Lauren E. Petty
A5022981309- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Genetic Neurodegenerative Diseases
- Nutrition, Genetics, and Disease
- Stuttering Research and Treatment
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Phonetics and Phonology Research
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Reading and Literacy Development
- Genomics and Rare Diseases
- Pancreatic function and diabetes
- Language Development and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- dental development and anomalies
- Neuroscience and Music Perception
Vanderbilt University Medical Center
2018-2025
Vanderbilt University
2020-2025
The University of Texas Health Science Center at Houston
2015-2023
University of Pittsburgh
2023
Nashville Oncology Associates
2019
Institute of Neurological Sciences
2018
University of California, Los Angeles
2017-2018
National Research Council
2018
National Academies of Sciences, Engineering, and Medicine
2018
Neurobehavioral Systems
2018
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Genetic ataxias are associated with mutations in hundreds of genes high phenotypic overlap complicating the clinical diagnosis. Whole-exome sequencing (WES) has increased overall diagnostic rate considerably. However, upper limit this method remains ill-defined, hindering efforts to address remaining gap. To further assess role rare coding variation ataxic disorders, we reanalyzed our previously published exome cohort 76 predominantly adult and sporadic-onset patients, expanded total number...
Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals European ancestry. We a multiethnic genome-wide association study T2D among 53,102 cases 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, population groups the Population Architecture Genomics Epidemiology (PAGE) Diabetes Genetics Replication Meta-analysis (DIAGRAM) Consortia. In African ancestry, we discovered variant
Tooth agenesis is a common craniofacial abnormality in humans and represents failure to develop 1 or more permanent teeth. complex, variations about dozen genes have been reported as contributing the etiology. Here, we combined whole-exome sequencing, array-based genotyping, linkage analysis identify putative pathogenic variants candidate disease for tooth 10 multiplex Turkish families. Novel homozygous heterozygous LRP6, DKK1, LAMA3, COL17A1 genes, well known WNT10A, were identified likely...
Hispanics are disproportionately affected by NAFLD, liver fibrosis, cirrhosis, and HCC. Preventive strategies noninvasive means to identify those in this population at high risk for urgently needed. We aimed characterize the gut microbiome signatures related biological functions associated with fibrosis environmental genetic factors affecting them.
The gut microbiome composition varies across ethnicities and geographical locations, yet studies on diabetes-associated changes specific to high-risk Mexican Americans are lacking. Here, we aimed identify alterations associated with diabetes in this population, as well host genetic factors that may explain increased disease susceptibility ethnic group.
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent signals at significance (P<5×10 − 8 ) map 611 loci, of which 145 loci are previously unreported. define eight non-overlapping...
Abstract Uncovering the genetic underpinnings of musical ability and engagement is a foundational step for exploring their wide‐ranging associations with cognition, health, neurodevelopment. Prior studies have focused on using twin family designs, demonstrating moderate heritability phenotypes. The current study used genome‐wide complex trait analysis polygenic score (PGS) approaches utilizing genotype data to examine influences two musicality traits (rhythmic perception music engagement) in...
Polygenic severe obesity (body mass index [BMI] ≥40 kg/m2) has increased, especially in Hispanic/Latino populations, yet we know little about the underlying mechanistic pathways. We analyzed whole-blood multiomics data to identify genes differentially regulated Mexican Americans from Cameron County Hispanic Cohort. Our RNA sequencing analysis identified 124 significantly expressed between cases (BMI and controls <25 kg/m2); 33% replicated an independent sample same population. integrative...
This study aimed to identify cases of developmental stuttering and associated comorbidities in de-identified electronic health records (EHRs) at Vanderbilt University Medical Center, and, turn, build test a prediction model. A multi-step process including keyword search medical notes, text-mining algorithm, manual review was employed the EHR. Confirmed were compared matched controls phenotype code (phecode) enrichment analysis reveal conditions with (i.e., comorbidities). These phenotypes...
ABSTRACT We assembled an ancestrally diverse collection of genome-wide association studies type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). identified 277 loci at significance ( p <5×10 -8 ), including 237 attaining a more stringent trans-ancestry threshold -9 which were delineated to 338 distinct signals. Trans-ancestry meta-regression offered substantial enhancements fine-mapping, with 58.6% associations precisely localised due population...
Developmental stuttering is a speech disorder characterized by disruption in the forward movement of speech. This includes part-word and single-syllable repetitions, prolongations, involuntary tension that blocks syllables words, has life-time prevalence 6–12%. Within Vanderbilt's electronic health record (EHR)-linked biorepository (BioVU), only 142 individuals out 92,762 participants (0.15%) are identified with diagnostic ICD9/10 codes, suggesting large portion people who stutter do not...
Despite a lifetime prevalence of at least 5%, developmental stuttering, characterized by prolongations, blocks, and repetitions speech sounds, remains largely idiopathic disorder. Family, twin, segregation studies overwhelmingly support strong genetic influence on stuttering risk; however, its complex mode inheritance combined with thus-far underpowered contribute to the challenge identifying reproducing genes implicated in susceptibility. We conducted trans-ancestry genome-wide association...