A5065053715- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Aldose Reductase and Taurine
- Genomics, phytochemicals, and oxidative stress
- Nuclear Receptors and Signaling
- Molecular spectroscopy and chirality
- Flavonoids in Medical Research
- Chronic Kidney Disease and Diabetes
- Biochemical Acid Research Studies
- Renal Diseases and Glomerulopathies
- RNA Research and Splicing
- Connective Tissue Growth Factor Research
- Circular RNAs in diseases
- Hydrogen's biological and therapeutic effects
- Phytochemicals and Medicinal Plants
- Graphene and Nanomaterials Applications
- Pregnancy and preeclampsia studies
- Axial and Atropisomeric Chirality Synthesis
- Phytochemistry and Biological Activities
- Seaweed-derived Bioactive Compounds
- Carbon and Quantum Dots Applications
- Protein Hydrolysis and Bioactive Peptides
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Arrest and Resuscitation
Hainan University
2019-2024
Guangdong Food and Drug Vocational College
2019-2020
Hainan General Hospital
2020
General Hospital of Shenyang Military Region
2018
Mesangial proliferative glomerulonephritis (MsPGN) is the most common type of chronic kidney diseases in China, characterized by mesangial cells proliferation and inflammatory response. Paeoniflorin, an effective composition extracted from Radix Paeoniae Alba, has been used for various kinds many years. However, there are no studies reporting effects paeoniflorin on MsPGN. The present study aimed to investigate whether plays a role MsPGN confirm underlying molecular mechanisms. Our results...
Diabetic cardiomyopathy (DCM) is one of the leading causes death in diabetic patients, and accompanied by increased oxidative stress mitochondrial dysfunction. Fucoxanthin (FX), as a marine carotenoid, possesses strong antioxidant activity. The main purpose our study was to explore whether FX could attenuate experimental cardiac hypertrophy affecting mitophagy stress. We found that improved lipid metabolism, myocardial damage, fibrosis tissue STZ-induced rats. Additionally, upregulated Nrf2...
As one of the main marine carotenoids, fucoxanthin has strong antioxidant activity. FoxO3α, a member forkhead box O family transcription factors, plays an important role in DN by regulating oxidative stress. The activity FoxO3α is related to its phosphorylation and acetylation status, regulated Akt Sirt1, lysine deacetylase. Our study aimed investigate whether could alleviate stress fibrosis via Sirt1 were involved. We found that GMCs cultured HG, treatment significantly reduced expression...
Severe lung damage is a major cause of death in blast victims, but the mechanisms pulmonary injury are not well understood. Therefore, it important to study mechanism injury. A model induced by exposure was established using simulation device. The effectiveness and reproducibility device were investigated. Eighty mice randomly divided into eight groups: control group 3 h, 6 12 24 48 7 days 14 post blast. explosive an explosion single mice. success rate as high 90%, degree basically same...
Diabetic nephropathy (DN) is one of the major microvascular complications diabetes, and mitochondrial dysfunction has been observed in kidneys diabetic patients. Tilapia skin peptides (TSPs) are mixtures small-molecular-weight derived from tilapia skin. Rising evidence suggests that bioactive marine sources beneficial for DN. This study aimed to investigate whether TSPs can alleviate pathological progress experimental DN by improving through activation Bnip3/Nix signaling. In current study,...
Abstract Pathological myocardial fibrosis and hypertrophy occur due to chronic cardiac stress. The microRNA‐27a (miR‐27a) regulates collagen production across diverse cell types organs inhibit could constitute an important therapeutic avenue. However, its impact on remodelling is less well‐known. We employed a transverse aortic constriction (TAC) murine model of left ventricular pressure overload investigate the in vivo effects genetic miR‐27a knockout, antisense inhibition miR‐27a‐5p...
• Fx improves renal function, lipid metabolism and fibrosis in diabetic rats. regulates p62/Keap1/Nrf2 pathway kidneys of rats HG-induced GMCs. LC3 promotes interaction between p62 Keap1 mitochondrial morphology levels MMP mtROS Fucoxanthin (Fx) has a unique chemical structure that confers its biological effects shows potential health benefits. The main purpose this study was to explore whether could alleviate nephropathy (DN) by regulating signaling improving damage. We found improved...
To investigate the protective effect of fucoxanthin (FX) against diabetic cardiomyopathy and explore underlying mechanism.Rat models diabetes mellitus (DM) induced by intraperitoneal injection streptozotocin (60 mg/kg) were randomized into DM model group, treatment (DM+FX) group metformin (DM+ Met) normal rats with feeding served as control group. In two groups, administered after modeling gavage at daily dose 200 mg/kg 230 mg/kg, respectively for 12 weeks, in given saline only. HE staining...
It is acknowledged that hepatocellular carcinoma (HCC) cause the most cancer-associated mortality all around world and traditional Chinese medicine has been widely used in HCC treatment. Physalin B (PB) important chemical compounds of a herb, Physalis alkekengi var. franchetii . In this research, it first time we illustrated PB exhibits obvious apoptotic activity SMMC-7721 HepG2 human cell lines does-dependent way. Moreover, decrease mitochondrial membrane potential (MMP) was found cellular...