By a method using sealed envelopes series of patients with active chronic hepatitis who had not received corticosteroids or adrenocorticotrophic hormone was divided into two groups; one given prednisolone and the other used as control. Fifty-four were initially included in study over period 48 months, but five subsequently withdrawn when it became clear that diagnosis incorrect. The corticosteroid group then contained 22 control 27 patients. groups reasonably well matched; group, however,...

A congested " nutmeg" liver is a common post-mortem finding in patients dying from heart failure and the microscopic description dates Kiernan (1833).Similarly, it known that biochemical tests of function are abnormal circulatory (Jolliffe, 1930; Bernstein, Le Winn Simkins, 1942; Chaivez, Sepu'lveda Ortega, 1943).However, correlation functional changes with hepatic histology has not been attempted series any magnitude, evolution mild to severe requires elucidation.Aspiration biopsy various...

A long-term follow-up of at least 10 years or until death 44 patients taking part in a controlled prospective trial prednisolone therapy hepatitis B antigen negative chronic active (lupoid hepatitis) has been performed the Royal Free Hospital, London. Patients presenting between 1963 and 1967 were randomly allocated into control treatment groups. Ten year life table survival curves showed significantly improved group where 63% alive compared with only 27% (log rank test, P = 0.03). The...

This is a clinical study of 81 patients (32 male and 49 female), who are not alcoholics, with jaundice hepato-cellular type lasting longer than three months. Forty-nine these were under 21 years age. The natural history the condition response to corticosteroid therapy described; good symptomatic relief can be achieved corticosteroids but they do seem prolong life. aetiology discussed special reference relationship viral hepatitis, systemic lupus erythematosus, other disturbances immunity.

Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority patients with perhexiline have impaired ability to effect metabolic drug genetically determined. Information has not been available capacity in injury. Drug was measured using phenotyping procedure four injury 70 chronic disease serving as a control group. All damage showed substantial defect;...

SINCE Laënnec1 (1869) defined cirrhosis of the liver, it has become apparent that disease may occur in a variety clinical and pathological forms. Accepted etiologic factors contribute to hepatic hemochromatosis, Wilson's biliary or cardiac cirrhosis, but cause majority patients remains uncertain. A common association Western world is with alcoholism, although specific effect alcohol, malnutrition other its genesis not been established. Frequently, no accepted relation can account for...

RDIAisH 1289clouding of consciousness as they do on the presence an actual focal lesion in parietal area or elsewhere brain. SummaryIn later life, among reversible toxic and bio- chemical causes apt to provoke confusional symptoms, dehydration, alkalosis, anoxia, hypoglycaemia de- serve particular emphasis.Anoxia repeated hypo- glycaemia may lead ultimate dementia, although a rule only acute symptoms result.Cerebral tumour elderly be overlooked because simply resemble those growing old,...

LUPUS ERYTHEMATOSUS MEDITJOURNALPrevious work has shown that a gamma-globulin fraction is responsible for the L.E. cell phenomenon of Hargraves, part which involves alteration nuclear material white cells.This suggests factor an antibody nature, and present demonstration in tissue-cell nuclei fixed globulin derived from positive serum adds sup- port to this hypothesis.The also confirms recent finding _____________________________, Mellors et al.Pso.6.-Ntin-specsfic fluoreacence (1957), w h o...

The association of lichen planus and primary biliary cirrhosis in five patients is reported. coexistence the two diseases probably more than coincidental may be due to fact that both conditions are based on an alteration mechanisms. There great similarity between chronic graft-versus-host disease a common pathogenesis for entities has been postulated. Since one most manifestations disease, its with significance, although not unexpected.

In eight HBs and HBe antigen positive patients with chronic active liver disease, adenine arabinoside 59-monophosphate (ARA-AMP) given, intravenously or intramuscularly, six 12 hours, produced inhibition of viral replication. five given a short course therapy 10 15 mg/kg/day this effect was transient in two thrombocytopenia occurred. three further consecutive cases longer 5 after days the high dose, not seen replication for up to 13 months These lost HBV-DNA polymerase activity, serum DNA...

Over the past 5 years there has been an increase in number of reports patients with hepatic adenomas, and association found between these tumors use oral contraceptives. Up to January 1975 46 have reported this association. The histology varies, several names having applied variations. Adenoma or focal nodular hyperplasia seem be most appropriate terms. Most commonly used contraceptives involved. Usually contraceptive at least 2 years. In 1 case, adenoma was diagnosed 4 after stopping drug....

Twenty-six patients are described who had otherwise unexplained hepatitis after halothane anaesthesia. Twenty-four (92 per cent) multiple exposures, and 11 (42 died. In eight a characteristic pattern of delayed postoperative pyrexia has been found. Obesity was common, but the clinical features complications were those any severe hepatitis. Obesity, early onset jaundice anaesthesia, low thrombotest, associated with fatal outcome. None followed up recovery developed or biochemical evidence...