A5081959417- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- interferon and immune responses
- Gout, Hyperuricemia, Uric Acid
- Drug-Induced Hepatotoxicity and Protection
- Protein Degradation and Inhibitors
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Curcumin's Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Liver physiology and pathology
Chinese People's Liberation Army
2021-2024
Chinese PLA General Hospital
2021-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Graphical Abstract GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce expression type I interferon pro-inflammatory cytokines. Meanwhile also has a good therapeutic effect on sepsis contributed to cecum ligation puncture.
The polysaccharide extract from Isatidis Radix exhibits potent antiinflammatory and antiviral activities, but the mechanism of (IRP) remains obscure. Herein, we reported that IRP blocked activation nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, leading to inhibiting caspase-1 cleavage IL-1β secretion. Mechanistically, did not inhibit NLRP3 inflammasome through suppressing mitochondrial reactive oxygen species (mtROS) production. However, can significantly suppress...
ER-phagy, a selective autophagy targeting the endoplasmic reticulum (ER) for lysosomal degradation through cargo receptors, plays critical role in ER quality control and is linked to various diseases. However, its physiological pathological roles remain largely unclear due lack of animal model studies. This study establishes Drosophila as an vivo ER-phagy model. Starvation triggers across multiple fly tissues. Disturbing by either globally upregulating or downregulating Atl Rtnl1, harms fly....
Liver fibrosis is an abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Chronic injury leads to release inflammatory cytokines and reactive oxygen species (ROS) from damaged hepatocytes, which activates hepatic stellate cells (HSCs) secrete extracellular matrix proteins, thereby leading fibrosis. Thus, inhibition hepatocyte HSC activation, promotion apoptosis activated HSCs are important strategies for prevention In this study, we showed that...
Reticulophagy, which directs the endoplasmic reticulum (ER) to phagophore for sequestration within an autophagosome and subsequent lysosomal degradation via specific receptors, is essential ER quality control implicated in various diseases. This study utilizes
Abstract Sepsis is a disease of multiple organ dysfunction caused by infection. It threatens human health and one the major mortality problems. Recent researches have shown that cGAS-STING pathway involved in development progression sepsis. Here, we report Glycyrrhiza Uralensis Polysaccharides (GUP), components licorice, has protective effect against cecal ligation puncture (CLP) sepsis mice. We found GUP reduced pathological changes CLP sepsis-inducing tissues expression genes downstream...
Ethnopharmacological relevance: Psoralea corylifolia is a traditional Chinese medicine, has significant effects as an aphrodisiac, diuretic, and anti-rheumatic. However, it been reported to cause hepatic injury the precise mechanisms remain unclear.Aim of study: To evaluate safety risk elucidate underlying drug-induced liver injury.Materials methods: Western blot, ELISA kits, Immunofluorescence, Q-PCR Flow cytometry were used explore effect Bakuchiol on AIM2 inflammasome activation...