A5101673724- Pharmacogenetics and Drug Metabolism
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Metabolomics and Mass Spectrometry Studies
- Plant nutrient uptake and metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Plant responses to water stress
- Rice Cultivation and Yield Improvement
- PI3K/AKT/mTOR signaling in cancer
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Radiopharmaceutical Chemistry and Applications
- Alcohol Consumption and Health Effects
- Potassium and Related Disorders
- Eicosanoids and Hypertension Pharmacology
- Topological Materials and Phenomena
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Venous Thromboembolism Diagnosis and Management
- Pregnancy and Medication Impact
- Amino Acid Enzymes and Metabolism
- Biosimilars and Bioanalytical Methods
- Psychedelics and Drug Studies
- Species Distribution and Climate Change
- Sulfur Compounds in Biology
National University of Singapore
2021-2025
Chinese Research Academy of Environmental Sciences
2024
Nanjing Agricultural University
2021-2024
Jishou University
2023
Nankai University
2023
Shanghai Medical College of Fudan University
2021-2023
Changshu Institute of Technology
2022
Qiqihar University
2022
Fudan University
2020
Soochow University
2018
Abstract The orbital degrees of freedom play a pivotal role in understanding fundamental phenomena solid-state materials as well exotic quantum states matter including superfluidity and topological semimetals. Despite tremendous efforts engineering synthetic cold-atom, electronic photonic lattices to explore physics, thus far high orbitals an important class materials, namely, higher-order insulators (HOTIs), have not been realized. Here, we demonstrate $$p$$ <mml:math...
Abstract The large intestine harbors microorganisms playing unique roles in host physiology. beneficial or detrimental outcome of host‐microbiome coexistence depends largely on the balance between regulators and responder intestinal CD4 + T cells. We found that ulcerative colitis‐like changes after infection with protist Blastocystis ST7 a mouse model are associated reduction anti‐inflammatory Treg cells simultaneous expansion pro‐inflammatory Th17 responders. These alterations depended...
Background Liver fibrosis is a reversible wound-healing response that can lead to end-stage liver diseases without effective treatment, in which HBV infection major cause. However, the underlying mechanisms for development of HBV-induced remains elusive, and efficacious therapies this disease are still lacking. In present investigation, we investigated effect mechanism green tea polyphenol epigallocatechin-3-gallate (EGCG) on injury fibrosis. Methods The EGCG was examined recombinant cccDNA...
Patients with coronavirus disease 2019 (COVID-19) cardiovascular diseases who are at higher risk of progressing to critical illness should be treated nirmatrelvir/ritonavir (Paxlovid). Ritonavir, the booster in nirmatrelvir/ritonavir, modulates multiple drug metabolizing enzymes and transporters, complicating its use real-world clinics. We aimed apply physiologically-based pharmacokinetic (PBPK) modeling simulate complex drug-drug interactions (DDIs) ritonavir two anticoagulants, rivaroxaban...
Efficient and reasonable utilization of waste biomass resources can not only avoid serious material resources, but also solve the problem environmental pollution. Therefore, development efficient environmentally friendly carbonization technology has important practical significance. Here, activated carbon from orange peel (OAC) is prepared by potassium hydroxide (KOH) activation combined with high-temperature carbonization. The adsorption effects OAC on three different pollutant aqueous...
Abstract Background (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H-indazole-3carboxamide (ADB-BUTINACA) is an emerging synthetic cannabinoid that was first identified in Europe 2019 and entered Singapore's drug scene January 2020. Due to the unavailable toxicological metabolic data, there a need establish urinary metabolite biomarkers for detection of ADB-BUTINACA consumption elucidate its biotransformation pathways rationalizing implications. Methods We characterized metabolites...
Large panicle rice cultivars often fail to fulfill their high-yield potential due the poor grain filling of inferior spikelets (IS), which appears as initially stagnant development and low final seed weight. Understanding mechanism initial stagnancy is important improve IS filling. In this study, superior (SS) were removed from two homozygous japonica varieties (W1844 CJ03) with same sink capacity in an attempt force photosynthate transport IS. The results showed that SS removal increased...
Janus kinase (JAK) inhibitors baricitinib and tofacitinib are recommended by the US National Institutes of Health as immunomodulatory drugs for coronavirus disease 2019 (COVID-19) treatment. In addition, has recently received Emergency Use Authorization from Food Drug Administration, although instruction provided dosing information only adults. Geriatrics with organ dysfunction one most vulnerable cohorts when combating pandemic. The aim present work was to evaluate current strategies...
Abstract Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) and AMP-activated (AMPK) are highly conserved. Compound 991 is an AMPK activator in mammals. However, whether also activates SnRK1 remains unknown. The addition of significantly increased activity desalted extracts from germinating rice seeds vitro. To determine has biological activity, were treated with different concentrations 991. Germination was promoted at low but inhibited high concentrations. effects on germination...
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified being critically implicated in the disposition of abiraterone. aimed to further investigate effects abiraterone on activities OATP1B1 utilizing a validated endogenous biomarker coproporphyrin I (CP-I). utilized OATP1B-transfected cells characterize inhibitory potential against OATP1B-mediated uptake CP-I. Inhibition constant (Ki) was incorporated into our physiologically...
Mountain Zizania latifolia is produced at scale in China, and the edible swollen culm exported to many countries, but little attention has been paid its functional components. In this work, microwave-assisted enzymatic extraction (MAEE) used for first time extract polysaccharides from mountain Z. (PMZL). MAEE conditions optimized by Box-Behnken design-response surface methodology were as follows: 2.4% cellulase, microwaving 6.0 min 607 W, with a liquid-to-solid ratio of 63:1 ml g-1 . Under...
Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with cardiac arrhythmia. The interactions between these TKIs CYP2J2 that is highly expressed in the human heart unknown. In vitro metabolism experiments were performed to characterize CYP2J2-mediated of osimertinib. Unbound distribution coefficient (K<sub>puu</sub>) for both was determined AC16 cardiomyocytes. reversible time-dependent inhibition conducted exogenous endogenous substrates, namely rivaroxaban...
The PAE (Posture-Act-Environment) coding system is a behavior that divides the study of animal into postures, actions, and corresponding environmental factors, they are coded correspondingly. It determines analysis dimension to standardize behavior. To investigate A. davidianus during breeding period, as well their related required conditions, this monitored four pairs in simulated natural pool using an infrared image monitoring recorded changes water quality process system. reproductive...
Abstract We aimed to address factors contributing the pharmacokinetic changes of nirmatrelvir/ritonavir in renal impaired (RI) patients and recommend dosing adjustment via a physiologically‐based (PBPK) modelling approach. A PBPK model was developed Simcyp® Simulator. Sensitivity analysis influence hepatic CYP3A4 intrinsic clearance abundance, as well non‐CYP3A4 metabolism (other human liver microsomes [HLM] CL int ) performed evaluate effects RI on oral nirmatrelvir. Other HLM , most...
Poor grain filling in inferior spikelets (IS), which is influenced by the remobilization of nonstructural carbohydrates (NSC) stored sheath and internode rice plants, limits expected high yield large-panicle rice. NSC from to panicle regulated T6P/SnRK1 pathway. However, rice, it unclear whether IS related mediated signaling. In this study, two cultivars-W1844 CJ03-with distinct differences were used explore physiological mechanism mediating development. Compared W1844, CJ03 showed lower...