A5101559888- Traditional Chinese Medicine Analysis
- Renal Diseases and Glomerulopathies
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Endometrial and Cervical Cancer Treatments
- Phytochemistry and Biological Activities
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Gynecological conditions and treatments
- Business Process Modeling and Analysis
- Cardiac Fibrosis and Remodeling
- Silkworms and Sericulture Research
- Medicinal Plants and Neuroprotection
- Galectins and Cancer Biology
- Machine Learning in Healthcare
- Thyroid Disorders and Treatments
- Lipid metabolism and disorders
- Ubiquitin and proteasome pathways
- Intracerebral and Subarachnoid Hemorrhage Research
- T-cell and B-cell Immunology
- Maternal and fetal healthcare
- Tuberous Sclerosis Complex Research
- Medicinal Plants and Bioactive Compounds
Guangzhou University of Chinese Medicine
2016-2025
University of South China
2023-2025
Shuguang Hospital
2023
Shanghai University of Traditional Chinese Medicine
2023
University of Cincinnati
2023
Zhengzhou University of Light Industry
2021-2023
Jiangnan University
2023
Wuxi Fourth People's Hospital
2023
Nanjing General Hospital of Nanjing Military Command
2019
Nanjing Drum Tower Hospital
2019
Abstract Background Solute Carrier Family 31 Member 1 ( SLC31A1 ) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that may play role in colorectal and lung cancer tumorigenesis. However, the of its functions multiple tumor types remains to be further elucidated. Methods Online websites datasets such HPA, TIMER2, GEPIA, OncoVar, cProSite were used extract data on cancers. DAVID BioGRID conduct functional analysis construct protein–protein...
The pathogenesis of renal fibrosis is related to blood stasis, and the method promoting circulation removing stasis often used as treatment principle. Danshen injection (DSI) a commonly drug for in clinic. However, whether DSI slows progression or potential mechanism uncertain. We investigated models using UUO mice TGF-β stimulation HK-2 cells. Our findings revealed that Fer-1 alleviated kidney injury by ameliorating morphology pathological vivo. Besides, inhibited vivo TGF-β-induced...
Lupus nephritis (LN) is one of the most common and severe manifestations systemic lupus erythematosus, leading to permanent renal damage chronic kidney disease. Hydroxychloroquine (HCQ) serves a protective role against lupus-associated clinical medical complications; however, it results in numerous adverse reactions, limiting its long‑term use. The aim present study was investigate combined effect HCQ artemisinin (ART) on LN, elucidate underlying mechanisms. An vivo LN mouse model prepared,...
CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC metastasis. Here, we showed that stable knockdown SMMC-7721 cells, p14ARF tumor suppressor was upregulated at mRNA levels, ectopic expression found to repress the transcription p14ARF. Using chromatin immunoprecipitation assay, demonstrated bound...
Platelet-derived growth factor receptor β (PDGFRβ) dynamically changes after brain injury, possibly mediating the neuroprotective role of soluble homodimers platelet-derived subunit (PDGF-BB) that is secreted by microcirculation cells. The aim this study was to determine whether binding PDGF-BB astrocytic PDGFRβ enhanced crosstalk among various components neurovascular unit, leading synaptic recovery subarachnoid hemorrhage (SAH). from cerebrospinal fluid (CSF) patients with SAH measured....
In this study, the ultrasound-assisted extraction (UAE) of flavonoid from Paeonia lactiflora seed peel was optimized by response surface methodology (RSM). Single-factor experiments and a three-factor three-level Box-Behnken design (BBD) were performed to explore effects following parameters on extraction: ethanol concentration ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <msub> <mrow> <mi>X</mi> </mrow> <mn>1</mn> </msub> </math> ), liquid-solid ratio id="M2"> <mn>2</mn>...
Large language models (LLMs) have demonstrated remarkable progress in healthcare. However, a significant gap remains regarding LLMs' professionalism domain-specific clinical practices, limiting their application real-world diagnostics. In this work, we introduce ZODIAC, an LLM-powered framework with cardiologist-level designed to engage LLMs cardiological ZODIAC assists cardiologists by extracting clinically relevant characteristics from patient data, detecting arrhythmias, and generating...
Introduction:The TASER X26 is an electronic control device used by law enforcement to resisting suspects.There has been controversy in the lay press because these devices have temporally associated with some sudden in-custody deaths.This first study examine effects of multiple, simultaneous discharges humans.Methods and results: Human volunteers were exposed multiple (two three), 5-s from X26.Applications chest, back, abdomen, or thighs.Blood was analysed before 24 h after discharge for...
The present study is to establish the fingerprints for quality evaluation of Ilicis Pubescentis Radix by HPLC-UV. chromatographic conditions were defined as Phenomenex Luna C₁₈(4.6 mm × 250 mm, 5 μm). Mobile phase was acetonitrile-0.05% phosphoric acid in gradient elution, and flow rate 0.8 mL·min⁻¹.Column temperature 30 °C injection volume 10 μL．The detection wavelength 210 nm. According similarity evaluation, chemometric method used assess Radix. 16 batches established. There 29 common...