A5044109674- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Telomeres, Telomerase, and Senescence
- Polyamine Metabolism and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Testicular diseases and treatments
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Amino Acid Enzymes and Metabolism
- Renal Diseases and Glomerulopathies
- Protein Degradation and Inhibitors
- Bladder and Urothelial Cancer Treatments
- Otitis Media and Relapsing Polychondritis
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Acute Lymphoblastic Leukemia research
University Hospital of Zurich
2016-2025
University of Zurich
2012-2024
Swiss Group For Clinical Cancer Research
2024
University Cancer Center Hamburg
2007-2015
Universität Hamburg
2006-2015
University Medical Center Hamburg-Eppendorf
2006-2015
Eppendorf (Germany)
2005-2012
University of Glasgow
2012
Zero to Three
2012
Martini-Klinik
2008
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range functions, the polyamine spermidine needed hypusinate translation factor eukaryotic initiation 5A (eIF5A). We show here that hypusinated eIF5A (eIF5AH) promotes efficient expression subset mitochondrial proteins involved in TCA cycle and oxidative phosphorylation (OXPHOS). Several these have targeting sequences (MTSs) part confer increased dependency on eIF5AH. In macrophages,...
Abstract BACKGROUND Prostate specific membrane antigen (PSMA) is a suggested target for antibody‐based therapy of prostate cancer potentially involved in the regulation cell migration. This study was undertaken, to gain more insight on role PSMA early and its distribution various normal tissues. METHODS A total 1,700 different cancers treated by radical prostatectomy 612 samples from 76 tissue types were successfully analyzed immunohistochemistry (IHC) microarray (TMA) format. immunostaining...
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but biological implications this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing ability CD4
We investigate the in vivo patterns of stem cell divisions human hematopoietic system throughout life. In particular, we analyze shape telomere length distributions underlying behavior within individuals. Our mathematical model shows that these contain a fingerprint progressive loss and fraction symmetric proliferations. predictions are tested against measured humans across all ages, collected from lymphocyte granulocyte sorted data 356 healthy individuals, including 47 cord blood 28 bone...
Abstract Background We have previously reported significant downregulation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in prostate cancer (PCa) compared to the surrounding benign tissue. UCHL1 plays an important role system and different cellular processes such as cell proliferation differentiation. now show that underlying mechanism PCa is linked its promoter hypermethylation. Furthermore, we present evidences expression can affect behavior cells ways. Results Methylation specific...
Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) lines, hormone-sensitive castration-resistant prostate carcinoma lines different bladder lines. In contrast, non-malignant cells were significantly less sensitive. MonA highly synergistic with cisplatin GCT cells. Induction of autophagy at lower lysosomal...
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), outcome patients remains poor due to development drug resistance. Thus, new drugs are urgently needed. We investigated efficacy, toxicity and mechanism action marine triterpene glycoside frondoside A (FrA) using CRPC cell lines vitro vivo. FrA revealed high efficacy human cells, while non-malignant cells were less sensitive. Remarkably, proliferation colony formation resistant enzalutamide...
Prostate cancer (PCa) is the most common type of found in men and among leading causes death western world. In present study, we compared individual protein expression patterns from histologically characterized PCa surrounding benign tissue obtained by manual micro dissection using highly sensitive two-dimensional differential gel electrophoresis (2D-DIGE) coupled with mass spectrometry. Proteomic data revealed 118 spots to be differentially expressed (n = 24) 21) prostate tissue. These were...
Chronic lymphocytic leukemia (CLL) is the most common in Western world. Survival of CLL cells depends on their close contact with stromal lymphatic tissues, bone marrow and blood. This microenvironmental regulation cell survival involves secretion chemo- cytokines as well expression adhesion molecules. Since may also be driven by antigenic stimulation through B-cell antigen receptor (BCR), we explored hypothesis that these processes linked to each other. We tested if could serve an reservoir...
Glioblastomas are highly aggressive brain tumors of adults with poor clinical outcome. Despite a broad range new and more specific treatment strategies, therapy glioblastomas remains challenging relapse in all cases. Recent work demonstrated that the posttranslational hypusine modification eukaryotic initiation factor 5A (eIF-5A) is crucial regulator cell proliferation, differentiation an important tumor formation, progression maintenance. Here we report eIF-5A as well hypusine-forming...
The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently, cellular proliferation through an unknown mechanism. Using a novel conditional knockout mouse model Caenorhabditis elegans model, we found evolutionarily conserved role for the DOHH-mediated second step...
Patients with advanced stages of hepatocellular carcinoma (HCC) face a poor prognosis. Although encouraging clinical results have been obtained multikinase inhibitor sorafenib, the development improved therapeutic strategies for HCC remains an urgent goal. Aurora kinases are key regulators cell cycle, and their uncontrolled expression promotes aneuploidy tumor development. In tissue microarray analyses, we detected aurora-A kinase in all examined 93 human samples, whereas aurora-B levels...
The present study aimed to investigate the proteome profiling of surgically treated prostate cancers. Hereto, 2D-DIGE and mass spectrometry were performed for protein identification, data validation peroxiredoxin 3 4 (PRDX3 PRDX4) was accomplished by reverse phase arrays (RPPA). Formal Concept Analysis (FCA) method applied assess whether TMPRSS2-ERG gene fusion could influence degree overexpression PRDX3 PRDX4 in cancer. Lastly, we an vitro functional characterization both using classical...