A5079107815- Platelet Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastroesophageal reflux and treatments
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Structural Behavior of Reinforced Concrete
- Eosinophilic Esophagitis
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Receptor Mechanisms and Signaling
- Esophageal and GI Pathology
- Blood groups and transfusion
- Neural dynamics and brain function
- Structural Engineering and Vibration Analysis
- Neuroscience and Neural Engineering
- Esophageal Cancer Research and Treatment
- Advanced Memory and Neural Computing
- Concrete Corrosion and Durability
- Blood disorders and treatments
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
University of North Carolina at Chapel Hill
2015-2024
University of California, Irvine
2011-2024
University of California, San Diego
2024
Hackensack University Medical Center
2024
VA Long Beach Healthcare System
2011-2023
Institute of Molecular Biology and Biophysics
2022
University of Kansas
2021
University of California, Irvine Medical Center
2014-2020
Tibor Rubin VA Medical Center
2020
Queensland University of Technology
2018
Platelet responses have been associated with end-organ injury and mortality following complex insults such as cardiac surgery, but how platelets contribute to these pathologies remains unclear. Our studies originated from the observation of microvascular platelet retention in a rat surgery model. Ensuing work supported proximity aggregates perivascular mast cells (MCs) demonstrated that activation triggered systemic MC activation. We then identified activating factor (PAF) platelet-derived...
Importance The Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) randomized clinical trial sought to recruit 50 000 adults into a study comparing colorectal cancer (CRC) mortality outcomes after randomization either an annual fecal immunochemical test (FIT) or colonoscopy. Objective To (1) describe participant characteristics and (2) examine who declined participation because of preference for colonoscopy stool testing (ie, occult blood...
AimsMacrophage apoptosis plays a determinant role in progression of atherosclerotic lesions. An important goal atherosclerosis research is to identify new components macrophage that can eventually be exploited as molecular targets strategies aimed at manipulating function the lesion. In previous work from our laboratory, we have shown transient receptor potential canonical 3 (TRPC3) channel an obligatory component survival mechanisms human and murine macrophages TRPC3-deficient non-polarized...
Noncompressible torso hemorrhage accounts for a significant portion of preventable trauma deaths. We report here on the development injectable, targeted supramolecular nanotherapeutics based peptide amphiphile (PA) molecules that are designed to target tissue factor (TF) and, therefore, selectively localize sites injury slow hemorrhage. Eight TF-targeting sequences were identified, synthesized into PA molecules, coassembled with nontargeted backbone at various weight percentages, and...
Recent observations in endothelial cells and macrophages indicate that nicotinic acetylcholine receptors (nAChRs) are potential novel players mechanisms linked to atherogenesis. In macrophages, α7nAChR mediates anti-inflammatory actions contributes regulation of cholesterol flux phagocytosis. Considering macrophage apoptosis is a key process throughout all stages atherosclerotic lesion development, the present study, we examined for first time impact expression function survival using vitro...
The majority of studies on the electrical properties neurons are carried out in rodents, and particular mice. However, minute size this animal compared with humans potentially limits relevance resulting insights. To be able to extrapolate results obtained a small such as rodent, one needs have proper knowledge rules governing how scale animal. Generally speaking, resistances increase cell decreases, thus maintenance equal depolarization across cells different sizes requires underlying...
Diabetes mellitus is associated with an increased risk for cardiovascular disease, but the link between hyperglycemia and atherothrombotic disease not completely understood. Patients diabetes often show hyporesponsiveness to antiplatelet therapies, it has been suggested that hyperreactive reticulated platelets underlie this altered therapeutic response. In issue of JCI, Kraakman et al. uncover a previously unknown enhanced platelet production reactivity. The authors demonstrate high blood...
Abstract Microvascular thrombosis in patients with thrombotic thrombocytopenic purpura (TTP) is initiated by GPIbα-mediated platelet binding to von Willebrand factor (VWF). Binding of VWF GPIbα causes activation the surface integrin αIIbβ3. However, mechanism GPIbα-initiated αIIbβ3 and its clinical importance for microvascular remain elusive. Deletion C-type lectin-like receptor 2 (CLEC-2) did not prevent platelets but specifically inhibited aggregation induced mice. CLEC-2 also GPIbα. Using...
Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), which has emerged as a potent molecular therapy in the treatment B-cell malignancies, and continues to be investigated for variety blood cancers. Despite excellent safety profile high tolerability
Motoneurons have been shown to exhibit both bistable firing and synaptic amplification. Both of these behaviors generally attributed a single mechanism-dendritic plateau potentials based on L-type Ca(2+) conductances. However, our recent discovery fast-amplification mode calls this into question. Here we examine the possibility that two mechanisms underlie behaviors, one being slow-mode bistability mechanism (i.e., Ca(2+)-conductance-based dendritic plateaus) other theoretical fast-mode...
Platelets are important for the development and progression of atherosclerotic lesions. However, relatively little is known about contribution platelet signaling to this pathological process. Our recent work identified 2 independent, yet synergistic, pathways that lead activation small GTPase Rap1; one mediated by guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), other P2Y12, a receptor adenosine diphosphate target antiplatelet drugs. In study, we evaluated lesion formation in...
Platelet transfusions can fail to prevent bleeding in patients with inherited platelet function disorders (IPDs), such as Glanzmann's thrombasthenia (GT; integrin αIIbβ3 dysfunction), Bernard-Soulier syndrome [BSS; glycoprotein (GP) Ib/V/IX dysfunction], and the more recently identified nonsyndromic RASGRP2 variants. Here, we used IPD mouse models real-time imaging of hemostatic plug formation investigate whether dysfunctional platelets impair healthy donor [wild-type (WT)] platelets. In...