A5073837400- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related Molecular Pathways
- Opioid Use Disorder Treatment
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Lung Cancer Research Studies
- Tracheal and airway disorders
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Vascular Procedures and Complications
- Gastroesophageal reflux and treatments
- Global Cancer Incidence and Screening
- Cancer-related gene regulation
- Aortic aneurysm repair treatments
- Pleural and Pulmonary Diseases
University of Michigan
2017-2025
Michigan Medicine
2020-2024
VA Ann Arbor Healthcare System
2020-2023
Society of Thoracic Surgeons
2022-2023
A. Alfred Taubman Health Care Center
2023
Thoracic Surgery Foundation
2022
American Association for Thoracic Surgery
2022
Ann Arbor VA Medical Center
2021
Urology of Indiana
2017
Ann Arbor Center for Independent Living
2017
Despite advances in the understanding of its molecular pathophysiology, pancreatic cancer remains largely incurable, highlighting need for novel therapies. We developed a chimeric antigen receptor (CAR) specific prostate stem cell (PSCA), glycoprotein that is overexpressed starting at early stages malignant transformation. To optimize CAR design, we used antigen-recognition domains derived from mouse or human antibodies, and intracellular signaling containing one two T costimulatory...
The development of immunotherapy has led to significant progress in the treatment metastatic cancer, including genetic engineering technologies that redirect lymphocytes recognize and target a wide variety tumor antigens. Chimeric antigen receptors (CARs) are hybrid proteins combining antibody recognition domains linked T cell signaling elements. Clinical trials CAR-transduced peripheral blood (PBL) have induced remission both solid organ hematologic malignancies. Chondroitin sulfate...
Tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC) are abnormalities that share a common feature of expiratory narrowing but distinct pathophysiologic entities. Both entities collectively referred to as central (ECAC). The malacia or weakness cartilage supports the tracheobronchial tree may occur only in trachea (ie, tracheomalacia), both bronchi (TBM), (bronchomalacia). On other hand, EDAC refers anterior bowing posterior membrane into lumen with intact cartilage....
Importance Removal of race correction in pulmonary function tests (PFTs) is a priority, given that inappropriately conflates race, social construct, with biological differences and falsely assumes worse lung African American than White individuals. However, the impact decorrecting PFTs for patients cancer unknown. Objectives To identify how many hospitals providing surgery use correction, examine association predicted function, test effect decorrection on surgeons’ treatment recommendations....
Objective: To evaluate demographics and quality metrics across racial ethnic groups amongst patients undergoing lung resection for non-small cell cancer (NSCLC) within the Society of Thoracic Surgeons General Surgery Database (STS GTSD). Summary Background: Studies evaluating disparities NSCLC are limited. Methods: A retrospective cohort analysis STS GTSD was performed between 2015-2022. Multivariable logistic regression operation (wedge versus anatomic resection), operative approach (open...
Abstract Lung cancer (LC) remains the top cause of cancer-associated mortality worldwide, with a 10-year overall survival rate only 5%. While most LCs are smoking related, 25% non-small cell LC (NSCLC) diagnosed in patients little or no history. Fusions involving anaplastic lymphoma kinase (ALK) oncogenic driver ∼3–7% NSCLC. inhibitors targeting domain ALK have proven effective, inevitably, resistance develops limited subsequent efficacious options. We aimed to integrate multiomic...
ABSTRACT Introduction Use of normothermic regional perfusion (NRP) to recover donation after circulatory death (DCD) organs demonstrates increased heart utilization with favorable outcomes. Conversely, DCD lung allograft use when NRP was employed remains controversial. This is a contemporary analysis recipient outcomes in which used. Methods Utilizing the STAR‐OPTN database, all adult recipients United States between January 1, 2020, and June 30, 2024 were identified. defined if time donor...
Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), a chronic inflammatory state that can progress through series of transformative dysplastic states before tumor development. While molecular and genetic changes EAC tumors have been studied, immune microenvironment during progression to remain poorly understood. In this study, we identify potential immunologic occur BE-to-EAC progression. RNA sequencing (RNA-Seq) analysis on tissue samples patients undergoing surgical...
Cryoablation is increasingly being utilized as an alternative to epidurals for patients undergoing thoracotomies. Current evidence suggests cryoablation may decrease postoperative analgesia utilization, but could increase operative times. We hypothesized that the adoption of intraoperative manage post-thoracotomy pain would result in reduced length stay and perioperative compared routine epidural use.
Objective: To describe if patients with chronic opioid use a consistent usual prescriber (UP) prior to surgery and early return that UP (<30 d) would be associated fewer high risk prescribing events in the postoperative period. Summary Background Data: Over 10 million people each year are prescribed opioids for pain. There is little evidence regarding coordination of management best practices on long-term therapy following surgery. Methods: The study design retrospective cohort study. We...
Background: Our previous studies have identified a serum-based 4-microRNA (4-miRNA) signature that may help distinguish patients with lung cancer (LC) from non-cancer controls (NCs). Here, we used an extended independent cohort of 398 subjects to further validate the diagnostic ability this 4-miRNA signature. Methods: Using quantitative reverse transcription polymerase chain reaction (qRT-PCR), expression 4-miRNAs was assessed in total sera included 213 LC and 185 NCs. A logistic regression...