A5080047782- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Optical Imaging and Spectroscopy Techniques
- Head and Neck Anomalies
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Dental Anxiety and Anesthesia Techniques
- Airway Management and Intubation Techniques
- Child Abuse and Related Trauma
- Ophthalmology and Eye Disorders
- Otolaryngology and Infectious Diseases
- Social and Educational Sciences
- Trigeminal Neuralgia and Treatments
- Anesthesia and Sedative Agents
- Tracheal and airway disorders
- Injury Epidemiology and Prevention
- Anesthesia and Neurotoxicity Research
- Nasal Surgery and Airway Studies
- Facial Nerve Paralysis Treatment and Research
- Neonatal and fetal brain pathology
- Eicosanoids and Hypertension Pharmacology
- S100 Proteins and Annexins
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
Aarhus University Hospital
2013-2025
Aalborg University
2023
Regional Hospital Horsens
2020-2023
Aarhus University
2016-2023
Society for Neuroscience
2020-2021
Society for Neuroscience in Anesthesiology and Critical Care
2020-2021
Committee on Publication Ethics
2021
Charité - Universitätsmedizin Berlin
2020
Odense University Hospital
2007
Hospital South West Jutland
2005
Introduction Vasopressor support is often preferred as an efficient and convenient way to raise the blood pressure during surgery intensive care therapy. However, optimal vasopressor for ensuring organ flow tissue oxygen delivery remains undetermined. This study aims assess impact of norepinephrine versus phenylephrine on cerebral non-cerebral perfusion oxygenation anaesthesia in neurosurgical patients with brain tumours. The also explores agents distribution cardiac output between various...
Studies in anesthetized patients suggest that phenylephrine reduces regional cerebral oxygen saturation compared with ephedrine. The present study aimed to quantify the effects of and ephedrine on blood flow metabolic rate brain tumor patients. authors hypothesized selected regions ephedrine.In this double-blinded, randomized clinical trial, 24 tumors were randomly assigned or treatment. Positron emission tomography measurements peritumoral normal contralateral performed before during...
This study compared ephedrine versus phenylephrine treatment on cerebral macro- and microcirculation, measured by blood flow, capillary transit time heterogeneity, in anesthetized brain tumor patients. The hypothesis was that heterogeneity selected regions is greater during than ephedrine, thus reducing oxygen tension.In this single-center, double-blinded, randomized clinical trial, 24 patients were randomly assigned to or phenylephrine. Magnetic resonance imaging of peritumoral...
Background: The speculation that cerebral tissue oxygen saturation (SctO 2 ) measured using near-infrared spectroscopy reflects the balance between metabolic rate of and delivery has not been validated. Our objective was to correlate SctO with extraction fraction (OEF) positron emission tomography; OEF is ratio these variables. Materials Methods: This cohort study based on data collected in a previously published trial assessing phenylephrine versus ephedrine treatment anesthetized patients...
Introduction During brain tumour surgery, vasopressor drugs are commonly administered to increase mean arterial blood pressure with the aim of maintaining sufficient cerebral perfusion pressure. Studies used vasopressors show that oxygen saturation is reduced after phenylephrine administration, but unaltered by ephedrine administration. These findings may be explained different effects and on microcirculation, in particular capillary transit-time heterogeneity, which determines extraction...
Objective: This is a secondary analysis of data from previous study anesthetized brain tumor patients receiving ephedrine or phenylephrine infusions. 18 with magnetic imaging verified contrast enhancement were included. We hypothesized that vasopressors induce microcirculatory flow changes, characterized by increased capillary transit time heterogeneity (CTH) and decreased mean (MTT), in regions exhibiting BBB leakage. Methods: Postvasopressor to prevasopressor ratios CTH, MTT, relative...
Background The optimal blood pressure management strategy in patients undergoing endovascular therapy for acute ischemic stroke is unknown. This pilot study aimed to assess the feasibility of a standard versus individualized during therapy. Methods randomized controlled trial included adult with large‐vessel occlusion anterior circulation Patients were either (mean arterial [MABP] targeted between 70 and 90 mm Hg) or (MABP ±10% baseline value measured neurointerventional suite) targets until...