A5003714391- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Lung Cancer Research Studies
- Escherichia coli research studies
- Herpesvirus Infections and Treatments
- Nitric Oxide and Endothelin Effects
- Hepatitis C virus research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunotherapy and Immune Responses
- Muscle and Compartmental Disorders
- Fungal Infections and Studies
- Heme Oxygenase-1 and Carbon Monoxide
University of Michigan
2018-2025
Michigan Medicine
2018-2024
Pulmonary and Critical Care Associates
2021
Ann Arbor VA Medical Center
2020
University of Colorado Anschutz Medical Campus
2007-2015
University of Colorado Denver
2006-2015
University of Colorado Health
2006-2015
Audie L. Murphy Memorial VA Hospital
2007
The University of Texas Health Science Center at San Antonio
2007
National Jewish Health
2006
We describe a case of proven transmission SARS-CoV-2 from lung donor to recipient. The had no clinical history or findings suggestive infection with and tested negative by reverse transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal (NP) swab obtained within 48 h procurement. Lower respiratory tract testing was not performed. recipient developed fever, hypotension, pulmonary infiltrates posttransplant day (PTD) 3, RT-PCR for an NP specimen non-reactive, but positive...
To determine the role of human metapneumovirus (HMPV) in respiratory tract infections (RTIs) lung transplant recipients, 60 patients were prospectively enrolled this study spanning from September 2005 to November 2007. Community-acquired viruses (CARVs) identified by polymerase chain reaction and tissue culture secretions. Of 112 RTIs, 51 associated with > or =1 CARV, including 7 HMPV, 13 syncytial virus (RSV), 19 parainfluenza 1, 2, 3 (PIV), 16 influenza A B (FLU), rhinoviruses (HRV)....
Evidence supports the use of 12 months cytomegalovirus prophylaxis in all at-risk lung transplants; whether serostatus can be used to further optimize this duration remains determined. The purpose retrospective study was determine if both donor and recipient were associated with late-onset cytomegalovirus. primary outcome proportion transplants that developed infection or disease during 180-day period following 6 each serotype. Two hundred forty-four consecutive evaluated, 131 included....
ABSTRACT Introduction Use of normothermic regional perfusion (NRP) to recover donation after circulatory death (DCD) organs demonstrates increased heart utilization with favorable outcomes. Conversely, DCD lung allograft use when NRP was employed remains controversial. This is a contemporary analysis recipient outcomes in which used. Methods Utilizing the STAR‐OPTN database, all adult recipients United States between January 1, 2020, and June 30, 2024 were identified. defined if time donor...
Rationale: Chronic lung allograft dysfunction (CLAD) results in significant morbidity after transplantation. Potential CLAD occurs when function declines to 80-90% of baseline. Better noninvasive tools prognosticate at potential are needed. Objectives: To determine whether parametric response mapping (PRM), a computed tomography (CT) voxel-wise methodology applied high-resolution CT scans, can identify patients risk progression or death. Methods: Radiographic features and PRM-based metrics...
Lung transplantation in the United States, under oversight by Organ Procurement Transplantation Network (OPTN) 1990s, operated a system of allocation based on location within geographic donor service areas, wait time potential recipients, and ABO compatibility. On May 4, 2005, lung score (LAS) was implemented OPTN Thoracic Committee to prioritize patients list balance mortality posttransplant survival, thus eliminating as factor prioritization. Patients were categorized into four main...
Abstract Although TGF-β inhibits the production of proinflammatory mediators in vitro and vivo, its anti-inflammatory activities may be ineffective early or severe acute inflammatory circumstances. In this study, we suggest a role for oxidative stress on signaling, leading to prevention normal effects but leaving Smad-driven cellular differentiation matrix unaffected. Stimulation RAW 264.7 macrophage cells, human mouse alveolar macrophages with LPS led NF-κB-driven mediators, which were...
Because of the high incidence morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this not universally effective may contribute to selection emerging, resistant pathogens. Here we present a rare case infection caused by Microascus trigonosporus species complex human, which developed during voriconazole lung recipient. Nebulized liposomal amphotericin B was addition systemic therapy order...
Human chorionic gonadotropin (hCG) is currently under investigation as an antigenic target in both anti-cancer and anti-fertility vaccines. Formulations studied to date show promise clinical trials for applications yet are expensive produce require frequent administration order maintain effective antibody titer. We have engineered a fusion protein consisting of Escherichia coli heat-labile enterotoxin subunit B (LTB) genetically linked at its C terminus via nine amino acid linker the 37...