Ruofan Jia

ORCID: 0000-0002-6264-1220
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Research Areas
  • Sexual Differentiation and Disorders
  • Growth Hormone and Insulin-like Growth Factors
  • RNA modifications and cancer
  • Hormonal and reproductive studies
  • Hypothalamic control of reproductive hormones
  • Ferroptosis and cancer prognosis
  • Cancer, Lipids, and Metabolism
  • RNA regulation and disease
  • Personality Traits and Psychology
  • Sperm and Testicular Function
  • Diet and metabolism studies
  • Lipid metabolism and disorders
  • Cytomegalovirus and herpesvirus research
  • Personality Disorders and Psychopathology
  • Emotional Intelligence and Performance
  • Cancer-related molecular mechanisms research
  • CRISPR and Genetic Engineering
  • Drug Transport and Resistance Mechanisms
  • Blood groups and transfusion
  • Metabolism and Genetic Disorders
  • Circular RNAs in diseases
  • Urologic and reproductive health conditions

Jiangnan University
2021-2024

Wuxi Fourth People's Hospital
2022-2024

Xi'an Jiaotong University
2022

Abstract Background Solute Carrier Family 31 Member 1 ( SLC31A1 ) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that may play role in colorectal and lung cancer tumorigenesis. However, the of its functions multiple tumor types remains to be further elucidated. Methods Online websites datasets such HPA, TIMER2, GEPIA, OncoVar, cProSite were used extract data on cancers. DAVID BioGRID conduct functional analysis construct protein–protein...

10.1186/s12920-023-01489-9 article EN cc-by BMC Medical Genomics 2023-03-27

Polycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to variety diseases, its role PCOS remains unclear. A discovery RNA-Seq dataset was obtained from the NCBI Gene Expression Omnibus database granulosa cells with and without (controls). validation downloaded European Nucleotide Archive Databank used validate differential editing. Transcriptome-wide investigation conducted analyze adenosine-to-inosine...

10.3389/fendo.2023.1170957 article EN cc-by Frontiers in Endocrinology 2023-07-21

This study attempted to explore the personality traits of higher achievers at university level. The core objective this investigation was illustrate nature achievers' students. To phenomenon, a quantitative research approach used. students were chosen by using purposive sampling technique and included 758 high enrolled in various programs Chinese universities. Based on Hexaco model personality, questionnaire used gather information from respondents as tool examine position holders after an...

10.3389/fpsyg.2022.881491 article EN cc-by Frontiers in Psychology 2022-04-15

The growth potential in pubertal boys with short stature is limited by the effect of estrogen on epiphyseal fusion. This study aims to identify efficacy and safety combination hormone (GH) letrozole adult height (AH) stature.This a retrospective record based study. Pubertal who were treated GH followed up at outpatient clinics our hospital. Twenty subjects reached AH are reported here.Baseline chronological age was 12.12 ± 1.14 yr bone 13.00 0.93 yr. period GH/letrozole treatment 1.94 0.67...

10.1186/s12887-022-03438-4 article EN cc-by BMC Pediatrics 2022-06-28

To investigate the diagnostic value of urine luteinizing hormone (ULH) after triptorelin stimulation test detected by immunochemiluminometric assay (ICMA) in girls with central precocious puberty (CPP).

10.1055/a-2316-4772 article EN Experimental and Clinical Endocrinology & Diabetes 2024-04-29

Abstract Background Solute Carrier Family 31 Member 1 ( SLC31A1 ) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that may play role in colorectal and lung cancer tumorigenesis. However, the of its functions multiple tumor types remains to be further elucidated. Methods In this study, we used some website tools such HPA, GEPIA2 cBioPortal estimate expression, genetic alteration prognostic types. TIMER2 was evaluate cancer-associated fibroblast...

10.21203/rs.3.rs-2204544/v1 preprint EN cc-by Research Square (Research Square) 2022-11-08

There is still no consensus on the optimal monitoring method to evaluate hypothalamic-pituitary-gonadal axis (HPGA) inhibition.There were 124 girls treated with triptorelin depot due puberty disorders, including 77 central precocious and 47 early puberty. After treatment, stimulation tests performed, blood samples collected at 0, 20, 40 60 min. Luteinizing hormone (LH) follicle-stimulating (FSH) measured by immunochemiluminometric assay (ICMA).Peak LH (PLH), peak FSH estradiol in...

10.1080/00365513.2022.2148120 article EN Scandinavian Journal of Clinical and Laboratory Investigation 2022-11-24

Abstract Background Polycystic ovary syndrome (PCOS) is a common female endocrinal disease that may result in excessive androgen, but the mechanism of PCOS remains unclear. Most patients with suffer from low-grade inflammation, whereas underlying connection between immune and still uncertain. Objective This study aimed to determine immune-related mechanisms behind pathogenesis explore distinct genes their functional signatures PCOS. Methods The microarray dataset GSE155489 was downloaded...

10.21203/rs.3.rs-2083076/v1 preprint EN cc-by Research Square (Research Square) 2022-09-22

Abstract BackgroundThe growth potential of pubertal short stature boys is limited by the effect estrogen on epiphyseal fusion. This study aims to identify efficacy and safety hormone (GH) combination with letrozole final adult height (FAH) in boys. MethodsThis a retrospective study. Among who treated GH were be followed up our hospital, 20 cases reached FAH. ResultsBaseline chronological age 12.12±1.14yr, bone 13.00±0.93yr. The treatment duration was 1.94±0.67yr. standard deviation score for...

10.21203/rs.3.rs-473221/v1 preprint EN cc-by Research Square (Research Square) 2021-05-07
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