes students aged 13-21 years during pandemic. Based on overall culinary abilities, we divided respondents into high, medium low CS. Worsening...
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a novel term for Non-Alcoholic Fatty (NAFLD), is associated with liver mitochondrial dysfunction. We previously demonstrated that respiratory capacity in peripheral blood mononuclear cells (PBMCs) was significantly reduced patients MASLD compared to non-MASLD controls. For treatment, guidelines recommend behavioral and dietary changes reduce body weight. A recent 12-month clinical trial ameliorating patients’...
Seric IgM autoreactivity in 100 multiple sclerosis (MS) and 106 control (70 of whom had other neurological diseases) patients was assessed either by immunohistochemistry on normal human CNS tissue or to GD2, GD1a, GD3 ELISA thin layer chromatography (TLC) techniques. By double immunohistochemistry, we found that 44% the total MS population showed seric reactivity oligodendrocytes myelin, this finding being particularly frequent with secondary progressive MS. In non-MS cohort, positive...
Abstract The ability of resident cells to induce apoptosis invading immune is a major regulatory factor operating in immune‐privileged tissues, including the nervous system. We investigated cellular and molecular factors participating modulation response peripheral nerves, focusing on two cytotoxic pathways: fas ligand (fasL) perforin. fasL perforin expression was found by immunochemistry Schwann (Sc) nerve biopsies from patients with chronic inflammatory demyelinating polyneuritis human Sc...
Adolescence is a central phase for the development of person’s identity involving complex multidimensional changes and increasing vulnerability to distress. The aim this study was investigate psychological well-being adolescent students in Brescia (Northern Italy), two years after beginning Covid-19 pandemic. An online survey investigated extent reasons reported by high school their emotional distress (ED), also considering other factors such as physical activity, diet, sleep...