A5048308941- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Animal Virus Infections Studies
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Carcinogens and Genotoxicity Assessment
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Polyamine Metabolism and Applications
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Nutrition, Genetics, and Disease
- Computational Drug Discovery Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Cells and Metastasis
National Cancer Institute
2012-2024
National Institutes of Health
2005-2023
Center for Cancer Research
2009-2021
CCS Associates (United States)
2011-2014
Johnson & Johnson (United States)
2014
Center for Medical Technology Policy
2014
Kaiser Permanente Center for Health Research
2014
The University of Texas MD Anderson Cancer Center
2014
Quantum Opus (United States)
2014
University of Michigan–Ann Arbor
2008-2011
Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects nonsteroidal antiinflammatory drugs may be related to their inhibition cyclooxygenase-2.
Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy preventing adenomas with little additional toxicities, suggesting a strategy to improve risk benefit ratios for recurrent adenomas. Three hundred seventy-five patients history resected (> or =3 mm) were randomly assigned receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 once daily matched placebos 36 months, stratified by use low-dose aspirin (81 mg) baseline clinical...
Epidemiological and dietary studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer, possibly through a mechanism involving inhibition cyclooxygenase (COX)-2, which is overexpressed in premalignant adenomatous polyps cancer. Because ultraviolet light (UV) can induce COX-2 nonspecific NSAIDs decrease UV-induced skin we evaluated ability two compounds, celecoxib (a specific inhibitor) indomethacin NSAID), to block tumor development SKH:HR-1-hrBr...
The Lung Master Protocol (Lung-MAP, S1400) is a groundbreaking clinical trial designed to advance the efficient development of targeted therapies for squamous cell carcinoma (SCC) lung. There are no approved specific advanced lung SCC, although Cancer Genome Atlas project and similar studies have detected significant number somatic gene mutations/amplifications in some which targetable by investigational agents. However, frequency these changes low (5%-20%), making recruitment study conduct...
We assessed the effects of 78 potential chemopreventive agents in F344 rat using two assays which inhibition carcinogen-induced aberrant crypt foci (ACF) colon was measure efficacy. In both ACF were induced by carcinogen azoxymethane (AOM) rats sequential weekly injections at a dose 15 mg/kg. Two weeks after last AOM injection, animals evaluated for number crypts detected methylene blue stained whole mounts colon. initiation phase protocol given during period administration, whereas...
Curcumin and quercetin were evaluated in rats for their ability to modulate the carcinogenic activity of azoxy-methane (AOM) colon 7, 12-dimethyl-benz[a]anthracene (DMBA) mammary gland. In AOM-induced cancer model, male Fischer 344 at 8 weeks age started receive either curcumin (8 16g/kg) or (16.8 33.6g/kg) diet 1 week later, administered AOM (30 mg/kg body wt.) by subcutaneous injection.The animals continued two agents until sacrificed 45 later. mediated a dose-dependent inhibition...
Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a fundamental role in chemoprevention carcinogenesis and differentiation therapy. Physiological retinoic acid is obtained through two oxidation steps from dietary retinol, i.e. retinol-->retinal-->retinoic acid. The latter retinal-->retinoic step irreversible eventually marks disposal this nutrient, cytochrome P450-dependent oxidative steps. Mutant mice deficient aryl hydrocarbon receptor (AHR)...