A5028386179- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Treatments and Mutations
- Nitric Oxide and Endothelin Effects
- Wound Healing and Treatments
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Lung Cancer Research Studies
- Effects of Radiation Exposure
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Disaster Response and Management
- Lung Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Chemotherapy-induced organ toxicity mitigation
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
Xinxiang Medical University
2024-2025
Shanghai Jiao Tong University
2025
Shenyang Medical College
2021-2024
Hebei GEO University
2023
China Medical University
2021-2023
Qilu Hospital of Shandong University
2004-2022
General Hospital of Shenyang Military Region
2013-2022
Northeastern University
2019-2022
Shenyang Agricultural University
2022
Henan Provincial People's Hospital
2020-2021
Circular RNA (circRNA) is a subclass of non-coding RNAs that enables the circular transcripts resistant to exonuclease digestion. Iron homeostasis essential for body maintain normal physiological functions. At present, relationship among circRNA, iron metabolism and heart failure remains largely unknown. This study aimed explore regulatory mechanism circRNA in failure. We obtained miRNA mRNA data from public databases built ceRNA network. The prediction results were verified myocardial...
Current therapies for heart failure due to transmural left ventricular (LV) infarction are limited. We have developed a novel patch method delivering autologous bone marrow stem cells sites of myocardial the purpose improving LV function and preventing aneurysm formation. The consisted fibrin matrix seeded with porcine mesenchymal labeled lacZ. applied this swine model postinfarction remodeling. Myocardial was produced by using 60-min occlusion anterior descending coronary artery distal...
Chronic unloading of the failing heart with a left ventricular assist device (LVAD) can decrease cardiac mass and myocyte size has potential to improve contractile function. To study effect chronic on myocardial gene expression, microarray (U133A, Affymetrix) profiling expression was compared before after LVAD support in seven patients idiopathic dilated cardiomyopathy end-stage failure. On average, 1,374 ± 155 genes were reported as “increased” 1,629 45 “decreased” support. A total 130...
Activation of AMP-activated protein kinase (AMPK)-α2 protects the heart against pressure overload–induced failure in mice. Although metformin is a known activator AMPK, it unclear whether its cardioprotection acts independently an AMPKα2-dependent pathway. Because role AMPKα1 stimulation on remodeling failing hearts poorly defined, we first studied effects disruption both and AMPKα2 genes response to transverse aortic constriction–induced left ventricular (LV) hypertrophy dysfunction gene...
Because of stem cells are limited by the low efficiency their cell homing and survival in vivo, delivery systems scaffolds have attracted a great deal attention for cells' successful clinical practice. β-chitin nanofibers (β-ChNF) were prepared from squid pens this study. Fourier transform infrared spectroscopy, X-ray diffraction scanning electron microscopy proved that β-ChNFs with diameter 5 to 10 nm prepared. β-ChNF dispersion became gelled upon addition culture medium. Cell experiments...
Parsley, a common vegetable, is widely used as condiment because its flavor. However, biological functionality remains largely ignored. In this study, the antioxidant activity-guided separation method was to obtain four characteristic 7-O-flavonoid glycosides from parsley. An excessive fatigue mouse model evaluate anti-fatigue effects of different parsley extracts. The results showed that flavonoids could significantly improve related physiological indicators and morphology gastrocnemius...
Abstract N 2 O 5 , a reactive species produced by air discharge plasma, has recently attracted much attention. Due to its high reactivity and solubility, is key molecule in nitrogen fixation processes exhibits promising prospects plasma biomedicine. However, thus far, it not well known how produce efficiently then maintain concentration under the action of fast removal reactions. In view this, production dielectric barrier (DBD) alone combination DBD gliding arc compared this paper. It found...
We sought to explore the effect of blueberry anthocyanins-enriched extracts (BAE) on cyclophosphamide (CTX)-induced cardiac injury. The rats were divided randomly into five groups including normal control, CTX 100 mg/kg, BAE 80mg/kg, CTX+BAE 20mg/kg and 80mg/kg groups. in three BAE-treated administered for four weeks. Seven days after administration, group two intraperitoneally injected with a single dose mg/kg CTX. Cardiac injury was assessed using physiological parameters, Echo,...
Abstract DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5) is an ATP-dependent RNA that overexpressed in various malignancies. Increasing evidence suggests DDX5 participates carcinogenesis and cancer progression via promoting cell proliferation metastasis. However, the functional role of gastric largely unknown. In this study, we observed was significantly up-regulated tissues compared with paired adjacent normal tissues. The expression correlated strongly Ki67 index pathological stage cancer....
Exposure to cold weather is associated with infaust cardiovascular responses, including myocardial infarction and arrhythmias. However, the exact mechanisms of these adverse changes in myocardium under stress are unknown. This study was designed investigate cardiac injury induced by mice. The mice were randomly divided into three groups, normal control (no handling), 1-week 2-week stress. We observed physiological morphological tissues, we measured 3′-nitrotyrosine 4-hydroxynonenal,...
The paired box 6 (Pax6) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands. Homozygous loss Pax6 resulted neonatal death mice, plus eyes malformation cerebral cortex. In patients with heterozygous mutations, reduction thickness frontoparietal cortex was detected, which also observed small eye mice. this study, we found that overexpression increased cortical thickness, especially intermediate zone cortex, conflicts report...
Background Breast cancer (BC) is the most prevalent among women and a leading cause of cancer-related deaths worldwide. Emerging evidence suggests that DNA methylation, well-studied epigenetic modification, regulates various cellular processes critical for development progression holds promise as biomarker diagnosis prognosis, potentially enhancing efficacy precision therapies. Methods We developed robust prognostic model BC based on methylation clinical data from The Cancer Genome Atlas...
Although high-energy phosphate metabolism is abnormal in failing hearts [congestive heart failure (CHF)], it unclear whether oxidative capacity impaired. This study used the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) to determine reserve exists during high workload produced by catecholamine infusion hypertrophied and hearts. Left ventricular hypertrophy (LVH) was ascending aortic banding 21 swine; 9 animals developed CHF. Basal myocardial phosphocreatine (PCr)/ATP measured with...
Congestive heart failure (CHF) is associated with impaired endothelium-dependent nitric oxide (NO)-mediated vasodilation (endothelial dysfunction). We hypothesized that coronary endothelial dysfunction in CHF may be due part to decreased dimethylarginine dimethylaminohydrolase (DDAH), the enzyme degrades endogenous inhibitors of NO synthase (NOS), including asymmetric dimethylarginine. Coronary blood flow and vasodilator response acetylcholine were studied dogs which was produced by rapid...
Objective To investigate the protective effect of chitosan oligosaccharide (COS) on acute lung injury (ALI) caused by blast injury, and explore possible molecular mechanisms. Methods A mouse model injury-induced ALI was established using a self-made explosive device. Thirty mice were randomly assigned to control, + COS groups. An eight-channel physiological monitor used determine index. Enzyme linked immunosorbent assay measure serum inflammatory factors. Hematoxylin-eosin staining, terminal...
Clarifying the role and mechanism of exosome gel in wound repair can provide a new effective strategy for treatment.The cellular responses adipose mesenchymal stem cell-derived exosomes (AMSC-exos) healing ability AMSC-exos-loaded β-chitin nanofiber (β-ChNF) hydrogel were studied vitro mouse fibroblasts cells (L929) vivo rat skin injury model. The transcriptome proteome with use sequenator LC-MS/MS, respectively.80 160 μg/mL AMSC-exos could promote proliferation migration cells. Furthermore,...