A5020748132- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Polysaccharides and Plant Cell Walls
- Osteoarthritis Treatment and Mechanisms
- Multiple Myeloma Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Peptidase Inhibition and Analysis
- Seaweed-derived Bioactive Compounds
- Microbial Metabolism and Applications
- Cancer Mechanisms and Therapy
- Ginseng Biological Effects and Applications
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Biological Activity of Diterpenoids and Biflavonoids
- Genomics, phytochemicals, and oxidative stress
- Microbial Metabolites in Food Biotechnology
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
First Affiliated Hospital of Soochow University
2014-2025
Soochow University
2014-2025
Mudanjiang Medical University
2018-2024
China Agricultural University
2021-2023
East Avenue Medical Center
2022
Changshu Institute of Technology
2019
Union Hospital
2016
Jilin University
2009-2016
Jilin Medical University
2010
Since the incidence rate of malignant melanoma is increasing annually, development drugs against cell metastasis has become more urgent.
To discover novel antioxidants and anticoagulants for the prevention treatment of cardiovascular diseases remains ongoing concern. Sagittaria trifolia is a commonly consumed aquatic vegetable with highly nutritious value wide planting area in China. Polysaccharides are major bioactive constituents, but little information available on anticoagulant potential. In this work, polysaccharide from S. (PST) was modified by sulfation to produce four sulfated derivatives (SPST-1 ∼ 4), their...
// Yuping Tang 1, 2, * , Guisheng Zhou Lijun Yao 3 Ping Xue 4 Danhong Yu 5 Renjie Xu 6 Wen Shi 2 Xin Zhaowei Yan and Jin-Ao Duan 1 Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, University Medicine, Xianyang, 712083, China Jiangsu Nanjing Nanjing, 210023, Department Pharmacy, The First Affiliated Hospital Soochow University, Suzhou, 215006, Changzhou Institute for Food Drug Control, Changzhou, 213000, Children’s to Shaoxing Second Hospital,...
This study aimed to investigate the beneficial effects of ε-Viniferin on hyperglycemia and hyperlipidemia, reveal underlying mechanism.
Abstract Lung cancer is recognized as the leading cause of cancer-related death worldwide, with non-small cell lung (NSCLC) being predominant subtype, accounting for approximately 85% cases. Although great efforts have been made to treat cancer, no proven method has found thus far. Considering β, β-dimethyl-acryl-alkannin (ALCAP2), a natural small-molecule compound isolated from root Lithospermum erythrorhizon. We that adenocarcinoma (LUAD) proliferation and metastasis can be significantly...
Lung cancer is the leading cause of cancer-associated death worldwide and classified into non-small cell lung (NSCLC) small-cell (SCLC). NSCLC accounts for approximately 80%-85% all cases. Chenodeoxycholic acid (CDCA), a primary bile acid, has been reported to inhibit carcinoma proliferation. Here, we aimed determine effects mechanism action CDCA against adenocarcinoma (LUAD).Western blotting quantitative real-time polymerase chain reaction were used evaluate protein mRNA expression levels...
<b><i>Introduction:</i></b> Numerous research works have shown that serum Gal-deficient (Gd) IgA1 levels are increased in IgA nephropathy (IgAN) patients and these a dangerous risk factor for IgAN. A relationship between the gut microbiota IgAN has been reported. Whether participates pathogenesis of was still controversial. <b><i>Methods:</i></b> We evaluated changes flora Gd-IgA1 healthy controls (HCs). investigated both blood urine specimens....
Colorectal cancer is one of the most common malignant tumors with a high rate distant metastasis, postoperative recurrence and mortality. ATPase family AAA domain-containing protein 2 (ATAD2), member family, highly expressed in various cancers, including colorectal cancer. However, whether ATAD2 plays role migration invasion cells remains unknown. In this study, we established knockdown cell lines by RNA interference found that silencing inhibited ability Caco-2 SW-480 cells. Moreover,...
Abstract Ginsenosides (20 S )‐Rg3 and R are famous rare ginsenosides from red ginseng, their configurations in C‐20 different. This study aimed to investigate the protective mechanism of on H 2 O ‐induced H9C2 cells compare activity. The results showed that could increase cell activity levels GSH‐Px, SOD CAT, decrease activities LDH, MDA ROS. Further studies prevent oxidative stress injury by through Keap‐1/Nrf2/HO‐1 pathway. But ML385 counteracts these effects. Interestingly, among results,...
Rheumatoid arthritis (RA) is an essential cause of labor loss and disability for people worldwide. Acanthopanax senticosus polysaccharide (ASPS) one the most important active components from A. senticosus, which exhibits various pharmacological activities such as antioxidation immunomodulation. However, no studies have reported application ASPS in treating RA. This study aims to investigate therapeutic effect on RA reveal its underlying mechanism. The potential against initially verified...
Mountain Zizania latifolia is produced at scale in China, and the edible swollen culm exported to many countries, but little attention has been paid its functional components. In this work, microwave-assisted enzymatic extraction (MAEE) used for first time extract polysaccharides from mountain Z. (PMZL). MAEE conditions optimized by Box-Behnken design-response surface methodology were as follows: 2.4% cellulase, microwaving 6.0 min 607 W, with a liquid-to-solid ratio of 63:1 ml g-1 . Under...
Osteoarthritis (OA) is a slowly progressive joint disease typically seen in middle-age to elderly people. At present, there no ideal agent treat OA. Chenodeoxycholic acid (CDCA) was principal active constituent from animal bile. However, the therapeutic effect of CDCA on OA severity largely unknown. The purpose this study evaluate intra-articular injection rabbit model. induced experimental rabbits by anterior cruciate ligament transection (ACLT) and then were intra-articularly injected with...
Two new ceramides, (3S,4S,5R)-3-octadecanoylamino-4-hydroxy-5-dodecane-2,3,4,5-tetrahydrofuran (1) and (3S,4S,5R)-3-[(2R)-2-hydroxyhexacosanoylamino]-4-hydroxy-5-[(4E)-dodecane-4-ene]-2,3,4,5-tetrahydrofuran (2), together with eight known compounds, eleutheroside A (3), B (4), E (5), 7-hydroxy-6-methoxy-coumarin (6), 6,7-dimethoxycoumarin (7), 5α,8α-epidioxyergosta-6,22-dien-3-ol (8), stigmasterol (9) rutin (10), were isolated from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim)...