A5023193693- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Synthesis of Indole Derivatives
- Natural Compound Pharmacology Studies
- Chromatography in Natural Products
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Biological Research and Disease Studies
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- interferon and immune responses
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- Telomeres, Telomerase, and Senescence
- Corneal Surgery and Treatments
- Microtubule and mitosis dynamics
University of Michigan
2024-2025
Yonsei University
2019-2022
National Cancer Center
2022
Gyeongsang National University
2016-2020
Abstract Programmed death‐ligand 1 (PD‐L1) is a major target to cancer immunotherapy, and anti‐PD‐L1 anti‐PD‐1 antibody‐mediated immunotherapy are being increasingly used. However, immune checkpoint inhibitors (ICIs) ineffective in treating large tumors cause various immune‐related adverse events nontarget organs, including life‐threatening cardiotoxicity. Therefore, the development of new therapeutic strategies overcome these limitations crucial. The focus this study forkhead box protein M1...
Abstract Lung cancer (LC) remains the top cause of cancer-associated mortality worldwide, with a 10-year overall survival rate only 5%. While most LCs are smoking related, 25% non-small cell LC (NSCLC) diagnosed in patients little or no history. Fusions involving anaplastic lymphoma kinase (ALK) oncogenic driver ∼3–7% NSCLC. inhibitors targeting domain ALK have proven effective, inevitably, resistance develops limited subsequent efficacious options. We aimed to integrate multiomic...
Abstract Melanogenesis is a key pathway for the regulation of skin pigmentation and development skin‐lightening/skin‐whitening drugs or cosmetics. In this study, we found that β‐mangostin from seedcases Garcinia mangostana inhibited α‐melanocyte‐stimulating hormone (α‐ MSH )‐mediated melanogenesis in B16F10 melanoma cells three‐dimensional human model. β‐Mangostin significantly protein level tyrosinase induced by α‐ UPS (ubiquitin proteasome system)‐independent lysosome‐dependent manner. The...
Abstract Cystatin SN (CST1), a known inhibitor of cathepsin B (CatB), has important roles in tumor development. Paradoxically, CatB is member the cysteine family that acts cellular processes, such as development and invasion. However, relationship between CST1 CatB, their are poorly understood. In this study, we observed knockdown induced activity senescence-associated β -galactosidase, marker senescence, expression secretory phenotype genes, including interleukin-6 chemokine (C-C motif)...
Tumor cell resistance to anti-cancer drugs is a major obstacle in tumor therapy. In this study, we investigated the mechanism of cordycepin-mediated resensitization cisplatin T24R2 cells, T24-derived line. Treatment with cordycepin or (2 μg/mL) alone failed induce death but combination treatment these significantly induced apoptosis through mitochondrial pathways, including depolarization membranes, decrease anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, increase pro-apoptotic Bak Bax....
Although family with sequence similarity 188 member B (FAM188B) is known to be a of novel putative deubiquitinase family, its biological role has not been fully elucidated. Here, we demonstrate the oncogenic function FAM188B via regulation forkhead box M1 (FOXM1), another transcription factor, in lung cancer cells. knockdown induced inhibition cell growth along downregulation mRNA and protein levels FOXM1. also resulted Survivin cycle-related proteins, which are direct targets Interestingly,...
Long-non coding RNAs (LncRNAs) constitute a wide and extremely diverse family of RNA transcripts that are greater than 200 base pairs in length not translated into proteins. X-inactive specific transcript (XIST) was the first long non-coding to be discovered, back 1991. Its function X-chromosome inactivation has been extensively studied for three decades, though other functional roles XIST involve variety fascinating mechanisms remain elucidated. Here, we review emerging oncogenic role...
Abstract Background: The therapeutic landscape for chromosomally rearranged anaplastic lymphoma kinase (ALK) has focused on the development of Tyrosine-kinase inhibitors (TKI) that specifically target ALK activity. However, as patients progress first- and second line TKIs, over 50% resistance is due to non-mutational via compensatory pathways, also known ALK-non dominant resistance. Alterations in other drivers such EGFR, KRAS, MET account some mechanisms. Thus, here we explore activity drug...
Abstract Background: Lung cancer (LC) remains the top cause of cancer-associated mortality worldwide, with a 10-year overall survival rate only 5%. While most LCs are smoking related, in US, 25% non-small cell LC (NSCLC) diagnosed patients little or no history. Fusions involving anaplastic lymphoma kinase (ALK) oncogenic driver ~3-7% NSCLC. inhibitors targeting domain ALK (TKIs) have proven extremely effective, inevitably, resistance develops limited effective treatment options....
215 Background: Lung cancer (LC) is the top cause of cancer-associated mortality worldwide, with a 10-year overall survival rate 5%. Although most LCs are smoking related, in US, 25% non-small cell LC (NSCLC) diagnosed persons little or no history. Fusions involving anaplastic lymphoma kinase (ALK) oncogenic driver ~3–7% NSCLC. While inhibitors targeting domain ALK (TKIs) have proven extremely effective, inevitably, resistance develops limited treatment options beyond second line TKIs....
Immunotherapy The FOXM1 inhibitor, thiostrepton, inhibits the expression of programmed death-ligand 1 (PD-L1) on surface cancer cells, allowing cytotoxic T cells to recognize cells. Combination thiostrepton and an immune checkpoint inhibitor significantly improves immunotherapy outcomes in immune-resistant lung tumors. More details can be found article number 2202702 by Yongdoo Choi, Sung-Ho Goh, co-workers.