A5100405817- Catalytic C–H Functionalization Methods
- Carbohydrate Chemistry and Synthesis
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Glycosylation and Glycoproteins Research
- Sulfur-Based Synthesis Techniques
- Organoboron and organosilicon chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Oxidative Organic Chemistry Reactions
- Surfactants and Colloidal Systems
- Polyamine Metabolism and Applications
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Supramolecular Chemistry and Complexes
- Fluorine in Organic Chemistry
- Chemical synthesis and alkaloids
- Chemical Synthesis and Reactions
- Seaweed-derived Bioactive Compounds
University of Macau
2023
City University of Macau
2023
The First People's Hospital of Tianmen
2021-2023
Henan Normal University
2020-2022
Hainan University
2022
State Ethnic Affairs Commission
2021-2022
Guizhou Normal University
2022
National Institutes for Food and Drug Control
2022
Calgary Laboratory Services
2021
University of Calgary
2011-2021
The Pd-catalyzed cross-coupling of racemic tertiary allylic carbonates and allylboronates is described. This reaction generates all-carbon quaternary centers in a highly regioselective enantioselective fashion. outcome these reactions consistent with process that proceeds by way 3,3′-reductive elimination bis(η1-allyl)palladium intermediates. Strategies for distinguishing the product alkenes application to synthesis (+)-α-cuparenone are also
Two highly efficient and convenient methods for the synthesis of functionalized substituted allylic boronates are described. In one procedure, readily available acetates converted to catalyzed by Ni/PCy3 or Ni/PPh3 complexes with high levels stereoselectivity in good yields. Alternatively, borylation can be accomplished commercially Pd catalysts [e.g., Pd2(dba)3, PdCl2, Pd/C], starting easily accessed halides.
A ligand-promoted RhIII -catalyzed C(sp2 )-H activation/thiolation of benzamides has been developed. Using bidentate mono-N-protected amino acid ligands led to the first example aryl thiolation reactions directed by weakly coordinating directing amide groups. The reaction tolerates a broad range amides and disulfide reagents.
The nickel-catalyzed enantioselective addition of allylboronic acid pinacol ester [allylB(pin)] to α,β,γ,δ-unsaturated aldehydes is described. This reaction results in a remarkable inversion substrate olefin geometry, providing the Z,E-configured product good enantioselectivity and stereoselectivity. appears proceed by conversion dienal an unsaturated π-allyl complex followed reductive elimination via transition state II. Enantioselectivities range from 73−94% ee for δ-substituted dienals...
ABSTRACT Dysregulated transforming growth factor beta (TGF-β) signaling is associated with a spectrum of osseous defects as seen in Loeys-Dietz syndrome, Marfan and Camurati-Engelmann disease. Intriguingly, neurofibromatosis type 1 (NF1) patients exhibit many these characteristic skeletal features, including kyphoscoliosis, osteoporosis, tibial dysplasia, pseudarthrosis; however, the molecular mechanisms mediating phenotypes remain unclear. Here, we provide genetic pharmacologic evidence...
A series of 4-arylsulfonylimino-4,5-dihydrofurans (14 examples) were efficiently synthesized in good to excellent yields by using the copper-catalyzed three-component reaction between sulfonyl azides, phenylacetylene, and β-ketoesters tetrahydrofuran (THF) at 40 °C for 8 h presence triethylamine (TEA). plausible mechanism this process is proposed.
A method for convenient synthesis of<italic>N</italic>-alkyl-2-aryl-indole-3-carbaldehyde<italic>via</italic>carbene C–H bond insertion.
A general method for selective ortho C-H arylation of ketone, with boron reagent enabled by rhodium complexes excellent yields, is developed. The transformation characterized the use air-stable Rh catalyst, high monoarylation selectivity, and yields most substrates.
Colorectal cancer (CRC) is a life‑threatening malignant tumor of the digestive tract. Diverse gene mutations and complicated alterations to signaling pathways in CRC lead heterogeneity response chemotherapy. Moreover, anticancer drugs for chemotherapy are limited due adverse events. Therefore, developing more effective, tolerable safe treatment important. The present study aimed investigate effect lycorine on human cell proliferation, migration, invasion, apoptosis, cycle distribution, as...
Well-defined glycopolymers fabricated by microwave-accelerated emulsion polymerization offer promising prospects for deciphering glycan-dependent interactions.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThermodynamic and Conformational Implications of Glycosidic Rotamers Preorganized for BindingDavid R. Bundle, Ramón Alibés, Shah Nilar, Albin Otter, Michael Warwas, Ping ZhangView Author Information Department Chemistry, University Alberta Edmonton, T6G 2G2, Canada Cite this: J. Am. Chem. Soc. 1998, 120, 21, 5317–5318Publication Date (Web):May 15, 1998Publication History Received22 December 1997Published online15 May 1998Published inissue 1...
(S)-2,15-Cl2-DHTP–boron complex catalyst for the asymmetric Diels–Alder cycloaddition of 2′-hydroxychalcones and dienes was developed tested. The resulting cyclohexenes with three chiral centers were obtained in high yields (up to 98%) excellent stereoselectivities >20:1 endo/exo, >99% ee). This catalytic system features efficiency, broad substrate scopes, mild reaction conditions. In addition, a DFT study performed explain stereochemical course induction.
An efficient ( S )-2,15-Cl 2 -DHTP-catalyzed enantioselective conjugate addition of organic boronic acids to β-enaminones has been developed.
Although there are many therapeutic strategies such as surgery and chemotherapy, the prognosis of osteosarcoma (OS) is still far from being satisfactory. It urgent to develop more effective, tolerable safe drugs for treatment OS. In present study, we investigated anti-OS activity Alantolactone (ALT), a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium, probed possible mechanism involved. We demonstrated that ALT significantly inhibited cell proliferation various human...
Background: Osteosarcoma is the most common primary malignant bone neoplasm and associated with abysmal prognosis. There are limitations of current treatment methods. Therefore, developing new agents to treat osteosarcoma exceptionally urgent. Aim: This study aimed evaluate anticancer effects evodiamine (EVO) on cells and, meanwhile, investigate underlying mechanisms involved. Materials Methods: The effect EVO proliferation was detected by MTT assay, crystal violet assay colony formation...
An efficient asymmetric double-conjugate addition of organic boronic acids to dienones catalyzed by chiral 3,3′-disubstituted-BINOLs or hydroxytetraphenylenes has been developed.
Because of the large dimension trityl group and truncated conical geometry cyclodextrin (CD) molecules, it is unclear if there enough space at narrower end CDs to permit a per-6-O-tritylation. This work demonstrates that indeed possible simultaneously install O6-position every glucopyranosyl unit in CD. A novel per-6-substitution method has been developed for CD chemistry.
Herein, we report the enantioselective conjugate addition of organic boronic acids to α,β-unsaturated 2-acyl imidazoles using (R)-3,3′-I2-BINOL as catalyst. The catalytic system shows high efficiency and tolerance alkenylboronic heteroarylboronic acids. corresponding Michael products were obtained in moderate excellent yields with enantioselectivities (up 97% ee). A gram-scale reaction was also conducted, desired product yield no erosion enantioselectivity. Finally, synthetic utility...
An efficient method for the Lewis acid promotion of synthesis 9-phosphoryl fluorenes has been reported. This focuses on ketone phosphonylation to form a C-P bond and C-C between diphenylmethanone H-phosphinate esters, H-phosphites, H-phosphine oxides via phospha-aldol elimination, in which series fluorene derivatives were selectively obtained moderate excellent yields.