A5030633511- Chromatin Remodeling and Cancer
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Otitis Media and Relapsing Polychondritis
- Lung Cancer Research Studies
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- NF-κB Signaling Pathways
- Protein Degradation and Inhibitors
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Response and Inflammation
- Mechanisms of cancer metastasis
- Gene Regulatory Network Analysis
Guiyang Medical University
2025
University of Michigan
2017-2024
Jiangnan University
2024
University of Connecticut
2024
Chinese PLA General Hospital
2023
Michigan Medicine
2020
Michigan United
2020
Despite advancements in targeting the immune checkpoints program cell death protein 1 (PD-1), programmed ligand (PD-L1), and cytotoxic T lymphocyte–associated 4 (CTLA-4) for cancer immunotherapy, a large number of patients types remain unresponsive. Current immunotherapies focus on modulating an antitumor response by directly or indirectly expanding CD8 cells. A complementary strategy might involve inhibition Tregs that otherwise suppress responses. Here, we sought to identify functional...
Background/Aim: Head and neck cancer (HNC) is the sixth most common type of worldwide. While it widely accepted that human papillomavirus (HPV) infection a crucial risk factor for development this cancer, there still lack support from large-scale studies. This article addresses gap by comprehensively analyzing causal relationship between HPV head using Mendelian randomization methods. Patients Methods: The database was utilized to identify instrumental variables <i>via</i> enormous GWAS...
Preterm birth is a significant public health concern and exposure to phthalates has been shown be associated with an increased odds of preterm birth. Even modest reductions in gestational age at delivery could entail morbid consequences for the neonate analyzing data this additional information may useful. In present analysis, we consider as our outcome interest examine associations multiple phthalates. Women were recruited early pregnancy part prospective, longitudinal cohort Brigham...
mRNA therapeutics have garnered significant attention in the biomedical realm, showing immense potential across a spectrum of applications from COVID-19 to cancer treatments.Their ability trigger precise protein expression, particularly genome editing, is pivotal minimizing off-target effects.At core therapy lies dual-component system, comprising itself and delivery vehicle.The breakthrough success novel vaccines has catapulted lipid nanoparticles prominence as preferred vehicle.However,...
Background: Our previous studies have identified a serum-based 4-microRNA (4-miRNA) signature that may help distinguish patients with lung cancer (LC) from non-cancer controls (NCs). Here, we used an extended independent cohort of 398 subjects to further validate the diagnostic ability this 4-miRNA signature. Methods: Using quantitative reverse transcription polymerase chain reaction (qRT-PCR), expression 4-miRNAs was assessed in total sera included 213 LC and 185 NCs. A logistic regression...
Head and neck squamous cell carcinoma (HNSCC) is a common debilitating form of cancer characterized by poor patient outcomes low survival rates. In HNSCC, genetic aberrations in phosphatidylinositol 3-kinase (PI3K) epidermal growth factor receptor (EGFR) pathway genes are common, small molecules targeting these pathways have shown modest effects as monotherapies patients. Whereas emerging preclinical data support the combined use PI3K EGFR inhibitors in-human studies displayed limited...
Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive skull base tumor with poor survival limited treatment options. To date, targeted sequencing studies have identified IDH2 SMARCB1 as potential driver alterations, but the molecular alterations found in wild type tumors are unknown.We evaluated outcomes cohort of 46 SNUC patients treated at an NCI designated cancer center identify clinical disease variables associated on Kaplan-Meier Cox multivariate analysis. We performed...
The diagnosis of invasive pulmonary aspergillosis (IPA) increasingly relies on non-culture-based biomarkers in bronchoalveolar lavage (BAL) fluid. Aspergillus lateral flow device (LFD) is a rapid immunoassay that uses novel monoclonal antibody to gain specificity. objective the study compare specificity and sensitivity prototype LFD galactomannan (GM) enzyme BAL fluid high-risk patients. A total 114 samples from 106 patients at high risk for IPA were studied: 8 had proven/probable IPA, 16...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with poor survival rates, especially for cancers arising in the oral cavity or larynx. Cisplatin key chemotherapeutic HNSCC; however rates may be partially due to cisplatin resistance observed some HNSCCs. Here, we examined utility of genome-wide CRISPR knockout profiling nominating pivotal mechanisms HNSCC models. Methods We characterized sensitivity 18 lines. Next, used CRISPR/Cas9 library identify genes...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease with poor survival. Although epidermal growth factor receptor (EGFR)‐targeting antibody cetuximab improves survival in some settings, responses are limited suggesting that alternative approaches needed. Methods We performed high throughput drug screen to identify EGFR inhibitor‐based synergistic combinations of clinically advanced inhibitors models resistant inhibitor monotherapies, then downstream...
As immunotherapies targeting the PDL1 checkpoint have become a mainstay of treatment for subset head and neck squamous cell carcinoma (HNSCC) patients, detailed understanding mechanisms underlying PDL1-mediated immune evasion is needed. To elucidate factors regulating expression in HNSCC cells, genome-wide CRISPR profiling approach was implemented to identify genes pathways conferring altered an line model. Our screen nominated several candidate drivers, including Toll-like Receptor 2...
Objectives Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim this study is to advance methodology for a high-throughput drug screen using models identify new combination therapies chordoma. Study Design Present work an vitro study. Setting conducted at academic research laboratory. Materials and Methods An on automated screening cells was performed library 1,406 drugs as both mono- with PI3K...
Many real data analyses involve two-sample comparisons in location or distribution. Most existing methods focus on problems where observations are independently and identically distributed each group. However, some applications the observed not but associated with unobserved parameters which distributed. To address this challenge, we propose a novel testing procedure as combination of g$$ g $$ -modeling density estimation introduced by Efron Kolmogorov-Smirnov test. We also efficient...
Background: Our previous studies have identified a serum-based 4-microRNA signature that may help distinguish patients with lung cancer from non-cancer controls. Here, we used an extended independent cohort of 398 subjects to further validate the diagnostic ability this 4-miRNA signature. Methods: Using qRT-PCR, expression 4 miRNAs was assessed in total sera included 213 (LCs) and 185 controls (NCs). A logistic regression model using training-test sets, ROC curve analysis t-test were test...
The recent advancement in single-cell RNA sequencing technologies enables the understanding of dynamic cellular processes at level. Using trajectory inference methods, pseudotimes can be estimated based on reconstructed trajectories which further used to gain biological knowledge. Existing methods for modeling cell trajectories, such as minimal spanning tree or k-nearest neighbor graph, often lead locally optimal solutions. In this paper, we propose a penalized likelihood-based framework and...
Abstract Regulatory T (Treg) cells play an important role in modulating the tumor microenvironment, leading to suppression of anti-tumor immune responses. Tumor Tregs could be targeted by taking advantage differential expression checkpoints on these as compared other cell subsets. While elevated such CTLA-4 conventional is well-characterized, less known about collective landscape Treg specific checkpoint microenvironment. We identified a network Treg-associated markers including those...
Recent head and neck squamous cell carcinoma (HNSCC) sequencing studies have identified the phosphatidylinositol 3-kinase (PI3K) pathway as most frequently mutated, oncogenic in this cancer type. Despite frequent activating mutation or amplification PIK3CA (the gene encoding catalytic subunit of PI3K), targeted PI3K inhibitors shown limited clinical efficacy monotherapies. To identify factors that might predict sensitivity resistance to inhibitors, we tested a panel more than 40...
Abstract Recent head and neck squamous cell carcinoma (HNSCC) sequencing studies have identified the phosphatidylinositol 3-kinase (PI3K) pathway as most frequently mutated, oncogenic in this cancer type. Despite frequent activating mutation or amplification PIK3CA (the gene encoding catalytic subunit of PI3K), targeted PI3K inhibitors shown limited clinical efficacy monotherapies. To identify factors that might predict sensitivity resistance to inhibitors, we tested a panel more than 40...