A5053111614- RNA regulation and disease
- CRISPR and Genetic Engineering
- Glaucoma and retinal disorders
- RNA Research and Splicing
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Retinal Development and Disorders
- GABA and Rice Research
- Connective tissue disorders research
- Corneal surgery and disorders
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Retinal Diseases and Treatments
- interferon and immune responses
- Connexins and lens biology
- Epigenetics and DNA Methylation
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Corneal Surgery and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Clostridium difficile and Clostridium perfringens research
- Advanced biosensing and bioanalysis techniques
- Bipolar Disorder and Treatment
Jiangnan University
2017-2025
Institute of Zoology
2021-2025
Guangdong Academy of Sciences
2021-2024
Jiangxi Academy of Sciences
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
State Grid Corporation of China (China)
2024
Anhui University of Traditional Chinese Medicine
2024
Taipei Medical University
2024
Taipei Medical University-Shuang Ho Hospital
2024
Circadian rhythm misalignment due to social jet lag, shift work, early morning starts, and delayed bedtimes is becoming common in our modern society. Disturbances of sleep the underlying circadian rhythms are related multiple human diseases, such as obesity, diabetes, cardiovascular disorders, cognitive impairments. Given crucial role microbiota same pathologies caused by disturbance, how gut affected increasing interest. The results this study indicate that acute disturbance sleep-wake...
Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions abnormalities remains be further elucidated. Here we conducted a prospective feeding experiment evaluate effects of dietary fat-to-sugar ratio on diet-induced adult cynomolgus monkeys. Four groups monkeys were fed regular chow plus emulsion with combinations high (HS) or low (LF) (HF) for 7 months. Plasma levels total cholesterol (TC), low-density lipoprotein...
Abstract Background Solute Carrier Family 31 Member 1 ( SLC31A1 ) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that may play role in colorectal and lung cancer tumorigenesis. However, the of its functions multiple tumor types remains to be further elucidated. Methods Online websites datasets such HPA, TIMER2, GEPIA, OncoVar, cProSite were used extract data on cancers. DAVID BioGRID conduct functional analysis construct protein–protein...
COVID-19 might cause neuroinflammation in the brain, which could decrease neurocognitive function. We aimed to evaluate causal associations and genetic overlap between intelligence.We performed Mendelian randomization (MR) analyses assess potential three outcomes intelligence (N = 269 867). The COVID phenotypes included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection 501 486), hospitalized 1 965 329) critical 743 167). Genome-wide risk genes were compared genome-wide...
ABSTRACT Mycoplasma pneumoniae is an important human respiratory pathogen that causes mild-to-moderate community-acquired M. pneumonia (MPP), particularly in children. RNA editing plays a vital role infection and host immune response, but it remains largely unknown how could be involved the epigenetic regulation of response to infection. In present study, we performed epitranscriptomic analysis adenosine inosine (A-to-I) 39 bronchoalveolar lavage fluid (BALF) samples from severe side (SS)...
Abstract Background To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) intraocular pressure (IOP) Chinese cohort. Methods In total 248 unrelated individuals including 30 juvenile-onset (JOAG), 92 adult-onset (AOAG) 126 sex-matched senile cataract controls, underwent comprehensive...
Abstract Recent population studies have significantly advanced our understanding of how age shapes the gut microbiota. However, actual role could be inevitably confounded due to complex and variable environmental factors in human populations. A well-controlled environment is thus necessary reduce undesirable confounding effects, recapitulate age-dependent changes microbiota healthy primates. Herein we performed 16S rRNA gene sequencing, characterized age-associated microbial profiles from...
Ophthalmic manifestations have recently been observed in acute and post-acute complications of COVID-19 caused by SARS-CoV-2 infection. Our precious study has shown that host RNA editing is linked to viral infection, yet ocular adenosine inosine (A-to-I) during infection remains uninvestigated COVID-19. Herein we used an epitranscriptomic pipeline analyze 37 samples investigate A-to-I associated with five tissue types including the conjunctiva, limbus, cornea, sclera, retinal organoids....
Purpose.: Genome-wide association studies have shown of the atonal homolog 7 (ATOH7) and raftlin lipid raft linker 1 (RFTN1) genes with glaucoma-related optic disc parameters. ATOH7 RFTN1 sequence variations were investigated in patients primary open-angle glaucoma (POAG) their relationships vertical cup-to-disc ratio (VCDR) central corneal thickness (CCT) determined. Methods.: In 289 unrelated controls 142 adult-onset POAG, including 117 high-tension (HTG) 25 normal-tension (NTG), single...
Cataracts are a significant public health problem with no proven methods for prevention. Discovery of novel disease mechanisms to delineate new therapeutic targets is importance in cataract prevention and therapy. Herein, we report that mutations the RagA GTPase (RRAGA), key regulator mechanistic rapamycin complex 1 (mTORC1), associated autosomal dominant cataracts. We performed whole exome sequencing family juvenile-onset cataracts, identified p.Leu60Arg mutation RRAGA co-segregated...
Background Microbial infection is accompanied by remodeling of the host transcriptome. Involvement A-to-I RNA editing has been reported during viral but remains to be elucidated intracellular bacterial infections. Results Herein we analyzed infections based on 18 RNA-Seq datasets 210 mouse samples involving 7 tissue types and 8 pathogens (IBPs), identified a consensus signature for IBP infections, mainly neutrophil-mediated innate immunity lipid metabolism. Further comparison patterns...
Background Non-coding single nucleotide polymorphisms (SNPs) in GABRB2, the gene for β2-subunit of gamma-aminobutyric acid type A (GABAA) receptor, have been associated with schizophrenia (SCZ) and quantitatively correlated to mRNA expression alternative splicing. Methods Findings Expression Exon 10 region GABRB2 from minigene constructs revealed this be an “alternative splicing hotspot” that readily gave rise differently spliced isoforms depending on intron sequences. This led a search...
The SCZ (schizophrenia)-associated GABAA receptor (γ-aminobutyric acid type A receptor) β2 subunit gene GABRB2 was recently associated with BPD (bipolar disorder). Although weaker than its association SCZ, significant of found in both German and Chinese, especially for the haplotypes rs1816071–rs187269 rs1816072–rs187269 which M–M variants showed higher frequency disease control. Significant genotype-dependent reduction expression shown BPD, but to a lesser extent that SCZ. Temporal effects...
The occurrence of positive selection in schizophrenia-associated GABRB2 suggests a broader impact the gene product on population fitness. present study considered possibility cognition-related involvement by examining association with psychosis and altruism, respectively representing psychiatric psychological facets social cognition. Four single nucleotide polymorphisms (SNPs) were genotyped for quantitative trait analyses population-based studies. Psychosis was measured either Positive...
The IDH somatic mutation status is an important basis for the diagnosis and classification of gliomas. We proposed a "6-Step" general radiomics model to noninvasively predict by simultaneously tuning combined multi-sequence MRI optimizing full processing pipeline. Radiomic features (n = 3776) were extracted from (T1, T2, FLAIR, T1Gd) in low-grade gliomas (LGGs), total 45,360 pipeline investigated according different settings. predictive ability was evaluated with regards accuracy, stability,...
The process of immune photothermal therapy.
The gamma-aminobutyric acid type-A (GABA(A)) receptor plays a major role in inhibitory neurotransmissions. Intronic SNPs and haplotypes GABRB2, the gene for GABA(A) beta(2) subunit, are associated with schizophrenia correlated expression of two alternatively spliced isoforms. In present study, using chimpanzee as an ancestral reference, high frequencies were observed derived (D) alleles four rs6556547, rs187269, rs1816071 rs1816072 suggesting occurrence positive selection these alleles....