A5102734693- MicroRNA in disease regulation
- Advanced Radiotherapy Techniques
- Shoulder Injury and Treatment
- Circular RNAs in diseases
- Medical Imaging Techniques and Applications
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Shoulder and Clavicle Injuries
- Marine and Coastal Research
- Glioma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Nerve Injury and Rehabilitation
- Ferroptosis and cancer prognosis
- Renal function and acid-base balance
- Pediatric Urology and Nephrology Studies
- Diverse Approaches in Healthcare and Education Studies
- RNA modifications and cancer
- Renal and Vascular Pathologies
- Breast Cancer Treatment Studies
- Radiation Therapy and Dosimetry
Seoul National University
2017-2023
Korea University
2022-2023
Gachon University Gil Medical Center
2016-2023
National Cancer Center
2020-2022
Korea Institute of Radiological and Medical Sciences
2015-2021
Seoul National University Hospital
2015-2020
Harvard University
2013-2016
Dana-Farber Cancer Institute
2013-2016
Ulsan College
2014-2015
University of Ulsan
2014-2015
High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum poly(ADP-ribose) polymerase inhibitors [PARPis]) due an underlying defect in homologous recombination (HR). However, resistance PARPis represents a significant barrier the long-term survival of these patients. Although BRCA1/2-reversion are clinically validated mechanism, they account for less than half...
Abstract Programmed death‐ligand 1 (PD‐L1) is a major target to cancer immunotherapy, and anti‐PD‐L1 anti‐PD‐1 antibody‐mediated immunotherapy are being increasingly used. However, immune checkpoint inhibitors (ICIs) ineffective in treating large tumors cause various immune‐related adverse events nontarget organs, including life‐threatening cardiotoxicity. Therefore, the development of new therapeutic strategies overcome these limitations crucial. The focus this study forkhead box protein M1...
Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases cell cycle. Initiation HR in G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion cells can lead loss-of-heterozygosity (LOH), which potentially carcinogenic. We conducted a gain-of-function screen identify miRNAs that regulate HR-mediated repair, and these miRNAs, miR-1255b, miR-148b*, miR-193b* specifically suppress HR-pathway phase....
Background: Repair tension of a torn rotator cuff can affect healing after repair. However, measurement the actual during arthroscopic repair is not feasible. The relationship between and remains unclear. Purpose/Hypothesis: purpose this study was to evaluate effect on at site. hypothesis that would be major factor in determining anatomic outcome Study Design: Cohort study; Level evidence, 2. Methods: Arthroscopic repairs (132 patients) for full-thickness tears were analyzed. An...
// Hyun Joo Chung 1, 2 , Young Eun Choi 1 Sook Kim Young-Hoon Han Myung-Jin Park In Hwa Bae Division of Radiation Cancer Research, Korea Institute Radiological & Medical Sciences, Seoul, Research Center for Radio-Senescence, Correspondence to: Bae, e-mail: ihbae@kirams.re.kr Keywords: miR-29b, BCL2L2, tumorigenicity, stemness, GBM Received: March 24, 2015 Accepted: June 09, Published: 19, ABSTRACT Glioblastoma multiforme (GBM) is the most common malignant brain tumor and exhibits aggressive...
// Young Eun Choi 1 , Chiara Battelli 2 Jacqueline Watson Joyce Liu 3 Jennifer Curtis Alexander N. Morse 4 Ursula A. Matulonis Dipanjan Chowdhury Panagiotis Konstantinopoulos 1, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School Maine Center for Medicine, Scarborough, Gynecologic Oncology Program, New York University Global Institute Public Health Correspondence: Konstantinopoulos, email: Keywords : Epithelial ovarian cancer, platinum, PARP inhibitors,...
Triple negative breast cancer (TNBC) has caught the attention of oncologists worldwide because poor prognosis and paucity targeted therapies. Gene pathways have been widely studied, but less is known about epigenetic factors such as microRNAs (miRNAs) their role in tailoring an individual systemic surgical approach for patients. The aim study was to examine selected miRNAs TNBC core biopsies sampled before preoperative chemotherapy subsequent pathologic response mastectomy or conservation...
Radiotherapy induces the production of cytokines, thereby increasing aggressive tumor behavior. This radiation effect results in failure radiotherapy and increases mortality rate patients. We found that interleukin-4 (IL-4) IL-4Rα (IL-4 receptor) are highly expressed various human cancer cells subsequent to treatment. In addition, IL-4 is overexpressed metastatic carcinoma tissues compared with infiltrating tissues. High expression patients strongly correlated poor survival. The this study...
Purpose Stereotactic radiotherapy, which delivers an ablative high radiation dose to a target volume for maximum local tumor control, requires rapid fall-off outside the prevent extensive damage nearby normal tissue. Currently, there is no tool comprehensively evaluate gradient near volume. We propose curve (DGC) as new quality of treatment plan with respect characteristics. Methods The average distance between two isodose surfaces was represented by index (DGI) estimated simple equation...
The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and intrinsic or acquired radioresistance. Therefore, it essential to understand the molecular network responsible for regulating radiosensitivity/resistance. Here, an unbiased functional screen identified four microRNAs (miR1, miR125a, miR150, miR425) that induce Considering clinical importance patients with glioblastoma, impact these miRNAs on glioblastoma radioresistance was investigated. Overexpression...
Background/Aim: To evaluate whether topical use of a film-forming silicone gel (StrataXRT®) could reduce radiation dermatitis compared to moisturizing cream (X-derm®) in patients receiving whole breast radiotherapy. Patients and Methods: A total 56 with cancer were randomized StrataXRT or X-derm. The severity was graded using physiological skin parameters, clinician-assessed visual rating scales patient-reported symptoms. Changes these parameters from baseline 4 weeks post-radiotherapy...
Purpose . Use of tranexamic acid (TXA) in the setting arthroplasty lower extremity has been previously described. The aim this study was to evaluate benefit a single dose TXA (500 mg vial) administered intravenously just prior RTSA an Asian population. Methods records 48 patients (no TXA, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">24</mml:mn></mml:math>, versus...
The disturbance of rotator cuff tendon perfusion has been connected with the suture-bridge configuration repair (SBCR) technique; however, in vivo assessments blood supply have problematic other modalities. An evaluation tissue by an indocyanine green (ICG) fluorescence arthroscope developed to counteract this difficulty.To verify hindrance SBCR, we used ICG camera compare parallel-type transosseous (PTR) and SBCR rabbits immediately at 3 days after repair.Controlled laboratory study.Acute...
We investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) patients with cervical cancer.We conducted a review 40 treated RT. All received external beam RT intracavitary brachytherapy. The were measured pre-RT mid-RT. Overall survival (OS) progression free (PFS) estimated, possible factors for analyzed.The correlation coefficient between reduction rate (pTVRR) all was 0.550 (P <...
Abstract Introduction The present study evaluated the threshold dose for hepatic parenchymal changes on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid ( G d‐ EOB ‐ DTPA )‐enhanced magnetic resonance MR ) images after stereotactic body radiation therapy SBRT hepatocellular carcinoma HCC ). Methods Twenty patients with available data of follow‐up acquired 2–4 months completion were selected among registered patients. was performed using multiple coplanar and non‐coplanar beams...
Breast cancer is the most common female in world. Despite active research on metastatic breast cancer, treatment of patients still difficult because mechanism not well known. Therefore, new targets and mechanisms for diagnosis required. On other hand, microRNA (miRNA) has advantage simultaneously regulating expression many target genes, so it been proposed as an effective biomarker various diseases including cancer. This study analyzed role DBC2 (deleted 2), which known to inhibit its...
Although many surgeons have anecdotally described reversing the polarity of autograft with intent improving regeneration, optimal orientation autogenous nerve graft remains controversial. The aim this study was to compare (1) outcomes orthodromic and antidromic grafts clarify effect (2) outcome either form that repair.In 14 26 rabbits used in study, a 1 cm defect made tibial nerve. An on one side an other were performed using 1.2 long segment peroneal In remaining 12 rabbits, transected...
Abstract Aims To evaluate the efficacy and safety of rivoglitazone, a peroxisome proliferator‐activated receptor γ agonist in thiazolidinedione class, subjects with suboptimally controlled type 2 diabetes mellitus ( T2DM ). Methods Subjects aged ≥18 years haemoglobin A1c HbA1c ) >7.0% ≤8.5%, who were treatment naïve or receiving non‐thiazolidinedione antidiabetes monotherapy, entered 2‐week washout single‐blind placebo run‐in period then randomized : 4 11 to double‐blind placebo,...
Although family with sequence similarity 188 member B (FAM188B) is known to be a of novel putative deubiquitinase family, its biological role has not been fully elucidated. Here, we demonstrate the oncogenic function FAM188B via regulation forkhead box M1 (FOXM1), another transcription factor, in lung cancer cells. knockdown induced inhibition cell growth along downregulation mRNA and protein levels FOXM1. also resulted Survivin cycle-related proteins, which are direct targets Interestingly,...