A5082684197- Advanced Materials and Mechanics
- Carbon Nanotubes in Composites
- Graphene research and applications
- Cellular and Composite Structures
- Advanced Sensor and Energy Harvesting Materials
- Mechanical Behavior of Composites
- Structural Analysis and Optimization
- Metabolism, Diabetes, and Cancer
- Photoacoustic and Ultrasonic Imaging
- Modular Robots and Swarm Intelligence
- Nanoplatforms for cancer theranostics
- Advanced ceramic materials synthesis
- Automotive and Human Injury Biomechanics
- Composite Material Mechanics
- Force Microscopy Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Maritime Navigation and Safety
- Structural Response to Dynamic Loads
- Fiber-reinforced polymer composites
- Crystallization and Solubility Studies
- Polydiacetylene-based materials and applications
- Hormonal Regulation and Hypertension
- Aluminum Alloys Composites Properties
- Fatigue and fracture mechanics
- High-Velocity Impact and Material Behavior
Beihang University
2016-2025
Tsinghua University
1999-2025
Jinan University
2016-2025
Southern University of Science and Technology
2025
Dalian Maritime University
2025
Beijing University of Posts and Telecommunications
2025
Switch
2025
Wenzhou Medical University
2024
Shaanxi Normal University
2018-2024
Shanghai University
1993-2024
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism action. Its glucose-lowering effect results from decreased hepatic glucose production and increased utilization. Metformin’s beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) major regulator lipid metabolism. Here we report that metformin activates AMPK in hepatocytes; as result, acetyl-CoA carboxylase (ACC) activity reduced,...
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism action. Its glucose-lowering effect results from decreased hepatic glucose production and increased utilization. Metformin’s beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) major regulator lipid metabolism. Here we report that metformin activates AMPK in hepatocytes; as result, acetyl-CoA carboxylase (ACC) activity reduced,...
Metamaterials have unprecedented properties that facilitate the development of advanced devices and machines. However, their interconnected building structures limit applications, especially in fields require large deformation, rich programmability efficient shape-reconfigurability. To break this exploit more potentialities metamaterials, an innovative material design strategy is proposed, named mechanical pixel (MP) array design. Similar to a screen displays images by adjusting colors...
Background: As one of the most effective triggers with high tissue-penetrating capability and non-invasive feature, ultrasound shows great potential for controlling drug release enhancing chemotherapeutic efficacy. In this study, we report, first time, construction a phase-changeable drug-delivery nanosystem programmable low-intensity focused (LIFU) that could trigger drug-release significantly enhance anticancer delivery. Methods: Liquid-gas perfluorocarbon (perfluoropentane) an...
Drug-resistant bacterial infections pose a serious threat to human health; thus, there is an increasingly growing demand for nonantibiotic strategies overcome drug resistance in infections. Mild photothermal therapy (PTT), as attractive antibacterial strategy, shows great potential application due its good biocompatibility and ability circumvent resistance. However, efficiency limited by the heat of bacteria. Herein, Cu2O@MoS2, nanocomposite, was constructed situ growth Cu2O nanoparticles...
The large-scale deployment of non-aqueous amine solution for carbon dioxide (CO2) capture is mainly limited by its high viscosity, even insoluble substances in saturated solution, which may result equipment fouling and pipeline blockage. To avoid this problem, the polyamine 1,5-diamino-2-methyl-pentane (DA2MP) was screened as main absorbent to ensure absorption load. While 2-amino-2-methyl-1-propanol (AMP) used regulator reduce viscosity eliminate substances, dissolved n-propanol (PrOH) from...
Abstract Fast shape‐reconfiguration with large morphing amplitude is crucial for intelligent materials/structures that require tunable functions and adaptivity to different environments. However, the strategies are rare in combining ultrafast speed, amplitude, high energy‐efficiency simultaneously. Herein, a class of 2D 3D chiral mechanical metamaterials proposed tackle this challenge based on prestressed bistable metallic shells. The metamaterial architected by cylindrical cores slender...
Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options drug delivery with their tunable loading release To take advantage of the features carrier polymers, we present one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained PVA core silk shell after system...
Abstract Re‐customizable mechanical behavior is critical for versatile materials with tunable functions and applications, but inverse design varying targets often hindered by complex coupling between structural topologies mechanics. In this work, a novel “stair‐building” strategy customizing as well re‐customizing target metamaterials proposed. Similar to building stair bricks, or stress–strain (force–displacement) curve the material can be realized stacking brick‐like loading curves of...
Abstract We report the fabrication of an exotic bamboo‐like π‐nanotube via hierarchical self‐assembly a dipeptide‐substituted naphthalenediimide gelator with tunable helicity and circularly polarized luminescence (CPL). It was found that in presence trifluoroacetic acid (TFA) molecules self‐assembled into π‐nanotube, which is composed truncated nanocones CPL active. When defining diameter ratio lower to upper edge each nanocone as parameter express different nanotubes, it both these...