A5066577343- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Medical Research and Treatments
- Liver physiology and pathology
- Gastrointestinal Tumor Research and Treatment
- Multiple and Secondary Primary Cancers
- Land Use and Ecosystem Services
- Glycosylation and Glycoproteins Research
- Soft tissue tumor case studies
- COVID-19 diagnosis using AI
- Artificial Intelligence in Healthcare and Education
University of California, Irvine
2014-2023
University of California, Irvine Medical Center
2016-2022
Docbot (United States)
2019-2021
Kaiser Permanente Anaheim Medical Center
2019
University of Missouri Health System
2016
VA Long Beach Healthcare System
2016
UC Irvine Health
2014
Mayo Clinic
1995-2003
Mayo Clinic in Arizona
1998
Rockefeller University
1995
Helicobacter pylori is associated with an inflammatory reaction in the stomach and duodenum, yet mechanism of this infiltrate unknown. The ability to secrete a factor that attracts leucocytes investigated. conditioned supernatant attracted neutrophils monocytes 50-100% activity control chemotactic factor, 10(-8) M formyl-methionine-leucine-phenylalanine. Strains derived from individuals ulcer or non-ulcer H infections displayed similar activity. Preliminary characterisation shows has...
OBJECTIVES: Reliable in situ diagnosis of diminutive (≤5 mm) colorectal polyps could allow for “resect and discard” “diagnose leave” strategies, resulting $1 billion cost savings per year the United States alone. Current methodologies have failed to consistently meet Preservation Incorporation Valuable endoscopic Innovations (PIVIs) initiative thresholds. Convolutional neural networks (CNNs) potential predict polyp pathology achieve PIVI thresholds real time. METHODS: We developed a...
Artificial intelligence (AI) is rapidly integrating into modern technology and clinical practice. Although in its nascency, AI has become a hot topic of investigation for applications Multiple fields medicine have embraced the possibility future with assisting diagnosis pathology applications.In field gastroenterology, been studied as tool to assist risk stratification, diagnosis, pathologic identification. Specifically, great interest endoscopy substantial potential revolutionize practice...
BACKGROUND : Artificial intelligence (AI) research in colonoscopy is progressing rapidly but widespread clinical implementation not yet a reality. We aimed to identify the top priorities. METHODS An established modified Delphi approach for priority setting was used. Fifteen international experts, including endoscopists and translational computer scientists/engineers, from nine countries participated an online survey over 9 months. Questions related AI were generated as long-list first round,...
Colorectal cancer is the second most deadly and third common in world. Its development heterogenous, with multiple mechanisms of carcinogenesis. Two distinct include adenoma-carcinoma sequence serrated pathway. The gut microbiome has been identified as a key player sequence, but its role carcinogenesis less clear. In this study, we characterized 140 polyp-free polyp-bearing individuals using colon mucosa fecal samples to determine if composition was associated each two pathways. We...
Studying primary cultures of replicating canine oxyntic mucosal cells, we found evidence for modulation cell growth by endogenous factors. [3H]thymidine incorporation into DNA was rapid with cells cultured in medium free serum or added factors, and rates these were markedly dependent on plating density, indicating mitogenic control soluble Data indicated that transforming factor-alpha (TGF-alpha) exerted under the following conditions. 1) TGF-alpha detected radioimmunoassay...
Pirfenidone (Deskar, Marnac Inc., Dallas, TX), 5-methyl-1-phenyl-2-(1H)-pyridone, is a broad-spectrum, noncytotoxic, oral antifibrotic agent that reported to inhibit or block the action of cytokine growth factors: transforming factor beta1, platelet-derived factor, epidermal and fibroblast prevent formation new fibrotic lesions.We enrolled 10 women four men with extensive familial adenomatous polyposis (FAP)-associated desmoid disease in 2-yr open-label treatment trial pirfenidone. Imaging...
Level of autoantibodies after autologous hematopoietic stem cell transplantation. AGA, antigliadin antibody; AHSCT, transplantation; Anti-GAD65, Ab anti-glutamic acid decarboxylase epitope 65 Anti-TPO, anti-thyroid peroxidase CU, chemiluminescent unit.
Introduction: For every percentage increase in adenoma detection rate (ADR), risk of interval colorectal cancer is reduced by 3%. Adenoma prevalence estimated to be 50%. Ideally, ADR should reflect prevalence, yet varies between 5 and 55% among colonoscopist. We hypothesize that computer-assisted polyp identification could help bring low ADRs closer true reduce incidence. Methods: Utilizing our colonoscopy quality database (Qulaoscopy, Docbot, Inc,), we applied the VGG-16 model as starting...
Introduction: Adenoma detection rate (ADR) is inversely related to risk of subsequent colorectal cancer. Unfortunately, colonoscopists vary widely in their rates adenomas (ADR). Endocuff, a cap device with flexible finger-like projections that assists viewing behind folds, associated higher ADRs. New devices including AmplifEYE (AC) and second generation Endocuff Vision (EC) have not been rigorously compared conventional colonoscopy (CC) for ADR. Methods: This retrospective nonrandomized...