A5002189820- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Machine Learning in Healthcare
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Tracheal and airway disorders
- Surgical Simulation and Training
- Artificial Intelligence in Healthcare and Education
- Aortic aneurysm repair treatments
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Anesthesia and Pain Management
- COVID-19 and healthcare impacts
- Healthcare Operations and Scheduling Optimization
- Non-Invasive Vital Sign Monitoring
- Chronic Kidney Disease and Diabetes
- Electronic Health Records Systems
- Anesthesia and Neurotoxicity Research
University of Michigan
2016-2025
Michigan Medicine
2016-2025
Michigan United
2024
Ann Arbor VA Medical Center
2019-2023
Society of Cardiovascular Anesthesiologists
2023
Healthcare Technology Innovation Centre
2022
Ann Arbor Center for Independent Living
2016-2022
Novem (Netherlands)
2017-2022
American Society of Nephrology
2022
Society of Critical Care Medicine
2022
Five percent of adult patients undergoing noncardiac inpatient surgery experience a major pulmonary complication. The authors hypothesized that the choice neuromuscular blockade reversal (neostigmine vs. sugammadex) may be associated with lower incidence complications.
Patterns of preoperative opioid use are not well characterized across different surgical services, and studies in this patient population have lacked important self-reported data pain affect.To assess the prevalence characteristics these patients a broadly representative cohort.Cross-sectional, observational study undergoing surgery at tertiary care academic medical center. Data were collected as part large prospective institutional research registries from March 1, 2010, through April 30,...
Abstract Background Despite the significant healthcare impact of acute kidney injury, little is known regarding prevention. Single-center data have implicated hypotension in developing postoperative injury. The generalizability this finding and interaction between baseline patient disease burden remain unknown. authors sought to determine whether association intraoperative injury varies by preoperative risk. Methods Major noncardiac surgical procedures performed on adult patients across...
Background Although the estimated risk of life-threatening adverse respiratory events during supraglottic airway device use is rare, reported rate leading to failure 0.2-8%. Little known about risk-adjusted prediction Laryngeal Mask Airway requiring rescue tracheal intubation and its impact on patient outcomes. Methods All adult patients in whom a laryngeal mask (LMA Unique™, uLMA™; LMA North America, Inc., San Diego, CA) was used ambulatory nonambulatory anesthesia settings were included....
Compared with historic ventilation strategies, modern lung-protective includes lower tidal volumes (VT), driving pressures, and application of positive end-expiratory pressure (PEEP). The contributions each component to an overall intraoperative protective strategy aimed at reducing postoperative pulmonary complications have neither been adequately resolved, nor comprehensively evaluated within adult cardiac surgical population. authors hypothesized that a bundled was independently...
Abstract Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy aortopathy. Here we report genome-wide association scan of 466 BAV cases 4,660 age, sex ethnicity-matched controls with replication in up to 1,326 8,103 controls. We identify noncoding variant 151 kb from the gene encoding cardiac-specific transcription factor, GATA4, near-significance p.Ser377Gly GATA4 . was interrupted by CRISPR-Cas9 induced pluripotent stem cells...
Due to economic pressures and improvements in perioperative care, outpatient surgical procedures have become commonplace. However, risk factors for morbidity mortality remain unclear. There are no multicenter clinical data guiding patient selection surgery. The authors hypothesize that specific increase the likelihood of day case-eligible or mortality.The analyzed adults undergoing common by using American College Surgeons' National Surgical Quality Improvement Program database from 2005...
Abstract Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook genome-wide association study SCAD (N cases = 270/N controls 5,263) and identified replicated an rs12740679 at chromosome 1q21.2 ( P discovery+replication 2.19 × 10 −12 , OR 1.8) influencing ADAMTSL4 expression. Meta-analysis discovery replication samples associations with < 5 −8 6p24.1 PHACTR1 12q13.3 LRP1 females-only, 21q22.11 near...
Background Protective ventilation may improve outcomes after major surgery. However, in the context of one-lung ventilation, such a strategy is incompletely defined. The authors hypothesized that putative protective regimen would be independently associated with decreased odds pulmonary complications thoracic Methods merged Society Thoracic Surgeons Database and Multicenter Perioperative Outcomes Group intraoperative data for lung resection procedures using across five institutions from 2012...
Background: Thoracic aortic dissection is an emergent life-threatening condition. Routine screening for genetic variants causing thoracic not currently performed patients or family members. Methods: We whole exome sequencing of 240 with (n=235) rupture (n=5) and 258 controls matched age, sex, ancestry. Blinded to case-control status, we annotated in 11 genes pathogenicity. Results: Twenty-four pathogenic 6 (COL3A1, FBN1, LOX, PRKG1, SMAD3, TGFBR2) were identified 26 individuals, representing...
Abstract Background: Although predictors of laryngeal mask airway failure in adults have been elucidated, there remains a paucity data regarding children. Methods: The authors performed retrospective database review all pediatric patients who received anesthetic at their institution from 2006 to 2010. Device brands were restricted LMA Unique™ (Cardinal Health, Dublin, OH) and Classic™ (LMA North America, San Diego, CA), primary outcome was failure, defined as any event requiring device...
Objective: While rare variants in the COL5A1 gene have been associated with classical Ehlers-Danlos syndrome and rarely arterial dissections, recurrent underlying a systemic arteriopathy not described. Monogenic forms of multifocal fibromuscular dysplasia (mFMD) previously defined. Approach Results: We studied 4 independent probands pathogenic variant c.1540G>A, p.(Gly514Ser) who presented aneurysms, tortuosity, mFMD affecting multiple arteries. Arterial medial fibroplasia smooth muscle...