A5103051601- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Metabolism and Genetic Disorders
- Reproductive System and Pregnancy
- Plant Molecular Biology Research
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Systemic Sclerosis and Related Diseases
- Dialysis and Renal Disease Management
- ATP Synthase and ATPases Research
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Disease Resistance and Genetics
- Insect Resistance and Genetics
- Calcium signaling and nucleotide metabolism
- Heavy Metal Exposure and Toxicity
Huazhong University of Science and Technology
2024
University of South China
2024
Tongji Hospital
2024
Agricultural Genomics Institute at Shenzhen
2023
Ministry of Agriculture and Rural Affairs
2023
Chinese Academy of Agricultural Sciences
2023
Guangzhou University of Chinese Medicine
2016-2022
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2022
First Affiliated Hospital of Henan University
2020
Shandong University
2020
Acute kidney injury (AKI) is a serious disease characterized by rapid decline in function. Oxidative stress the primary pathogenesis of AKI. Salvianolic acid B (SalB), water-soluble compound extracted from Salvia miltiorrhiza, possesses potent antioxidant activity. Here, we investigated protective effect SalB against renal ischemia-reperfusion (I/R) mice. Briefly, analyzing function, oxidative markers and inflammatory biomarkers, found that could improve damage, reduce factor levels....
Mesangial proliferative glomerulonephritis (MsPGN) is the most common type of chronic kidney diseases in China, characterized by mesangial cells proliferation and inflammatory response. Paeoniflorin, an effective composition extracted from Radix Paeoniae Alba, has been used for various kinds many years. However, there are no studies reporting effects paeoniflorin on MsPGN. The present study aimed to investigate whether plays a role MsPGN confirm underlying molecular mechanisms. Our results...
Renal fibrosis is a kind of progressive kidney disease leading to end-stage renal damage. Epithelial-mesenchymal transition (EMT) one the crucial features fibrosis. Salvianolic acid B (SalB), isolated from traditional Chinese medicine Radix Salviae miltiorrhizae, has been proved be suitable for protection. The aims this study are investigate pharmacological effects SalB on and explore underlying mechanisms. In vivo, our showed that could improve dysfunction reduce expression EMT-related...
Background: Distinguishing light-chain cardiac amyloidosis (AL CA) from left ventricular wall thickening (LVWT) resulted other etiologies has proven to be challenging. This study aimed determine the sensitivity and specificity of relative apical sparing in diagnosing AL CA investigate differences clinical echocardiographic characteristics between patients with those non-apical sparing.
Summary Lettuce is one of the most important vegetables worldwide. Bolting time an agronomic trait in lettuce production. Premature bolting reduces crop quality and marketability. Here, we genetically clone LsBLH2 gene controlling lettuce. encodes a BEL1‐like homeodomain protein. In late parent, had 1‐bp deletion exon 1 which leads to premature stop codon. CRISPR/cas9 knocking out complementary tests showed that loss‐of‐function delays ChIP‐seq, expression phytohormone analysis regulates...
The present study is designed to investigate the protective effects of <italic>Cordyceps militaris</italic> polysaccharides (CMP) on STZ-treated DN mice.
Immunoglobulin A nephropathy (IgAN) is one of the most frequent kinds primary glomerulonephritis characterized by IgA immune complexes deposition and glomerular proliferation. Zhen-wu-tang (ZWT), a well-known traditional Chinese formula has been reported to ameliorate various kidney diseases. However, its pharmacological mechanism remains unclear. Exosomes have described in diverse renal diseases mediating cellular communication but rarely IgAN. The purpose present study explore whether...
Immunoglobulin A nephropathy (IgAN), an autoimmune renal disease with complicated pathogenesis, is one of the principal reasons for end-stage in clinic. Evidence has linked apparent alterations components microbiome and metabolome to rats. However, thus far, there insufficient evidence that supports potential relationship between gut microbiome, circulating metabolites, IgAN. This study was designed probe effects IgAN on intestinal microecology metabolic phenotypes understand possible...
As an essential trace element for organisms, zinc participates in various physiological processes, such as RNA transcription, DNA replication, cell proliferation, and differentiation. The destruction of homeostasis is associated with diseases. Zinc controlled by the cooperative action transporter proteins that are responsible influx efflux zinc. mainly categorized into two families: Zrt/Irt-like protein (SLC39A/ZIP) family (SLC30A/ZNT) family. ZIP transporters contain 14 members, namely...
Lupus nephritis (LN) is one of the most common and severe manifestations systemic lupus erythematosus, leading to permanent renal damage chronic kidney disease. Hydroxychloroquine (HCQ) serves a protective role against lupus-associated clinical medical complications; however, it results in numerous adverse reactions, limiting its long‑term use. The aim present study was investigate combined effect HCQ artemisinin (ART) on LN, elucidate underlying mechanisms. An vivo LN mouse model prepared,...
Astragaloside IV(AS‐IV), a saponin purified from Astragalus membranaceus ( Fisch .) Bge.var.mongholicus (Bge.) Hsiao, has been widely used in traditional Chinese medicine. However, the underlying mechanisms treating chronic glomerular nephritis (CGN) have not fully understood. The aim of present study was to evaluate potential mechanism AS‐IV on CGN. CGN rats were administrated with at 10 mg·kg −1 ·d (ASL) and 20 (ASH). Twenty four hour proteinuria, blood urea nitrogen (BUN), serum...
Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia and edema. The disorder of sodium water metabolism a critical mechanism regulating the origination progression NS. Zhen-wu-tang (ZWT) has been traditionally used to treat edema disease in China Japan. present study was carried out assess protective effect ZWT Adriamycin-induced (ADR) NS rats investigate potential anti-NS mechanisms ZWT. We found that treatment ameliorate impaired kidney function regulate balance kidney....
<b><i>Objective:</i></b> This study is aimed at examining the effects of Maxing Shigan Tang (MST) treatment on H1N1-associated acute lung injury (ALI) and exploring possible mechanism. <b><i>Material Methods:</i></b> Mice were randomly divided into a control group, model peroxisomal proliferator activator receptor &#x03B3; (PPAR&#x03B3;) inhibition group (PPAR&#x03B3;-), PPAR&#x03B3; activation (PPAR&#x03B3;+), MST group....
ABSTRACT Aims/Introduction To assess the effect of empagliflozin treatment on left ventricular (LV), right (RV) and atrial (LA) functions in diabetes patients with normal ejection fraction. Materials Methods The study included a total 128 multiple cardiovascular risk factors who were subjected to 6‐month follow up from initiation treatment. Before after empagliflozin, LV, RV LA strain, noninvasive myocardial work parameters evaluated by speckle tracking echocardiography. Results In (mean age...
The artificially synthesized strigolactone (SL) analogue GR24 is currently the most widely used reference compound in studying biological functions of SLs. To elucidate structure-activity relationship and find more promising derivatives with unique molecular profiles, we design three series novel explored their activities hypocotyl root development Arabidopsis. Among 50 compounds, A11a, A12a, A20d were found to have high comparable for and/or primary elongation inhibition Some new analogues...