A5101633377- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Angiogenesis and VEGF in Cancer
- Advanced Memory and Neural Computing
- Algal biology and biofuel production
- Cancer, Hypoxia, and Metabolism
- Conducting polymers and applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Coastal and Marine Dynamics
- Photoreceptor and optogenetics research
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Lymphatic System and Diseases
- Ocean Waves and Remote Sensing
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Electromagnetic Compatibility and Noise Suppression
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Marine and coastal ecosystems
- Wave and Wind Energy Systems
- Cancer Genomics and Diagnostics
- Neuroscience and Neural Engineering
- Seaweed-derived Bioactive Compounds
- Proteoglycans and glycosaminoglycans research
Nanyang Technological University
2018-2024
Peking University
2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2019-2024
University of Notre Dame
2020-2024
Peking University First Hospital
2024
CAS Key Laboratory of Urban Pollutant Conversion
2024
University of Science and Technology Beijing
2024
University of Electronic Science and Technology of China
2024
Michigan State University
2024
Lysophosphatidic acid (LPA) has diverse biological activities implicated in tumor progression, including increasing cell migration, invasion and metastasis. However, the underlying mechanisms for LPA-induced human hepatocellular carcinoma (HCC) migration are poorly understood.We sought to determine promoting effect of LPA on HCC adhesion by transwell matrix assays, respectively. Levels metalloproteinase, MMP-2 MMP- 9 from cells were assayed ELISA p38 mitogenactivated protein kinase (MAPK)...
History-dependent memristive behaviors, which can emulate the plasticity, short-term memory to long-term transition, and learning function of biological synapses, are demonstrated in viologen/triphenylamine-containing polymer organic redox system. Together with advantages mechanical flexibility deformability, resistive switching materials devices promising candidates for construction large-scale neuromorphic networks smart computers. As a service our authors readers, this journal provides...
Abstract Polymer memristors with light weight and mechanical flexibility are preeminent candidates for low-power edge computing paradigms. However, the structural inhomogeneity of most polymers usually leads to random resistive switching characteristics, which lowers production yield reliability nanoscale devices. In this contribution, we report that by adopting two-dimensional conjugation strategy, a record high 90% polymer has been achieved miniaturization low power potentials. By...
Abstract Facing the exponential growth of data digital communications and advent artificial intelligence, there is an urgent need for information technologies with huge storage capacity efficient computing processing. However, traditional von Neumann architecture silicon‐based technology will reach their limits cannot meet requirements ultrasmall size, ultrahigh density, memory computing. Considering these issues, organic material resistance switching memristor devices have become promising...
Aiming at the problems of low energy utilization and environmental pollution in China's livestock poultry breeding industry under carbon peaking neutralization goals, this paper proposes an optimal scheduling model for multi-energy coupling integrated system with ladder-type trading mechanism demand response. First, based on construction a reward punishment mechanism, explores potential interaction between ability multiple heterogeneous sources emissions consideration impact capture...
Hypoxia-inducible factor 1 (HIF-1), a heterodimer comprising the oxygen-regulated subunit, HIF-1alpha, and HIF-1beta, mediates transcription of gene for vascular endothelial growth (VEGF). Overexpression HIF-1alpha is associated with tumor angiogenesis cell proliferation invasion. We examined effects inhibiting activity on human gastric cancer in vivo.Human TMK-1 cells were stably transfected pHIF-1alphaDN, an expression plasmid encoding dominant-negative form that dimerizes endogenous...
Abstract Memristors with enormous storage capacity and superior processing efficiency are of critical importance to overcome the Moore’s Law limitation von Neumann bottleneck problems in big data artificial intelligence era. In particular, integration multifunctionalities into a single memristor promises an essential strategy obtaining high-performance electronic device that satisfies nowadays increasing demands processing. this contribution, we report proof-of-concept polymer memristive...
Vascular endothelial growth factor (VEGF) is the predominant pro-angiogenic cytokine in human malignancy, and its expression correlates with disease recurrence poor outcomes patients colorectal cancer. Recently, of vascular receptors (VEGFRs) has been observed on tumours epithelial origin, including those arising colon, but molecular mechanisms governing potential VEGF-driven biologic functioning these are not well characterised. In this report, we investigated role Src family kinases (SFKs)...
Bevacizumab (Bev), a monoclonal antibody to vascular endothelial growth factor (VEGF), is used in combination with chemotherapy for the treatment of metastatic colorectal cancer (CRC). The effects Bev on angiogenesis have been well described, but direct effect tumour cells unknown. This study was carried out determine molecular and phenotypic changes CRC after chronic exposure vitro. Human cell lines were chronically exposed (3 months) vitro develop Bev-adapted (Bev-A) lines. Vascular family...
The comprehensive metabolomic analyses using eukaryotic and prokaryotic cells are an effective way to identify biomarkers or biochemical pathways which can then be used characterize disease states, differences between cell lines inducers of cellular stress responses. One the most commonly extraction methods for metabolomics is Bligh Dyer method (BD) separates metabolome into polar nonpolar fractions. These fractions typically analysed separately hydrophilic interaction liquid chromatography...
The epidermal growth factor receptor (EGF-R) pathway plays a pivotal role in the progression of human gastric cancer. angiogenic vascular endothelial (VEGF) has been shown to be induced by EGF various cancer cell lines. Neuropilin-1 (NRP-1) acts as coreceptor for VEGF-165 and increases its affinity VEGF 2 (VEGFR-2) cells. Furthermore, NRP-1 found expressed tumour cells enhance angiogenesis preclinical models. We examined expression mRNA EGF-R protein seven was five lines, closely mirrored...
Neuropilin-1 (NRP-1) is a novel co-receptor for vascular endothelial growth factor (VEGF). expressed in pancreatic cancer, but not nonmalignant tissue. We hypothesised that NRP-1 expression by cancer cells contributes to the malignant phenotype. To determine role of was stably transfected into human cell line FG. Signal transduction assessed Western blot analysis. Susceptibility anoikis (detachment induced apoptosis) evaluated colony formation after suspension. Chemosensitivity gemcitabine...
The objective of present study was to offer insights into the metabolic responses hepatocellular carcinoma (HCC) surgical resection and signatures latent in early HCC recurrence (one year after operation). Urinary profiling employing gas chromatography time-of-flight mass spectrometry (GC-TOF MS) utilized investigate complex physiopathologic regulations operational intervention. It revealed that an intricate series including energy metabolism, amino acid nucleoside tricarboxylic (TCA) cycle,...
The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native (FCS), which extracted and isolated sea cucumber Cucumaria frondosa, the anti-cancer mechanism of LFCS on mouse Lewis lung carcinoma (LLC) investigated. results showed that remarkably inhibited LLC growth metastasis in a dose-dependent manner. induced cell cycle arrest by increasing p53/p21 expression apoptosis through activation caspase-3 activity cells. Meanwhile, suppressed vascular endothelial factor...
Conductance of the viologen/terpyridyl-iron polymer bilayer structure has been effectively modulated by an electrochemical redox reaction for synaptic emulation.