A5074899903- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Metabolism, Diabetes, and Cancer
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- S100 Proteins and Annexins
- Esophageal and GI Pathology
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Cancer Research and Treatments
- Polyamine Metabolism and Applications
- Microscopic Colitis
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- Clostridium difficile and Clostridium perfringens research
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Cancer Risks and Factors
University of California, Irvine
2009-2024
University of California, Irvine Medical Center
2006-2023
Texas Digestive Disease Consultants
2020
Engineering Associates (United States)
2018
Stanford University
2015
UC Irvine Health
2009-2014
Stanford Medicine
2013
Colorado Association of School Executives
2010
Anaheim University
2009
University of Michigan
2007-2008
Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy preventing adenomas with little additional toxicities, suggesting a strategy to improve risk benefit ratios for recurrent adenomas. Three hundred seventy-five patients history resected (> or =3 mm) were randomly assigned receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 once daily matched placebos 36 months, stratified by use low-dose aspirin (81 mg) baseline clinical...
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Obesity is associated with risk of colorectal adenoma (CRA) and cancer. The signaling pathway activated by metformin (LKB1/AMPK/mTOR) implicated in tumor suppression ApcMin/+ mice via metformin-induced reduction polyp burden, increased ratio pAMPK/AMPK, decreased pmTOR/mTOR ratio, pS6Ser235/S6Ser235 polyps. We hypothesized that would affect tissue S6Ser235 among obese patients recent history CRA. A phase IIa clinical biomarker trial was conducted the U.S. National Cancer...
After potentially curative treatment, colorectal cancer (CRC) patients remain at high risk for recurrence, second primary CRC, and high-risk adenomas. In combination with existing data, our previous findings provide a rationale reducing tissue polyamines as tertiary prevention in non-metastatic CRC patients. The goal of this study was to demonstrate rectal polyamine reduction optimally treated stage I-III after intervention daily oral aspirin + dietary arginine restriction. A...
Wireless capsule endoscopy is an important tool for minimally invasive evaluation of the small bowel, allowing improved diagnostic yield with low complication rates relative to traditional modalities. Recently however, reports on bowel perforation after wireless have surfaced. Here we present first case acute in a middle-aged male United States. A 58-year-old presumed quiescent history Crohn's Disease presented Emergency Department septic state 48 hours procedure complaining abdominal pain,...
Abstract Background: Despite advances in colorectal cancer (CRC) screening, early detection, and treatment, CRC remains the 2nd most common cause of death U.S.. Obesity is increasing incidence U.S., has been implicated adenoma (CRA) risk, risk CRA recurrence, CRC. Obese patients with history are a high-risk group that may benefit from novel prevention strategies. There evidence for reduced mortality among metformin users. The signaling pathway activated by (LKB1/AMPK/mTOR) tumor suppression...
The article deals with a number of thyroid abnormalities which produce similar sonographic patterns, characterised by paucity echos low amplitude. It concerns three more or less circumscribed changes (differentiated carcinoma the thyroid, autonomous adenoma and focal thyroiditis) two diffuse conditions (sub-acute lymphocytic thyroiditis, hyperthyroidism). Carcinoma is particular interest. distinguishing features differential diagnosis are discussed.
Introduction: The detection and removal of pre-cancerous polyps via colonoscopy is widely recognized gold standard for the prevention colon cancer. Endocuff® (Arc medical Design Ltd) a recently developed device comprised cap with several soft plastic projections designed to flatten out colonic folds on withdrawal optimize polyp detection. Several studies have evaluated role Endocuff -assisted colonoscopies compared conventional variable results. goal this meta-analysis define extent which...
Long-term use of a proton pump inhibitor (PPI) is known to be associated with fundic gland polyps (FGPs), which can found in up 1.9% the general population. Located primarily body and fundus, these benign gastric mucosal lesions are usually asymptomatic. We describe unique case massive polyposis leading iron-deficiency anemia. A 77-year-old female long-standing history heartburn dyspepsia was referred for Her chronic had been well controlled on daily PPI (rabeprazole) over last 13 years. CT...
A 68-year old Korean male with a history of diabetes mellitus, dyslipidemia, latent TB status post treatment, and prior hepatitis B exposure was diagnosed Crohn's colitis in 2010. He treated multiple agents, including but not limited to anti-TNF rotating antibiotics, topical mesalamine. Anti-TNF therapies appeared be associated leukopenia other complications hence needed discontinued. The patient clinical remission had low fecal calprotectin level while on low-dose suppressive ciprofloxacin...