A5081334626- Esophageal Cancer Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Sulfur Compounds in Biology
- RNA modifications and cancer
- Phytochemicals and Antioxidant Activities
- Gastric Cancer Management and Outcomes
- Oral Health Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Inflammatory mediators and NSAID effects
- Cancer-related Molecular Pathways
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Vitamin C and Antioxidants Research
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury Research
- Lung Cancer Treatments and Mutations
- Garlic and Onion Studies
- Circular RNAs in diseases
- Tannin, Tannase and Anticancer Activities
- Photoacoustic and Ultrasonic Imaging
University of Michigan
2001-2025
Michigan Center for Translational Pathology
2021-2024
State Street (United States)
2024
The Ohio State University
2000-2023
American Association for Thoracic Surgery
2022
Thoracic Surgery Foundation
2022
Fox Chase Cancer Center
2018
Medical College of Wisconsin
2013-2017
Sylvester Comprehensive Cancer Center
2008-2012
University of Miami
2008-2012
The role of circular RNA in cancer is emerging. A newly reported HIPK3 (circHIPK3) critical cell proliferation various types, although its non-small lung (NSCLC), has yet to be elucidated. Our results provided evidence that silencing circHIPK3 significantly impaired proliferation, migration, invasion and induced macroautophagy/autophagy. Mechanistically, we uncovered autophagy was upon loss via the MIR124-3p-STAT3-PRKAA/AMPKa axis STK11 mutant lines (A549 H838). STAT3 abrogation as well...
Lung cancer often has a poor prognosis, with brain metastases major reason for mortality. We modified lonidamine (LND), an antiglycolytic drug limited efficacy, to mitochondria-targeted mito-lonidamine (Mito-LND) which is 100-fold more potent. Mito-LND, tumor-selective inhibitor of oxidative phosphorylation, inhibits mitochondrial bioenergetics in lung cells and mitigates cell viability, growth, progression, metastasis xenografts mice. Mito-LND blocks tumor development by inhibiting...
Abstract This study examined the effects of lyophilized black raspberries (BRB) on azoxymethane (AOM)-induced aberrant crypt foci (ACF), colon tumors, and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in male Fischer 344 rats. AOM was injected (15 mg/kg body wt ip) once per week for 2 wk. At 24 h after final injection, AOM-treated rats began consuming diets containing 0%, 2.5%, 5%, or 10% (wt/wt) BRB. Vehicle controls received 5% BRB diet only. Rats were sacrificed 9 33 wk feeding ACF...
In the present study, we examined ability of dietary freeze-dried strawberries to inhibit N-nitrosomethylbenzylamine (NMBA)-induced tumorigenesis in rat esophagus. Initially, conducted a bioassay determine effects on esophageal tumor development. Two weeks prior NMBA treatment, animals were placed control diet or diets containing 5 and 10% strawberries. treatment was once per week for 15 weeks. At 30 weeks, caused significant reductions multiplicity 24 56%, respectively. Based these results,...
Ellagic acid (EA), a naturally occurring plant polyphenol possesses broad chemoprotective properties. Dietary EA has been shown to reduce the incidence of N-2-fluorenyl acetamide-induced hepatocarcinogenesis in rats and N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumors. In this study changes expression activities specific hepatic mucosal cytochromes P450 (P450) phase II enzymes following dietary treatment were investigated. Liver microsomes cytosol prepared from three groups...
Abstract Abstract: Increased fruit and vegetable consumption is associated with decreased risk of a number cancers epithelial origin, including esophageal cancer. Dietary administration lyophilized black raspberries (LBRs) has significantly inhibited chemically induced oral, esophageal, colon carcinogenesis in animal models. Likewise, berry extracts added to cell cultures cancer-associated processes. Positive results preclinical studies have supported further investigation berries high-risk...
For several years, our laboratory has been evaluating the ability of lyophilized (freeze-dried) black raspberries (Rubus occidentalis, BRBs), blackberries (R. fructicosus, BBs), and strawberries (Fragaria ananasia, STRWs) to inhibit carcinogen-induced cancer in rodent esophagus. To assure "standardized" berry preparations for study, each type is same cultivar, picked at about degree ripeness, washed frozen within 2-4 h time picking, freeze-dried under conditions that preserve components...
Abstract Purpose: The aim of this study was to assess the effects topical application a 10% (w/w) freeze-dried black raspberry (FBR) gel on oral intraepithelial neoplasia (IEN) variables that included histologic diagnoses and loss heterozygosity (LOH) indices. Microsatellite instability and/or LOH at tumor suppressor gene–associated chromosomal loci have been associated with higher risk for IEN progression squamous cell carcinoma. Previously, our laboratories shown FBRs are well tolerated...
Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including vivo models oral, esophageal, colon, breast and skin cancer. Promising results have led to clinical evaluations cancer patients or at increased risk for development.To summarize investigations targeting precancerous lesions with BRB discuss future directions.A thorough literature search was conducted through December 1, 2015 identify all published studies evaluating focused trials.Research investigating...
The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic in patients with gastroesophageal reflux disease, Barrett's esophagus, adenocarcinoma (EAC). However, mechanisms by which microbial communities metabolites contribute reflux-driven EAC remain incompletely understood challenging target. Herein, we utilized a rat reflux-induced model investigate targeting the microbiome-esophageal metabolome axis cranberry...
// Laura A. Kresty 1 , Katherine M. Weh Bree Zeyzus-Johns N. Perez and Amy B. Howell 2 Division of Hematology Oncology, Department Medicine, Medical College Wisconsin, Milwaukee, USA Marucci Center for Blueberry Cranberry Research, Rutgers University, Chatsworth, New Jersey, Correspondence to: Kresty, email: Keywords : autophagy, cranberry proanthocyanidins, esophageal adenocarcinoma, bile acid, PI3K/AKT/mTOR Received July 22, 2015 Accepted August 19, Published September 10, Abstract...
This study was undertaken to evaluate the inhibitory effects of benzyl isothiocyanate (BITC), phenethyl (PEITC), 3-phenylpropyl (PPITC) or 4- phenylbutyl (PBITC) on N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in male Fisher 344 rats. Groups 15 rats were fed modified AIN-76A diet containing four isothiocyanates at concentrations 2.5, 1.0 and 0.4 μmol/g for 25 weeks. After two weeks, administered 0.5 mg/kg NMBA S.C. once weekly Additional controls received only high...
Plant foods and associated nutrients may impact prostate cancer (PC) risk survival. Therefore, we compared dietary intake, mainly plant food groups among 382 controls 478 PC cases (373 incident 105 prevalent cases). Caucasian had significantly higher daily servings of vegetables (3.4 vs. 2.5, P= 0.002) fruits and/or fruit juices (1.6 1.3, P = 0.02) to African American controls. In Caucasians, reported lower intake fiber, vitamin C, A, α -carotene, β cryptoxanthin, folate, genistein,...
The occurrence of esophageal adenocarcinoma and its only recognized precursor lesion, Barrett's esophagus, has rapidly increased during the past three decades. precise reason for rise remains to be elucidated, but increasing rates have been linked multiple nutritional factors. Plant-based diets generally associated with a reduction risk those animal origin escalation. Moreover, number recent in vitro limited vivo investigations reported that cranberry extracts affect cancer-associated...
Abstract Proliferative verrucous leukoplakia (PVL) represents a rare but highly aggressive form of oral with >70% progressing to malignancy. Yet, PVL remains biologically and genetically poorly understood. This study evaluated the cell cycle regulatory genes, p16INK4a p14ARF, for homozygous deletion, loss heterozygosity, mutation events in 20 cases. Deletion exon 1β, 1α, or 2 was detected 40%, 35%, 0% patients, respectively. Deletions exons 1α 1β markedly exceed levels reported...
Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and mortality rates poor survival. Efficacious preventive treatment options are urgently needed. An number of pharmacologic agents targeting cancer cell death via autophagy mechanisms being evaluated in hopes circumventing apoptotic therapeutic resistance. We report for the first time, loss Beclin-1, a key mediator autophagy, was significantly linked to prognostic factors EAC. Specifically, Beclin-1 expression...