A5046936825- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Biliary and Gastrointestinal Fistulas
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Tuberculosis Research and Epidemiology
- Diversity and Career in Medicine
- Renewable Energy and Sustainability
- Leprosy Research and Treatment
- EU Law and Policy Analysis
- Diverticular Disease and Complications
- Dysphagia Assessment and Management
- Autoimmune and Inflammatory Disorders
Harvard University
2022-2024
Beth Israel Deaconess Medical Center
2021-2024
Albert Einstein College of Medicine
2023
Montefiore Medical Center
2023
University of California, Irvine
2018-2021
University of California, Irvine Medical Center
2019-2021
Rockefeller University
2011-2012
Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines elicit such would be protective. Thus far, however, few occur naturally have been characterized. To determine whether these are part a larger group related molecules, we cloned 576 new from four unrelated individuals. All individuals produced expanded clones potent CD4-binding-site mimic binding to CD4. Despite extensive hypermutation, the shared consensus sequence 68 immunoglobulin H...
Structural analysis of an HIV antibody reveals residues important for neutralization breadth and potency.
Artificial intelligence (AI) is rapidly integrating into modern technology and clinical practice. Although in its nascency, AI has become a hot topic of investigation for applications Multiple fields medicine have embraced the possibility future with assisting diagnosis pathology applications.In field gastroenterology, been studied as tool to assist risk stratification, diagnosis, pathologic identification. Specifically, great interest endoscopy substantial potential revolutionize practice...
Intestinal tuberculosis (ITB) and Crohn’s disease (CD) very closely resemble each other in symptomatology, imaging, appearance, pathology. While ITB is rare the United States, its prevalence significantly higher endemic areas, thus presenting a diagnostic dilemma immigrant populations from high-risk countries. This patient was diagnosed with CD treated anti-TNF agents after indeterminate screening for latent tuberculosis. He then admitted septic shock intestinal perforation due to...
Introduction: Mucosal healing is a primary goal of treatment in ulcerative colitis (UC) and universal endpoint therapeutic trials. Endoscopic assessment mucosal healing, however, highly subjective with disagreement among experts using standardized scoring systems. The most commonly used scale the Mayo Subscore (MES). We hypothesized that convolutional neural network (CNN) could provide novel means to UC endoscopic score reproducible, unambiguous operator-independent. Methods: 9,538 images...
Patients with infl ammatory bowel disease who are taking monoclonal antibodies against tumor necrosis factor alpha (TNF), interleukins 12 and 23, or integrin can continue them around the time of surgery, but small-molecule drugs such as tofacitinib should be withheld.Infl encompasses Crohn ulcerative colitis, biologic now play an integral role in treatment both.Biologic therapy is supplanting thiopurines main for disease, leading to debate regarding how these managed preoperatively patients...
https://www.videogie.org/cms/asset/c88d1940-2c11-46c7-bea4-5c3b1cb6a0d9/mmc1.mp4Loading ... Download .mp4 (73.53 MB) Help with files Video 1This video is our description of use the novel dynamic rigidizing overtube in a challenging colonoscopy case which looping was causing significant bradycardia and inability to advance colonoscope cecum. The overtube, through sequential cycles its flexible rigidized state, allowed for easy movement
Introduction: Williams syndrome, first described in 1961 by J.C.P Williams, is an autosomal dominant disease caused a hemizygous deletion on chromosome 7q11.23. This with estimated prevalence of 1:7,500 to 1:20,000, characterized distinctive facies, developmental delay, connective tissue abnormalities and involves multiple systems including cardiovascular, endocrine gastrointestinal. Commonly gastrointestinal features include feeding difficulties children (70%), constipation (50%), umbilical...
Introduction: Granulomatosis as a foreign body reaction has been described in the setting of prosthesis placement, cosmetic procedures, retained surgical debris, and injection drug use. Most commonly, granulomas involve skin soft tissues but may also affect lung, liver, arachnoid membrane or occur systemic granulomatous with multi-organ involvement. Additives such talc have implicated cause. Case Description/Methods: The patient is 46 year-old woman who initially presented worsening nausea,...
Most post-cholecystectomy biliary strictures can be treated endoscopically as long stenting is possible. We describe a successful EUS-guided antegrade approach to treatment of benign stricture, which could not stented conventionally due an acute angle alpha loop deformity the bile duct. A 70 year-old woman with history laparoscopic cholecystectomy one year ago presented another hospital obstruction and cholangitis. She reported complicated course after surgery percutaneous drainage leak for...
INTRODUCTION: Peroral endoscopic myotomy (POEM) is a promising novel treatment modality for achalasia. Treatment success usually determined by the patient's improvement in symptoms. A diagnostic tool during POEM to evaluate effectiveness of may aid performing procedure optimally. One such Endoluminal Functional Lumen Imaging Probe (FLIP), which uses impedance planimetry real-time, intraoperative measurement gastroesophageal junction diameter, compliance, distension, and surface area. Here we...
INTRODUCTION: Ethnic and racial disparities in colorectal cancer (CRC) incidence mortality rate have been well studied the literature. However, no study to date has compared surrogates of precancerous polyp prevalence: adenoma detection (ADR), (PDR), sessile serrated (SDR) amongst ethnic groups with respect location. This serves compare ethnicities ADR, PDR, SDR 3 as a function anatomic METHODS: retrospective nonrandomized nonblinded cohort utilized prospectively collected data at our single...
INTRODUCTION: Achalasia is a primary motility disorder characterized by aperistalsis and failure of lower esophageal sphincter relaxation. Traditionally, treatment modalities have consisted drug therapy, botulinum toxin injections, laparoscopic Heller myotomy, balloon pneumatic dilatation. However, in the past several years, novel technique peroral endoscopic myotomy (POEM) has gained popularity, as prior studies suggested that it offers excellent short-term outcomes. In this study, we...
INTRODUCTION: A 66-year-old woman with a history of Roux-en-Y gastric bypass, thromboembolic CVA on dual antiplatelet therapy, and known common bile duct (CBD) stones presented an outside facility 2 months prior complaining chronic intermittent abdominal pain jaundice. She was in sepsis due to cholangitis MRCP showed 2.1 cm CBD stone. ERCP unsuccessful her altered anatomy; therefore, she treated medically referred for repeat attempt at ERCP, lithotripsy clearance. CASE DESCRIPTION/METHODS:...
INTRODUCTION: Acquired megacolon is a rarely diagnosed condition that may be source of significant distress in the acutely hospitalized patient. It presents either gender at any age. Symptoms, when present, are typically abdominal pain with distention, gas distress, and constipation. Reported cases less than 10 cm on diagnostic imaging. Pathology findings vary greatly include muscularis hypertrophy or degeneration smooth muscle, damaged reduced ganglia, melanosis coli, chronic inflammation....