A5100622439- Renal Diseases and Glomerulopathies
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- Music and Audio Processing
- Speech and Audio Processing
- Speech Recognition and Synthesis
- Systemic Lupus Erythematosus Research
- Traditional Chinese Medicine Analysis
- Food Waste Reduction and Sustainability
- Plant biochemistry and biosynthesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gout, Hyperuricemia, Uric Acid
- Psychedelics and Drug Studies
- Medicinal Plants and Bioactive Compounds
- Plant Water Relations and Carbon Dynamics
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Lipid metabolism and disorders
- Food Industry and Aquatic Biology
- Cholesterol and Lipid Metabolism
- Kruppel-like factors research
- T-cell and B-cell Immunology
- Therapeutic Uses of Natural Elements
- Ginseng Biological Effects and Applications
Guangzhou University of Chinese Medicine
2019-2025
National University of Singapore
2023-2025
Third Affiliated Hospital of Southern Medical University
2024
Agency for Science, Technology and Research
2023
Bioinformatics Institute
2023
Shandong First Medical University
2023
Northwestern Polytechnical University
2021
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020
Beijing Forestry University
2007-2014
Shanxi Agricultural University
2011
Chronic glomerulonephritis (CGN) is one of the major causes end-stage kidney disease. Zhen-wu-tang (ZWT), as a famous Chinese herbal prescription, widely used in China for CGN therapy clinic. However, mechanism ZWT has not been fully understood. The present study explored therapeutic effect and underlying on mitochondrial function cationic bovine serum albumin (C-BSA)-induced model rats tumor necrosis factor (TNF-α)-damaged mouse podocytes. renal functions were measured by creatinine (Scr)...
Renal fibrosis is a kind of progressive kidney disease leading to end-stage renal damage. Epithelial-mesenchymal transition (EMT) one the crucial features fibrosis. Salvianolic acid B (SalB), isolated from traditional Chinese medicine Radix Salviae miltiorrhizae, has been proved be suitable for protection. The aims this study are investigate pharmacological effects SalB on and explore underlying mechanisms. In vivo, our showed that could improve dysfunction reduce expression EMT-related...
The pathogenesis of renal fibrosis is related to blood stasis, and the method promoting circulation removing stasis often used as treatment principle. Danshen injection (DSI) a commonly drug for in clinic. However, whether DSI slows progression or potential mechanism uncertain. We investigated models using UUO mice TGF-β stimulation HK-2 cells. Our findings revealed that Fer-1 alleviated kidney injury by ameliorating morphology pathological vivo. Besides, inhibited vivo TGF-β-induced...
The present study is designed to investigate the protective effects of <italic>Cordyceps militaris</italic> polysaccharides (CMP) on STZ-treated DN mice.
The abnormal proliferation and inflammatory response of the mesangial cells play a crucial role in progression membranous nephropathy (MN). Herein, this study aimed to investigate therapeutic effect Salvianolic acid B (SalB) on MN-induced abnormalities its underlying mechanisms. MN models were established cationic bovine serum albumin-induced Sprague-Dawley rats lipopolysaccharide-induced human (HMCs). Following SalB microRNA-145-5p antagomir treatment, kidney function was investigated by...
Xuebijing injection (XBJ) is widely used to treat nephrotic syndrome (NS) in clinic, but its bioactive components and therapeutic mechanism are still unclear. In this study, the of XBJ were determined by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS). The effect on NS was evaluated BALB/c mice induced adriamycin (ADR, 10 mg/kg) via a single tail vein. protective podocytes demonstrated using mouse (MPC-5) lipopolysaccharide (LPS, 4...
Astragaloside IV(AS‐IV), a saponin purified from Astragalus membranaceus ( Fisch .) Bge.var.mongholicus (Bge.) Hsiao, has been widely used in traditional Chinese medicine. However, the underlying mechanisms treating chronic glomerular nephritis (CGN) have not fully understood. The aim of present study was to evaluate potential mechanism AS‐IV on CGN. CGN rats were administrated with at 10 mg·kg −1 ·d (ASL) and 20 (ASH). Twenty four hour proteinuria, blood urea nitrogen (BUN), serum...
Background: Endoplasmic reticulum (ER) stress has been shown to play an important role in osteoarthritis (OA). Objective: This study was aimed at assessing the relationship of endoplasmic stress-related glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding homologous (CHOP) concentrations serum/synovial fluid (SF) with disease severity primary knee (pkOA). Methods: Patients pkOA together healthy individuals were consecutively recruited from our hospital. The levels GRP78 CHOP serum...
Abstract Introduction Zhen‐wu‐tang (ZWT) is a traditional Chinese medicine (TCM) formula for the treatment of several kidney diseases. However, due to complexity TCM formula, there lack accurate knowledge chemical constituents ZWT and its bioactive components, as well in vivo metabolic pathway studies. Objectives The composition components along with pathways were investigated by combination profiling serum pharmacochemistry. Methods High‐resolution ultra‐performance liquid...
Abstract BACKGROUND: Soy protein enriched with isoflavones has been linked to various disease‐preventing and health‐promoting activities owing the antihypertensive, hypocholesterolaemic, antiobesity antioxidative properties of isoflavones. The isoflavone profiles soy‐based products are known be highly dependent on chemical physical treatments which have subjected. aim this research was increase efficiency backward extraction soy from bis(2‐ethylhexyl) sodium sulfosuccinate (AOT) reverse...
Complex branching and irregular foliage distribution render the quantitative description of tree crowns a scientific technological challenge. This study explores use fractal geometry to describe crowns. Based on derivation classical model—the Sierpinski tetrahedron—a new method we call comprehensive structural relationships (CSR) is described for estimating dimensions in 3-D space. All possible were examined under scale transformation space expansion modes, resulting 15 relationships. The...
Recently, there is a research trend on ad-hoc microphone arrays. However, most was conducted simulated data. Although some data sets were collected with small number of distributed devices, they not synchronized which hinders the fundamental theoretical to To address this issue, paper presents speech corpus, named Libri-adhoc40, collects replayed Librispeech from loudspeakers by arrays 40 strongly nodes in real office environment. Besides, provide evaluation target for frontend processing...
Recently, speech recognition with ad-hoc microphone arrays has received much attention.It is known that channel selection an important problem of arrays, however, this topic seems far from explored in yet, particularly a large-scale array.To address problem, we propose Scaling Sparsemax algorithm for the arrays.Specifically, first replace conventional Softmax operator stream attention mechanism multichannel end-to-end system Sparsemax, which conducts by forcing weights noisy channels to...