A5002103444- Cancer, Hypoxia, and Metabolism
- Electron Spin Resonance Studies
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Redox biology and oxidative stress
- Lanthanide and Transition Metal Complexes
- Magnolia and Illicium research
- Molecular Sensors and Ion Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Supramolecular Chemistry and Complexes
- Magnetism in coordination complexes
- Metabolomics and Mass Spectrometry Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sulfur Compounds in Biology
- ATP Synthase and ATPases Research
- PI3K/AKT/mTOR signaling in cancer
- Free Radicals and Antioxidants
- Immune Cell Function and Interaction
- Oxidative Organic Chemistry Reactions
- Eicosanoids and Hypertension Pharmacology
Centre National de la Recherche Scientifique
2016-2025
Aix-Marseille Université
2016-2025
Institut de Chimie Radicalaire
2013-2023
Université Sorbonne Paris Nord
2021
Medical College of Wisconsin
2007-2018
Cegep de Saint Jerome
2014
Boronates, a group of organic compounds, are emerging as one the most effective probes for detecting and quantifying peroxynitrite, hypochlorous acid, hydrogen peroxide. Boronates react with peroxynitrite nearly million times faster than Boronate-containing fluorogenic compounds have been used to monitor real time generation in cells imaging peroxide living animals. This perspective highlights potential applications boronates other fluorescent high-throughput analyses hydroperoxides...
Lung cancer often has a poor prognosis, with brain metastases major reason for mortality. We modified lonidamine (LND), an antiglycolytic drug limited efficacy, to mitochondria-targeted mito-lonidamine (Mito-LND) which is 100-fold more potent. Mito-LND, tumor-selective inhibitor of oxidative phosphorylation, inhibits mitochondrial bioenergetics in lung cells and mitigates cell viability, growth, progression, metastasis xenografts mice. Mito-LND blocks tumor development by inhibiting...
Abstract Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in cancer treatment based on recent evidence of its apparent chemopreventive properties. Met weakly cationic and targets the mitochondria to induce cytotoxic effects tumor cells, albeit not very effectively. We hypothesized that increasing mitochondria-targeting potential by attaching a positively charged lipophilic substituent would enhance antitumor activity Met. In pursuit this question, we...
Herein we describe a high-throughput fluorescence and HPLC-based methodology for global profiling of reactive oxygen nitrogen species (ROS/RNS) in biological systems. The combined use HPLC detection is key to successful implementation validation this methodology. Included here are methods specifically detect quantitate the products formed from interaction between ROS/RNS fluorogenic probes, as follows: superoxide using hydroethidine, peroxynitrite boronate-based nitric oxide-derived...
We describe a photochemical method to introduce single alcohol function directly on cucurbit[n]urils (n = 5, 6, 7, 8) with conversions of the order 95-100% using hydrogen peroxide and UV light. The reaction was easily scaled up 1 g for CB[6] CB[7]. Spin trapping cucurbituril radicals combined MS experiments allowed us get insights about mechanism characterize CB[5], CB[6], CB[7], CB[8] monofunctional compounds. Experiments involving (18)O isotopically labeled water indicated that complex...
Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library bioactive compounds. By using multiple probes (hydroethidine, hydropropidine, Amplex Red, coumarin boronate) with well defined redox chemistry that form highly diagnostic marker products upon reaction (O2̇̄), peroxide (H2O2), peroxynitrite (ONOO−), number false positives was greatly decreased. Selected hits Nox2...
Abstract Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased accumulation and antitumor activity in vitro. Using situ vaccination approach, local injection of into primary tumors triggered potent T cell immune responses locally distant tumor sites. Mitochondria‐targeted treatment led significant reductions both granulocytic myeloid‐derived suppressor cells regulatory the...
Here we report the coupling of a cyclic peptide (VH4127) targeting low density lipoprotein (LDL) receptor (LDLR)
Radiation therapy (RT) is the cornerstone treatment for prostate cancer; however, it frequently induces gastrointestinal and genitourinary toxicities that substantially diminish patients' quality of life. While many individuals experience transient side effects, a subset endures persistent, long-term complications. A promising strategy to mitigate these involves enhancing tumor radiosensitivity, potentially allowing lower radiation doses. In this context, mito-lonidamine (Mito-LND), an...