A5073325161- Opioid Use Disorder Treatment
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Musculoskeletal pain and rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Genetic Associations and Epidemiology
- Spine and Intervertebral Disc Pathology
- Prenatal Substance Exposure Effects
- Pain Management and Placebo Effect
- Pharmaceutical Practices and Patient Outcomes
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Dental Anxiety and Anesthesia Techniques
- Nausea and vomiting management
- Aortic aneurysm repair treatments
- Gene expression and cancer classification
- Maternal Mental Health During Pregnancy and Postpartum
- BRCA gene mutations in cancer
- Shoulder Injury and Treatment
- COVID-19 and Mental Health
- Pain Management and Treatment
- Intensive Care Unit Cognitive Disorders
University of Michigan
2016-2025
Michigan Medicine
2016-2025
Institute for Healthcare Improvement
2021-2025
Michigan United
2018-2024
University of Iowa
2021-2023
University of North Carolina at Chapel Hill
2019-2023
Committee on Publication Ethics
2023
Beaumont Hospital, Royal Oak
2023
Ann Arbor Center for Independent Living
2016-2022
Pain and Headache Center
2017-2021
<h3>Importance</h3> Despite increased focus on reducing opioid prescribing for long-term pain, little is known regarding the incidence and risk factors persistent use after surgery. <h3>Objective</h3> To determine of new minor major surgical procedures. <h3>Design, Setting, Participants</h3> Using a nationwide insurance claims data set from 2013 to 2014, we identified US adults aged 18 64 years without in year prior surgery (ie, no prescription fulfillments 12 months 1 month procedure). For...
Few studies have assessed postoperative trends in opioid cessation and predictors of persistent use after total knee arthroplasty (TKA) hip (THA). Preoperatively, 574 TKA THA patients completed validated, self-report measures pain, functioning, mood were longitudinally for 6 months surgery. Among who naive the day surgery, 8.2% 4.3% using opioids at months. In comparison, 53.3% 34.7% reported surgery continued to Patients taking >60 mg oral morphine equivalents preoperatively had an 80%...
Despite efforts to reduce nonmedical opioid misuse, little is known about the development of persistent use after surgery among adolescents and young adults. We hypothesized that there an increased incidence prolonged refills adults who received prescription opioids compared with nonsurgical patients.We performed a retrospective cohort study by using commercial claims from Truven Health Marketscan research databases January 1, 2010, December 31, 2014. included opioid-naïve patients ages 13...
<h3>Importance</h3> There is growing evidence that opioids are overprescribed following surgery. Improving prescribing requires understanding factors associated with opioid consumption. <h3>Objective</h3> To describe and consumption for a variety of surgical procedures determine after <h3>Design, Setting, Participants</h3> A retrospective, population-based analysis the quantity prescribed patient-reported across 33 health systems in Michigan, using sample adults 18 years older undergoing...
The current study was designed to test the hypothesis that high-dose dexmedetomidine added local anesthetic would increase duration of sensory and motor blockade in a rat model sciatic nerve without causing damage.Thirty-one adult Sprague-Dawley rats received bilateral blocks with either 0.2 ml bupivacaine, 0.5%, 0.5% bupivacaine plus 0.005% contralateral extremity, or dexmedetomidine, 0.005%, normal saline extremity. Sensory function were assessed by blinded investigator every 30 min until...
Purpose The current epidemic of prescription opioid misuse has increased scrutiny postoperative prescribing. Some 6% to 8% opioid-naïve patients undergoing noncancer procedures develop new persistent use; however, it is unknown if a similar risk applies with cancer. We sought define the use after curative-intent surgery, identify factors, and describe changes in daily dose over time surgery. Methods Using national data set insurance claims, we identified cancer surgery from 2010 2014....
Peripheral nerve injuries represent a notable source of anesthetic complications and can be debilitating. The objective this study was to identify associations with peripheral injury in broad surgical population cared for the last decade.At tertiary care university hospital, quality assurance, closed claims, institution-wide billing code databases were searched over 10-yr period. Each reported case individually reviewed determine whether perioperative occurred, defined as new sensory and/or...
This interrupted time series analysis found significant changes in multiple dimensions of pain medication usage after the implementation postoperative opioid prescription guidelines a single hospital.
The current study was designed to test the hypothesis that increased duration of analgesia caused by adding dexmedetomidine local anesthetic results from blockade hyperpolarization-activated cation (I(h)) current.In this randomized, blinded, controlled study, analgesic effects peripheral nerve blocks using 0.5% ropivacaine alone or plus (34 μM 6 μg/kg) were assessed with without pretreatment α(1)- and α(2)-adrenoceptor antagonists (prazosin idazoxan, respectively) agonists I(h) (ZD 7288...
Opioid-associated morbidity and mortality are described by the Centers for Disease Control as a national “prescription painkiller overdose epidemic.”1 Today, 1 of every 25 adults regularly uses prescription opioid medications. Prescription use results in greater healthcare utilization associated expenditures, well increased rates owing to unintentional overdose, misuse, abuse, transition into heroin use.2,3 Nonetheless, one most common episodes prescribing is during perioperative period,...
Patterns of preoperative opioid use are not well characterized across different surgical services, and studies in this patient population have lacked important self-reported data pain affect.To assess the prevalence characteristics these patients a broadly representative cohort.Cross-sectional, observational study undergoing surgery at tertiary care academic medical center. Data were collected as part large prospective institutional research registries from March 1, 2010, through April 30,...
Objective: To explore the clinical and financial implications of preoperative opioid use in major abdominal surgery. Background: Opioids are increasingly used to manage chronic pain, users challenging care for perioperatively. Given epidemic opioid-related morbidity mortality, it is critical understand how impacts surgical outcomes. Methods: This was an analysis nonemergent, abdominopelvic surgeries from 2008 2014 a single center within Michigan Surgical Quality Collaborative registry...
Biobanks of linked clinical patient histories and biological samples are an efficient strategy to generate large cohorts for modern genetics research. Biobank recruitment varies by factors such as geographic catchment sampling strategy, which affect biobank demographics research utility. Here, we describe the Michigan Genomics Initiative (MGI), a single-health-system currently consisting >91,000 participants recruited primarily during surgical encounters at Medicine. The enrollment results...
Abstract Background: Variance in pain after total knee and hip arthroplasty may be due to a number of procedural peripheral factors but also, some individuals, aberrant central processing as is described conditions like fibromyalgia. To test this hypothesis, the authors conducted prospective, observational cohort study patients undergoing lower-extremity joint arthroplasty. Methods: Five hundred nineteen were preoperatively phenotyped using validated self-reported questionnaires,...
The current study was designed to test the hypothesis that dexmedetomidine added ropivacaine would increase duration of antinociception a thermal stimulus in dose-dependent fashion rat model sciatic nerve blockade.Fifty adult Sprague-Dawley rats (10 rats/group) received unilateral blocks with 0.2 ml (0.5%) or plus (2.7 microm [0.5 microg/kg], 11.7 [2 34.1 [6 120.6 [20 microg/kg]) randomized, blinded fashion. Time paw withdrawal latency for both paws and an assessment motor function were...