A5073676387- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Aluminum toxicity and tolerance in plants and animals
- Acute Kidney Injury Research
- Radioactive element chemistry and processing
- Neonatal Respiratory Health Research
- Seed Germination and Physiology
- Radiation Dose and Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gold and Silver Nanoparticles Synthesis and Applications
- Heavy Metal Exposure and Toxicity
- Respiratory Support and Mechanisms
- Extracellular vesicles in disease
- Radio Wave Propagation Studies
- Advanced Photonic Communication Systems
- Railway Systems and Energy Efficiency
- Light effects on plants
- Plant Genetic and Mutation Studies
- Biosensors and Analytical Detection
Army Medical University
2024-2025
Beijing Jiaotong University
2024
Affiliated Hospital of North Sichuan Medical College
2021
State Key Laboratory of Silkworm Genomic Biology
2020-2021
Southwest University
2020-2021
Anhui Agricultural University
2014-2020
Chinese Academy of Sciences
2015-2017
Beijing Institute of Nanoenergy and Nanosystems
2017
Technical Institute of Physics and Chemistry
2015-2016
Chengdu University of Technology
2016
A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer development through complex cellular signaling networks, it is thus challenging to completely eradicate tumors via monotherapy. Here, PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities, serving as bioreactors responsive TME cues, were synthesized typical solvothermal method for augmented sonodynamic therapy (SDT) chemodynamic (CDT) elicitation of robust immune response. The CFP occupying...
Carbon‐based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, high efficiency theranostics. In this work, an alternative nanoplatform based on carbon–silica nanocapsules gold nanoparticle in the cavity (Au@CSN) The encapsulated chemodrug doxorubicin can be released from Au@CSN mesoporous hollow structure near‐infrared light pH...
Biocompatibility and bioelimination are basic requirements for systematically administered nanomaterials biomedical purposes. Gold-based plasmonic have shown potential applications in photothermal cancer therapy. However, their inability to biodegrade has impeded practical application. In this study, a kind of bioeliminable magnetoplasmonic nanoassembly (MPNA), assembled from an Fe3O4 nanocluster gold nanoshell, was elaborately designed computed tomography, photoacoustic magnetic resonance...
Unavoidable damage to normal tissues and tumor microenvironment (TME) resistance make it challenging eradicate breast carcinoma through radiotherapy. Therefore, is urgent develop radiotherapy sensitizers that can effectively reduce radiation doses reverse the suppressive TME. Here, a novel biomimetic PEGylated Cu
Background: Reactive oxygen species (ROS), as a category of highly reactive molecules, are attractive for eliminating tumor cells in situ.However, the intrinsic microenvironment (TME) always compromises treatment efficacy.In another aspect, silk fibroin (SF), natural biomacromolecules, is promising synthesis metallic nanocrystals via biomineralization.Methods: As proof-of-concept study, AuPt bimetallic nanozyme derived from bioinspired crystallization chloroauric acid and chloroplatinic was...
Background: Nanoradiosensitizers containing high Z-group elements have been reported widely as potential candidates for radiotherapy. However, the specific regulatory mechanism is unclear, and biodegradability needs to be addressed urgently. Methods: We synthesized a silk sericin-containing nano assembly, Pt@Bi2Se3-RGD (PBR). PBR's antitumor bioeliminable effects were demonstrated in 4T1 tumor cells vitro vivo. The immuno-radiotherapy of PBR evaluated using bilateral model. Results:...
With the aim of fabricating multifunctional nanoplatforms for cancer diagnosis and therapy, we design hollow ZrO2 nanospheres as novel nanocarriers with enhanced CT imaging properties to integrate NIR light absorbing agents anti-cancer drugs into one nanosystem. Polypyrrole (PPy) is encapsulated endow nanosystem strong photothermal transfer capability via an oxidative polymerization method. The drug, doxorubicin (DOX), was loaded a high loading content Dox could be released from carrier by...
Abstract Depleted uranium (DU), when accidentally released from the nuclear industry, can enter human body and cause kidney damage, as DU induces oxidative damage apoptosis through mitochondrial pathways inflammatory reactions. The existing nanoparticles used to treat injury have low bioavailability poor targeting. In this study, mesoporous polydopamine (MPDA), poly‐(ethylene glycol) (PEG), triphenylphosphonium (TPP) are combined develop a novel mitochondrion‐targeting bifunctional...
Alpha (a)-particle radiation has been thoroughly studied in the occupational and residential environments, but biological mechanisms induced by a-particle on plants are not clearly understood.In this study, effects were examined using different total doses (1, 10, 100 Gy, respectively) of 241 Am, Arabidopsis embryos.No significant difference germination percentage was observed between 3 levels control.Germination speed root length increased treatment with 1-Gy dose a-particles, decreased...
On page 4252, L. Li, H. Y. Liu, and co-workers demonstrate a multi-functional nanoplatform for cancer theranostics, based on carbon–silica nanoparticles with gold nanoparticle core. Doxorubicin can be encapsulated released in controlled manner using pH near-infrared light stimuli, leading to spatiotemporal targeting reduce off-target toxicity.