A5017198378- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Trypanosoma species research and implications
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Eosinophilic Disorders and Syndromes
- CAR-T cell therapy research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Macrophage Migration Inhibitory Factor
- Glycosylation and Glycoproteins Research
The Francis Crick Institute
2016-2023
University of Verona
2011-2014
CD4+ T cells develop distinct and often contrasting helper, regulatory, or cytotoxic activities. Typically a property of CD8+ cells, granzyme-mediated cell (CTL) potential is also exerted by cells. However, the conditions that induce CTLs are not entirely understood. Using single-cell transcriptional profiling, we uncover unique signature Granzyme B (GzmB)+ CTLs, which distinguishes them from other helper (Th) including Th1 strongly contrasts with follicular (Tfh) signature. The balance...
Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, interplay between effector immune cells and determines balance elimination or outgrowth. We discovered that protein TMEM123 over-expressed in tumour-infiltrating CD4 CD8 T lymphocytes it contributes to their phenotype. The presence infiltrating TMEM123+ CD8+ associated with better overall metastasis-free survival. localizes protrusions cells, lymphocyte migration cytoskeleton organization. silencing...
CD4+ T cell differentiation is influenced by a plethora of intrinsic and extrinsic factors, providing the immune system with ability to tailor its response according specific stimuli. Indeed, different classes pathogens may induce distinct balance programmes. Here, we report an uncommonly strong bias towards follicular helper (Tfh) cells reactive retroviral envelope glycoprotein model antigen, presented in natural context during infection. Conversely, same immunisation regimens, elicited...
Abstract Elucidation of the immune requirements for control or elimination retroviral infection remains an important aim. We studied induction adaptive immunity to neonatal with a murine retrovirus, under conditions leading immunological tolerance. found that absence either maternal offspring permitted efficient vertical transmission retrovirus. Maternal immunodeficiency allowed retrovirus induce central Th cell tolerance in infected offspring. In turn, this compromised offspring’s ability...
CD4 + T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity (CTLs) have been amply documented both in humans mice, particularly context human chronic infection cancer. Despite established description CTLs, well critical exert against MHC class II-expressing targets, their developmental memory maintenance requirements remain...
Chronic inflammation has been proposed as a possible driving force in Alzheimer's disease (AD) and better understanding of mechanisms may help to develop new approaches slow the progression this disorder. The present study focused on potential role vascular leukocyte trafficking 5XFAD mice, an experimental model AD recapitulating characteristics amyloid pathology. Thioflavin-S staining was used detect plaque deposition, whereas Nissl NeuN characterize neuropathological degeneration brain...
Abstract Cytotoxic CD8+ T cells are considered as one of the main populations effector immune in antitumor immunity. The absence central tumor area has become a major obstacle for solid immunotherapy. Thus, novel therapeutic strategies that could promote to accumulate urgently needed. To this aim, we want propose candidate INGM01 highly glycosylated mucin-like protein localized on cell surface and so far poorly characterized. High expression is reported be associated higher survival rate...