A5043919045- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Frailty in Older Adults
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Endometrial and Cervical Cancer Treatments
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Cancer survivorship and care
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Urinary and Genital Oncology Studies
- GDF15 and Related Biomarkers
- Colorectal and Anal Carcinomas
Gachon University
2008-2024
Gachon University Gil Medical Center
2015-2024
Deleted Institution
2010-2016
Samsung Medical Center
2012-2013
Sungkyunkwan University
2012-2013
Background Sarcopenia, defined as decreased skeletal muscle mass, is prevalent and associated with poor prognosis in various solid tumors. This study aimed to determine the prognostic role of sarcopenia patients advanced gastric cancer (AGC). Methods retrospective consisted 140 consecutive who underwent palliative chemotherapy for AGC. A cross-sectional area at level third lumbar vertebra (L3) was measured using baseline computed tomography (CT) scans. Sarcopenia a L3 index ≤ 49 cm2/m2 men...
Background The prognostic significance of sarcopenia, an important component cancer cachexia, has been demonstrated in oncologic patients. Catabolic drivers have suggested to be key features cachexia. Objective To determine the relationship between systemic inflammatory markers and CT-determined muscle mass patients with SCLC. Methods Cross-sectional areas were evaluated at level third lumbar vertebra (L3) using baseline CT images 186 SCLC Sarcopenia was defined as a L3 index (L3MI, area...
We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well their subsequent overall median survival following diagnosis, considering epidermal growth factor receptor (EGFR) mutational status.We retrospectively medical records of 259 diagnosed advanced NSCLC from January 2010 August 2013, who were tested EGFR mutations. The diagnosis development BM and after (BM-OS) evaluated compared by status.Sixty-seven (25.9%)...
Skeletal muscle depletion is an important prognostic factor in patients with chronic obstructive pulmonary disease (COPD); a recent study demonstrated significant correlations between pectoralis area on axial CT image and COPD-related traits. The purpose of this was to evaluate the relation areas scans total body skeletal mass (SMM) healthy subjects.For 434 subjects that underwent low-dose chest bioelectrical impedance analysis (BIA) during health screening from January June 2014,...
Purpose The aim of this study was to verify prognostic factors including sarcopenia in patients with recurrent or metastatic pancreatic cancer receiving gemcitabine-based chemotherapy. Materials and Methods Medical records computed tomography scan consecutive treated palliative chemotherapy from 2008 2014 were reviewed. lumbar skeletal muscle index at third spine level computed, together clinicolaboratory factors, univariate multivariable analyses for overall survival (OS) performed. Results...
Background Advanced lung cancer inflammation index (ALI, body mass [BMI] x serum albumin/neutrophil-lymphocyte ratio [NLR]) has been shown to predict overall survival (OS) in small cell (SCLC). CT enables skeletal muscle be quantified, whereas BMI cannot accurately reflect composition. The purpose was evaluate prognostic value of modified ALI (mALI) using CT-determined L3 (L3MI, area at L3/height2) beyond original ALI. Methods L3MIs were calculated the images 186 consecutive patients with...
Backgrounds/Aims . Watson for Oncology (WFO) is a cognitive technology that processes medical information by analyzing the latest evidence and guidelines. However, studies of concordance rate between WFO clinicians advanced gastric cancer (AGC) are lacking. Methods We retrospectively reviewed 65 patients with AGC who consulted Gachon Gil Medical Center multidisciplinary team (GMDT) in 2016 2017. The recommendations were compared opinions GMDT. provided three treatment options: recommended...
Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been reported to be related certain clinical characteristics (i.e., female, non-smokers with adenocarcinoma) and gefitinib responsiveness.This exploratory analysis was performed determine the incidence of EGFR male smokers squamous carcinoma, who were treated tyrosine kinase inhibitor, gefitinib.Sixty-nine Korean NSCLC patients a prospective study.For subset 20 carcinoma history smoking, pretreatment...
The aim of this study is to explore the association Ki-67 and p53 expression with prognosis in non-small cell lung cancer (NSCLC) patients who underwent curative resection. We retrospectively identified 116 consecutive stages I-III NSCLC resection at a single center from January 2007 December 2012. was assessed by immunohistochemistry. Data on clinicopathologic features survival were collected retrospectively. 109 samples 115 analyzed. According results, 108 (99 %) showed least some Ki-67....
Little is known about the efficacy of salvage chemotherapy for patients with metastatic, noncutaneous melanoma after failure dacarbazine-based chemotherapy. Because high incidence in Korea, we assessed outcomes paclitaxel/carboplatin (PC) metastatic melanoma. We retrospectively analyzed who received intravenous paclitaxel (175 mg/m2) plus carboplatin (area under curve 5) on day 1 a 21-day cycle as at Samsung Medical Center (SMC) between February 2009 and 2012. The overall response rate,...
To determine the prognostic significance of CT-determined cachexia scores (CSs) in 127 consecutive male small cell lung cancer (SCLC) patients, cross-sectional areas muscle and fat tissues at third lumbar vertebra (L3) were retrospectively measured on baseline CT images. CSs determined based presence sarcopenia and/or adipopenia. According to (L3 index <55 cm2 /m2 , 86.8%) adipopenia <22 11.8%), defined as follows: CS2 (sarcopenia adipopenia, CS1 only, 74.8%) CS0 (13.4%). was significantly...
Although emphysema is a known independent risk factor of lung cancer, no study has addressed the prognostic impact computed tomography (CT)-emphysema score in advanced stage cancer.For 84 consecutive patients with IIIB and IV squamous cell cancer that underwent palliative chemotherapy, severity was semi-quantitatively scored using baseline chest CT images according to Goddard scoring system (possible scores range, 0-24). The cutoff high CT-emphysema determined maximum chi-squared test...
For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered anecdotal reasons. This prospective study evaluated response either rotation or combination in uncontrolled pain. Patients suffering despite dose titration were randomly assigned group group. answered questionnaire that included items on severity (0 10) and interferences at baseline after one...
S-1 is an oral fluoropyrimidine consisting of the 5-fluorouracil prodrug tegafur combined with two modulating substances, gimeracil and potassium oxonate. On basis potential additive effect between mitomycin C (MMC) as a continuous infusion, we conducted phase II study to assess efficacy tolerability combination MMC second-line chemotherapy for advanced gastric cancer (AGC). Patients measurable AGC, progressive after one prior metastatic disease, received (7 mg/m2) on day 1 (40 twice daily...
This study was designed to determine the efficacy and safety of FOLFOX-4 chemotherapy as a salvage treatment for patients with advanced gastric cancer (AGC).The AGC an ECOG performance status 0~1 progressive disease after prior treatments were registered onto this phase II trial. The received oxaliplatin (85 mg/m² on day 1), leucovorin (200 days 1 2) 5-fluorouracil (400 bolus 600 22-hour infusion every 2 weeks.For 42 treated patients, total 228 cycles (median: 5, range: 1~12) administered....
In the past few years, number of clinical trials has increased rapidly in East Asia, especially for gastric and hepatobiliary cancer that are prevalent Asian populations. However, actual degree understanding or perceptions by patients countries have seldom been studied.Between July 1st November 30th 2011, we conducted a prospective study to survey regarding their awareness of, willingness participate in, trial. Patients with gastrointestinal/hepatobiliary who visited Hematology-Oncology...
Using a representative dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2011, we analyzed anthropometric dual-energy X-ray absorptiometry (DXA)-determined body composition findings for 493 cancer survivors (mean age a61.1 ± 12.6 years; 35.7% male). A much higher proportion of men (30.1%) than women (0.6%) met criteria sarcopenia. Subjects with history lung cancer, genitourinary or gastric were prone develop sarcopenia (31.6%, 26.3%, 21.4%,...
Recently, positron emission tomography (PET) has been incorporated into a series of prospective studies as predictor outcomes in multiple myeloma (MM), and the number <sup>18</sup>F-fluorodeoxuglucose (FDG)-avid focal lesions (FLs) intensity tumor metabolism have designated important surrogate markers for predicting prognosis. Here, we compared initial clinical characteristics MM patients with baseline PET parameters: FLs maximum standardized uptake value...