A5036321312- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced Surface Polishing Techniques
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Advanced machining processes and optimization
- Perovskite Materials and Applications
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Silk-based biomaterials and applications
- Climate Change and Health Impacts
- Piezoelectric Actuators and Control
- Mycobacterium research and diagnosis
- Fatigue and fracture mechanics
- Air Quality and Health Impacts
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- HIV/AIDS Research and Interventions
- Electric Vehicles and Infrastructure
- Organic Light-Emitting Diodes Research
- Transportation and Mobility Innovations
- Diamond and Carbon-based Materials Research
- Lipid metabolism and biosynthesis
- Chalcogenide Semiconductor Thin Films
- Cancer, Lipids, and Metabolism
University of Strathclyde
2021-2025
Zhejiang University of Technology
2024-2025
Materials Science & Engineering
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xi’an Jiaotong-Liverpool University
2020-2024
Sun Yat-sen University
2021-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2024
City University of Hong Kong
2024
Peking University
2017-2023
Peking University People's Hospital
2017-2023
The role of circular RNA in cancer is emerging. A newly reported HIPK3 (circHIPK3) critical cell proliferation various types, although its non-small lung (NSCLC), has yet to be elucidated. Our results provided evidence that silencing circHIPK3 significantly impaired proliferation, migration, invasion and induced macroautophagy/autophagy. Mechanistically, we uncovered autophagy was upon loss via the MIR124-3p-STAT3-PRKAA/AMPKa axis STK11 mutant lines (A549 H838). STAT3 abrogation as well...
While the potential of patient-derived organoids (PDOs) to predict patients' responses anti-cancer treatments has been well recognized, lengthy time and low efficiency in establishing PDOs hamper implementation PDO-based drug sensitivity tests clinics. We first adapt a mechanical sample processing method generate lung cancer (LCOs) from surgically resected biopsy tumor tissues. The LCOs recapitulate histological genetic features parental tumors have expand indefinitely. By employing an...
Abstract The energy storage mechanism of MnO 2 in aqueous zinc ion batteries (ZIBs) is investigated using four types with crystal phases corresponding to α‐, β‐, γ‐, and δ‐MnO . Experimental theoretical calculation results reveal that all follow the H + Zn 2+ co‐intercalation during discharge, ZnMn O 4 , MnOOH, (SO )(OH) 6 ·4H being main products. formed from intercalation, while MnOOH are intercalation. Charging generates through extraction indicating reversible reactions. study also...
Abstract The long noncoding RNA (lncRNA) MIR22HG has previously been identified as a prognostic marker in hepatocellular carcinoma. Here, we performed comprehensive analysis of lncRNA expression profiles from RNA-Seq data and report that plays similar role lung cancer. Analysis 918 cancer normal tissues cell lines revealed was significantly downregulated cancer; this decreased associated with poor patient survival. bound stabilized the YBX1 protein. Silencing triggered both survival death...
Abstract: The aim of the current study was to test hypothesis that forest bathing would be beneficial for elderly patients with chronic heart failure (CHF) as an adjunctive therapy. Two groups participants CHF were simultaneously sent or urban control area a four-day trip, respectively. Subjects exposed site showed significant reduction brain natriuretic peptide (BNP) in comparison city group and their own baseline levels. values cardiovascular disease related pathological factors, including...
Inflammaging is deeply involved in aging-related diseases and can be destructive during aging. The maintenance of pH balance the extracellular microenvironment alleviate inflammaging repair tissue damage. In this study, hydrogen ion capturing hydrogel microsphere (GMNP) composed mineralized transforming growth factor-β (TGF-β) catalase (CAT) nanoparticles developed via biomimetic mineralization microfluidic technology for blocking NLRP3 cascade axis inflammaging. This GMNP neutralize acidic...
A new passivator, 4-aminophenyl sulfone (APS), containing a Lewis base group (SO), could interact with the uncoordinated Pb 2+ on perovskite surface, which not only reduces trap state density but also induces more p-type surface of film.
Due to the ever-growing concerns on air pollution and energy security, many cities have started update their taxi fleets with electric ones. Although environmentally friendly, rapid promotion of taxis raises problems both drivers governments, e.g., prolonged waiting/charging time, unbalanced utilization charging infrastructures reduced supply due long time. In this paper, we make first effort understand long-term evolving patterns through a five-year study one largest networks in world,...
Cardiovascular disease (CVD) mortality is associated with long-term particulate matter (PM) exposure. However, evidence from large, highly-exposed population cohort and observational-data-based causal inference approaches remains limited.We examined the potential links between PM exposure CVD in South China.580,757 participants were recruited during 2009-2015 followed up through 2020. Satellite-based annual concentrations of PM2.5, PM10, PMcoarse (i.e., PM10 - PM2.5) at 1 km2 spatial...
Silk fibroin, known for its biocompatibility and biodegradability, holds significant promise biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens nanometres to hundreds microns, is critical these uses. This study introduces elliptical vibration micro-turning as a method producing particles the form cutting chips serve carriers A hybrid finite element smoothed particle hydrodynamics (FE-SPH)...
Background: The COVID-19 outbreak in China has created multiple stressors that threaten individuals' mental health, especially among public health workers (PHW) who are devoted to control and prevention work. This study aimed investigate the prevalence of help-seeking associated factors PHW using Andersen's Behavioral Model Health Services Use (BMHSU). Methods: A cross-sectional survey was conducted 9,475 five provinces across between February 18 March 1, 2020. subsample data those reported...
To overcome the precision limitation and environmental impact of current chemical-based production methods for manufacturing silk microfibres used targeted drug delivery, this paper presents a high-precision, scalable, eco-friendly mechanical machining approach to produce such in form discontinuous chips obtained through elliptical vibration turning fibroin film using diamond tool. The length waist width fabricated can be precisely controlled. As each cycle will one microfibre, complete...
Surface passivation using organic molecules with appropriate charge distribution and geometric structure is crucial for achieving high-performance perovskite solar cells. Here, diphenylsulfone (DPS) 4,4′-dimethyldiphenylsulfone (DMPS) a conjugated are introduced at the hole transport layer interface to investigate impact of on interaction between surface. The presence methyl group in DMPS D-π-A optimizes enhances effect, resulting an improved energy level alignment facilitating transport....
We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 adenocarcinomas and 156 normal tissues from 3 separate cohorts. found that LINC00152 was highly overexpressed tumors as compared their adjacent tissues. Patients with high expression demonstrate a significantly poorer survival than those low expression. verified the diagnostic/prognostic potential of an independent cohort tumor using quantitative RT-PCR. After knockdown siRNAs cell lines, both...
Abstract Prostate cancer (PCa) is one of the leading causes morbidity and mortality in men. Metastasis main cause PCa‐associated death. Recent evidence indicated a significant reduction PCa associated with higher ω‐3 polyunsaturated fatty acids (PUFAs) consumption. However, underlying mechanisms remained elusive. In this study, we applied global acetylome profiling to study effect treatment. Results that oleic acid (OA, monounsaturated acid, MUFA, 100 µM) elevates while EPA (eicosapentaenoic...
This paper aims to create a high-quality surface based on the linear contact material removal mechanism. For this paper, piezo-driven, flexure-based micro-motion stage was developed for vibration-assisted roll-type precision polishing system. Meanwhile, compliance matrix method employed establish amplification ratio and model of flexure The dimensions mechanism were optimized using grey wolves optimization (GWO) algorithm, aiming maximize natural frequencies. Using optimal parameters,...
Background: Our previous studies have identified a serum-based 4-microRNA (4-miRNA) signature that may help distinguish patients with lung cancer (LC) from non-cancer controls (NCs). Here, we used an extended independent cohort of 398 subjects to further validate the diagnostic ability this 4-miRNA signature. Methods: Using quantitative reverse transcription polymerase chain reaction (qRT-PCR), expression 4-miRNAs was assessed in total sera included 213 LC and 185 NCs. A logistic regression...
Abstract Purpose Accumulating evidence has highlighted the critical roles of circular RNAs (circRNAs) in non‐small‐cell lung cancer (NSCLC). This study aims to unveil circRARS (circular RARS) (hsa_circ_0001551) NSCLC. Methods Quantitative real‐time PCR was used determine expression NSCLC tissues and cells. Kaplan–Meier analysis prognostic value expression. CCK8, transwell, wound healing assays were assess proliferation, invasion, migration abilities RNA pull‐down, cell fraction, glucose...