A5051907554- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Catalysis for Biomass Conversion
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Lignin and Wood Chemistry
- Catalysis and Hydrodesulfurization Studies
- Electrohydrodynamics and Fluid Dynamics
- Thermochemical Biomass Conversion Processes
- Receptor Mechanisms and Signaling
- Ultrasound and Cavitation Phenomena
- Electrospun Nanofibers in Biomedical Applications
- Catalytic Processes in Materials Science
- Magnetic and Electromagnetic Effects
- Retinal Development and Disorders
- Advanced Photocatalysis Techniques
- Nanocluster Synthesis and Applications
- Photoreceptor and optogenetics research
- HIV/AIDS drug development and treatment
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
Southwest Hospital
2020-2025
Army Medical University
2020-2025
Dalian Medical University
2015-2024
Chongqing Medical University
2015-2024
Second Affiliated Hospital of Chongqing Medical University
2015-2024
Hong Kong University of Science and Technology
2024
Hong Kong Polytechnic University
2019-2024
First Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Singapore Clinical Research Institute
2019-2024
Tumor hypoxia is one of the major challenges for treatment tumors, as it may negatively affect efficacy various anticancer modalities. In this study, a tumor-targeted redox-responsive composite biocatalyst designed and fabricated, which combine tumor starvation therapy low-temperature photothermal oxygen-deprived tumors. The nanosystem was prepared by loading porous hollow Prussian Blue nanoparticles (PHPBNs) with glucose oxidase (GOx) then coating their surface hyaluronic acid (HA) via...
Background: As one of the most effective triggers with high tissue-penetrating capability and non-invasive feature, ultrasound shows great potential for controlling drug release enhancing chemotherapeutic efficacy. In this study, we report, first time, construction a phase-changeable drug-delivery nanosystem programmable low-intensity focused (LIFU) that could trigger drug-release significantly enhance anticancer delivery. Methods: Liquid-gas perfluorocarbon (perfluoropentane) an...
No prominent advancements in osteosarcoma (OS) treatment have been made the past 20 years. Although photodynamic therapy (PDT) is an emerging technique for cancer therapy, lack of targeted photosensitizers OS severely limits its applications. In this study, we constructed a potential theranostic nanoplatform by using (poly (lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) encapsulating IR780 into shell (PLGA-IR780 NPs), which were further camouflaged with human cell membranes from HOS...
Facile fabrication of multimodal imaging probes is highly desired for bioimaging application due to their integrated advantages several modalities. Here, we report a simple and one-step mild strategy fabricate multifunctional Gd2O3/Au hybrid nanoprobe. Bovine serum albumin (BSA) was used as the template in biomineralization synthesis. The fabricated BSA-Gd2O3/Au nanoprobe showed excellent chemical stability, intense near-infrared (NIR) fluorescence, good magnetic resonance (MRI) ability....
There has been a growing interest in advanced technology that transforms biomass-derived feedstock into renewable chemicals. Hydrothermal liquefaction (HTL) of lignin low-molecular-weight fragments (e.g., monomer, dimer, and oligomer), subsequent catalyzed transformations, offer the promise unlocking diverse aromatic products. In consideration diversity feedstocks, we shed light on impact variations structure conversion efficiency. This review aims to present latest advances HTL highlights...
Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options drug delivery with their tunable loading release To take advantage of the features carrier polymers, we present one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained PVA core silk shell after system...
Disulfiram (DSF), a U.S. Food and Drug Administration (FDA)-approved drug for the treatment of chronic alcoholism, is also used as an antitumor in combination with Cu2+ ions. However, studies have shown that endogenous dose tumor tissues still insufficient to form relatively high levels bis(N,N-diethyldithiocarbamate) copper(II) complex (denoted Cu(DTC)2) selectively eradicate cancer cells. Here, DSF-loaded hollow copper sulfide nanoparticles (DSF@PEG-HCuSNPs) were designed achieve...
Glucose isomerization to fructose is one of the most important reactions in field biomass valorization. We demonstrate wood waste valorization with MgCl2 salt synthesize an environment-friendly catalyst (i.e., MgO-biochar), which exhibits effective glucose-to-fructose over 30% yield and 80% selectivity at only 100 °C for 30 min water as a green medium. This study highlights that one-step synthesis can effectively disperse tether MgO nanostructures biochar matrix, displays significant...
Mono-therapeutic modality has limitations in combating metastatic lesions with complications. Although emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading to ineffective antitumor immune responses and immunotherapeutic resistance. The rational combination of several therapeutic modalities may potentially become a new strategy effectively combat cancer.Poly lactic-co-glycolic acid (PLGA, 50 mg) nanospheres were constructed photothermal...
Pathological angiogenesis is a crucial factor that causes atherosclerotic plaque rupture. Sinoporphyrin sodium-mediated sonodynamic therapy (DVDMS-SDT) induces regression of neovascularization in humans without causing obvious side effects. However, clinical noninvasive theranostic strategy for urgently needed. A nanoplatform designed multimodality imaging-guided SDT theranostics, termed PFP-HMME@PLGA/MnFe2 O4 -ramucirumab nanoparticles (PHPMR NPs), fabricated. It encapsulates manganese...
Abstract Copper/carbon catalysts under different electron‐transfer regimes can evolve both radical and nonradical pathways in peroxide activation. However, the underlying trigger to manipulate transition between is unclear. Herein, it revealed that Cu species a state of sub‐nanometre particles (SNPs, < 1 nm) exhibits an electrophilic nature, which opposite its nucleophilic nature at larger scale (nanoclusters, > nm). This switch nucleophile/electrophile leads distinct catalytic...
Abstract Disturbance of spatiotemporal oxygen balance is the main cause delayed healing or nonhealing large bone defects. The accurate administration to regulate disruptions in equilibrium during 9 h hypoxia imperative for tissue regeneration. Herein, oxygen‐loaded nanobubbles prepared by double emulsification are successfully embedded GelMA/HepMA microsphere macromolecular meshwork microfluidic techniques, and a spatiotemporalized hydrogel constructed noncovalently binding morphogenetic...
A multifunctional drug delivery vehicle, which combines the active targeted mesoporous silica nanoparticle (MSN) and microbubble (MB) system, is proposed fabricated. The resulting vehicle integrates merits of high loading capacity, multitargeting, ultrasound‐guided releasing. Folate (FA), serves as an ligand, modified to surface MSN (MSN‐FA) enhance cell membrane translocation. MSN‐FA loaded with tanshinone IIA (TAN), then encapsulated in a (denoted MSN‐FA‐TAN‐MB) for more precise tumor...
Valorization of lignin to valuable chemicals and biofuels increases the economic viability sustainable biorefineries.
In spite of widespread applications nano-photosensitizers, poor tumor penetration and severe hypoxia in the microenvironment (TME) always result an undesirable therapeutic outcome photodynamic therapy (PDT). Herein, a biocompatible agarose-based hydrogel incorporated with sodium humate (SH), manganese oxide (MnO2) chlorin e6 (Ce6) was synthesized as agarose@SH/MnO2/Ce6 through "co-trapped" strategy during sol-gel process employed for combined photothermal (PTT) enhanced PDT. NIR-induced...