A5024831282- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Birth, Development, and Health
- Stress Responses and Cortisol
- Neonatal Respiratory Health Research
- Histone Deacetylase Inhibitors Research
- Cholesterol and Lipid Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Peroxisome Proliferator-Activated Receptors
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
Vanderbilt University
2021-2024
Duke University
2021
Duke University Hospital
2021
Duke Medical Center
2021
University of Alabama at Birmingham
2015-2021
Mounting evidence has shown that CETP important physiological roles in adapting to chronic nutrient excess, specifically, protect against diet-induced insulin resistance. However, the underlying mechanisms for protective of metabolism are not yet clear. Mice naturally lack expression. We used transgenic mice with a human minigene (huCETP) controlled by its natural flanking region further understand CETP-related physiology response obesity. Female huCETP and their wild-type littermates were...
Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activities of NAD-dependent sirtuin deacetylase enzymes. This investigation examined impact NRS on whole body energy homeostasis, skeletal muscle corresponding shifts in acetyl-lysine proteome, context diet-induced obesity using C57BL/6NJ mice. The study also...
Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), largest source of human islets for research in U.S., provide standardized assessment islet preparations distributed to researchers, enabling integration multiple data types. Data from first 299 organ donors without diabetes, analyzed using this pipeline, highlights substantial heterogeneity cell composition associated with hormone secretory traits, sex, reported race ethnicity, genetically...
SUMMARY A hallmark of type 2 diabetes (T2D), a major cause world-wide morbidity and mortality, is dysfunction insulin-producing pancreatic islet β cells 1–3 . T2D genome-wide association studies (GWAS) have identified hundreds signals, mostly in the non-coding genome overlapping cell regulatory elements, but translating these into biological mechanisms has been challenging 4–6 To identify early disease-driving events, we performed single spatial proteomics, sorted transcriptomics, assessed...
Early life stress (ELS) is associated with cardiovascular disease (CVD) risk in adulthood, but the underlying vascular mechanisms are poorly understood. Increased hemoglobin and heme have recently been implicated to mediate endothelial dysfunction several diseases. Chronic physiological alterations pathway that well-described literature. However, very little known about exposure ELS or chronic psychosocial stress. Utilizing a mouse model of ELS, maternal separation early weaning (MSEW), we...
Early-life stress (ELS) is a major independent risk factor for cardiovascular disease (CVD). Recently, inflammatory acute-phase response (APR) proteins have been identified as novel markers of CVD; however, it unknown whether ELS induces APR. We hypothesized that vascular dysfunction and dysregulation APR proteins. Utilizing adult male control mice exposed to maternal separation with early weaning (MSEW), an model, we determined function macrophage infiltration well levels MSEW displayed...
The pancreatic islets of Langerhans, which are small 3D collections specialized endocrine and supporting cells interspersed throughout the pancreas, have a central role in control glucose homeostasis through secretion insulin by beta cells, lowers blood glucose, glucagon alpha raises glucose. Intracellular signaling pathways, including those mediated cAMP, key for regulated cell hormone secretion. islet structure, while essential coordinated function, presents experimental challenges...
The pancreatic islets of Langerhans, which are small 3D collections specialized endocrine and supporting cells interspersed throughout the pancreas, have a central role in control glucose homeostasis through secretion insulin by beta cells, lowers blood glucose, glucagon alpha raises glucose. Intracellular signaling pathways, including those mediated cAMP, key for regulated cell hormone secretion. islet structure, while essential coordinated function, presents experimental challenges...
Exposure to adverse childhood experiences, also known as early life stress (ELS), is an independent risk factor for the development of cardiovascular disease (CVD) in adulthood. Endothelial dysfunction a major contributor CVD and has been linked adversity induced risk. We previously reported circulating ET‐1 levels are significantly elevated young adults exposed humans. Endothelin‐1 (ET‐1) via ET A receptor promotes endothelial vascular inflammation. However, regulation by ELS mechanistic...
Early life stress (ELS) has been correlated with an increased risk of developing cardiovascular disease (CVD) in adulthood; however, mechanisms linking ELS and CVD are unknown. Toll‐like receptor (TLR) activation, specifically TLR4, implicated as a key link between inflammation CVD. TLR4 signaling can activated NADPH oxidases (NOXs) that produce superoxide to increase risk. Further, multiple studies have found NF‐kB important downstream step the pathway, requires activation certain NOX...
To determine the impact of autoimmunity in absence glycemic alterations on pregnancy type 1 diabetes (T1D).