A5034823498- Gene expression and cancer classification
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Statistical Methods and Inference
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Diet and metabolism studies
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Bayesian Methods and Mixture Models
- Advanced Clustering Algorithms Research
- Inflammatory Bowel Disease
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Bayesian Modeling and Causal Inference
- Mycobacterium research and diagnosis
- Genetics, Bioinformatics, and Biomedical Research
Relay Therapeutics (United States)
2025
Global Relay (Canada)
2025
University of Nebraska–Lincoln
2015-2024
Beaumont Hospital
2024
Leibniz Institute of Plant Genetics and Crop Plant Research
2024
Lawrence Livermore National Laboratory
2022
University of Colorado Colorado Springs
2020
University of Washington
2019
University of Miami
2007-2017
Sanofi (United States)
2016
One way to improve both the ecological performance and functionality of probiotic bacteria is by combining them with a prebiotic in form synbiotic. However, degree which such synbiotic formulations strain humans has not been tested systematically. Our goal was use randomized, double-blind, placebo-controlled, parallel-arm clinical trial obese compare physiological impact galactooligosaccharides (GOS) strains Bifidobacterium adolescentis IVS-1 (autochthonous selected via vivo selection)...
Given the powerful implications of relationship quality for health and well-being, a central mission science is explaining why some romantic relationships thrive more than others. This large-scale project used machine learning (i.e., Random Forests) to 1) quantify extent which predictable 2) identify constructs reliably predict quality. Across 43 dyadic longitudinal datasets from 29 laboratories, top relationship-specific predictors were perceived-partner commitment, appreciation, sexual...
The purpose of this study was to develop an integrated genomic-based approach personalized treatment patients with advanced-stage ovarian cancer. We have used gene expression profiles identify likely be resistant primary platinum-based chemotherapy and also alternate targeted therapeutic options for de novo platinum-resistant disease.A model that predicts response therapy developed using a training set 83 serous cancers tested on 36-sample external validation set. In parallel, signatures...
Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation.The objectives this study were the following: 1) to compare transcriptional profiles in APA and adjacent adrenal gland (AAG); 2) test whether gene expression profile clusters with different cell histology; 3) measure frequency determine genotype-phenotype relationship.The design included laboratory analyses 46 unselected APA.The patients had primary...
Breast cancer is the most common in women, and this prevalence has a major impact on health worldwide. Localized breast an excellent prognosis, with 5-year relative survival rate of 85%. However, drops to only 23% for women distant metastases. To date, study metastasis been hampered by lack reliable metastatic models. Here we describe novel vivo model using human xenografts NOD scid gamma (NSG) mice; cells reliably metastasize organs from primary tumors grown within mammary fat pad. This...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor system. Recent work in rodent models ALS has shown that insulin-like growth factor-1 (IGF-1) slows progression when delivered at onset. However, IGF-1's mechanism action along neuromuscular axis remains unclear. In this study, symptomatic mice received IGF-1 through stereotaxic injection an IGF-1-expressing viral vector to deep cerebellar nuclei (DCN), region cerebellum with extensive brain stem and spinal...
Quantitative proteomics analysis of cortical samples 10 Alzheimer's disease (AD) brains versus normally aged was performed by following the accurate mass and time tag (AMT) approach with high resolution LTQ Orbitrap spectrometer. More than 1400 proteins were identified quantitated. A conservative selecting only consensus results four normalization methods suggested used. total 197 shown to be significantly differentially abundant (p-values <0.05, corrected for multiplicity testing) in AD...
Whole grains (WG) and fruits vegetables (FV) have been shown to reduce the risk of metabolic disease, possibly via modulation gut microbiota. The purpose this study was determine impact increasing intake either WG or FV on inflammatory markers microbiota composition.A randomized parallel arm feeding trial completed forty-nine subjects with overweight obesity low intakes WG. Individuals were into three groups (3 servings/d provided): WG, FV, a control (refined grains). Stool blood samples...
Abstract Dramatic improvements in measuring genetic variation across agriculturally relevant populations (genomics) must be matched by identifying and trait such many environments (phenomics). Identifying the most critical opportunities challenges genome to phenome (G2P) research is focus of this paper. Previously (Genome Biol, 23(1):1–11, 2022), we laid out how Agricultural Genome Phenome Initiative (AG2PI) will coordinate activities with USA federal government agencies expand...
Enrichment of adherent-invasive Escherichia coli (AIEC) has been consistently detected in subsets inflammatory bowel disease (IBD) patients. Although some AIEC strains cause colitis animal models, these studies did not systematically compare with non-AIEC strains, and causal links between are still disputed. Specifically, it remains unclear whether shows enhanced pathogenicity compared to that commensal E. found the same ecological microhabitat if vitro phenotypes used classify as...
The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic in patients with gastroesophageal reflux disease, Barrett's esophagus, adenocarcinoma (EAC). However, mechanisms by which microbial communities metabolites contribute reflux-driven EAC remain incompletely understood challenging target. Herein, we utilized a rat reflux-induced model investigate targeting the microbiome-esophageal metabolome axis cranberry...
Abstract Motivation: Global expression patterns within cells are used for purposes ranging from the identification of disease biomarkers to basic understanding cellular processes. Unfortunately, tissue samples in cancer studies usually composed multiple cell types and non-cancerous portions can significantly affect profiles. This severely limits conclusions that be made about specificity gene cell-type interest. However, statistical analysis identify differentially expressed genes related...
Abstract Purpose: Although few women with advanced serous ovarian cancer are cured, detection of the disease at an early stage is associated a much higher likelihood survival. We previously used gene expression array analysis to distinguish subsets cancers based on outcome. In present study, we report early-stage and validate our prognostic model for advanced-stage cancers. Experimental Design: Frozen specimens from 39 I/II, 42 III/IV, 20 low malignant potential were obtained four different...
A recent industry report by Global Relay revealed that 55 per cent of compliance executives consider social media to be an emerging risk. In this paper, Rob Mason explores the four key challenges presents financial services: market risk, marketing and advertising record-keeping risk consumer harm. This paper unpicks regulatory approaches across globe understand how bodies are adjusting existing guardrails acknowledge mitigate risks, as well regulators enforcing new expectations — from rules...
SATB1 has been previously proposed as a key protein that controls the development and progression of breast cancer. We explored potential therapeutic target prognostic marker for human cancer.We used aggressive (MDA-MB-231 BT549) nonaggressive (SKBR3 MCF7) cancer cell lines to investigate target. mRNA expression was silenced in cells by use short hairpin RNAs against SATB1. overexpressed vectors. assessed effect modifying on transformed phenotype examining anchorage-independent...