A5059150622- Hemoglobinopathies and Related Disorders
- Nitric Oxide and Endothelin Effects
- Intracranial Aneurysms: Treatment and Complications
- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Vascular Malformations Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Pregnancy and preeclampsia studies
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Renin-Angiotensin System Studies
- CAR-T cell therapy research
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Trigeminal Neuralgia and Treatments
- Cardiovascular Health and Disease Prevention
- Circadian rhythm and melatonin
- Sodium Intake and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Birth, Development, and Health
- Synthetic Aperture Radar (SAR) Applications and Techniques
Barrow Neurological Institute
2020-2025
St. Joseph's Hospital and Medical Center
2021-2025
University of Alabama at Birmingham
2015-2024
The Ohio State University
2022-2023
The Ohio State University Wexner Medical Center
2022-2023
Prevention Institute
2013-2019
Augusta University
2014-2019
Metabolism and Renal Physiology
2017-2019
Wright State University
2018
Georgia Regents Medical Center
2014
Sickle cell disease (SCD)-associated nephropathy is a major source of morbidity and mortality in patients because the lack efficacious treatments targeting renal manifestations disease. Here, we describe long-term treatment strategy with selective endothelin-A receptor (ETA) antagonist, ambrisentan, designed to interfere development humanized mouse model SCD. Ambrisentan preserved GFR at level nondisease controls prevented proteinuria, albuminuria, nephrinuria. Microscopy studies...
INTRODUCTION: Thromboelastography (TEG) is a routine, relatively inexpensive blood test that measures the coagulative properties of sample. Previous studies have demonstrated its efficacy in predicting coagulation profiles patients with subarachnoid hemorrhage (SAH), however, relationship to neurological presentation and clinical outcome aneurysmal (aSAH) remains understudied. METHODS: We retrospectively identified 139 from July 2020 - September 2022 aSAH obtained TEGs without platelet...
Speed JS, Hyndman KA, Roth K, Heimlich JB, Kasztan M, Fox BM, Johnston JG, Becker BK, Jin C, Gamble KL, Young ME, Pollock DM. High dietary sodium causes dyssynchrony of the renal molecular clock in rats. Am J Physiol Renal 314: F89-F98, 2018. First published September 27, 2017; doi:10.1152/ajprenal.00028.2017.-Dyssynchrony circadian rhythms is associated with various disorders, including cardiovascular and metabolic diseases. The cell autonomous maintains control; however, environmental...
We previously reported that humanized sickle cell (HbSS) mice develop spontaneous nephropathy, a major cause of morbidity and mortality in disease (SCD). Because sex-dependent protective mechanisms SCD have been reported, we examined the course nephropathy male female HbSS to determine contributors and/or predictors severity. In mice, glomerular filtration rate was characterized by rapid onset hyperfiltration subsequent progressive decline renal function over 20 weeks. Early tubular injury...
BACKGROUND Extra-axial cavernous malformations (CMs) in the cerebellopontine angle (CPA) are rare, typically affect cranial nerves (CNs), and present significant therapeutic challenges. This report discusses case of a patient with an extra-axial CM CPA involving CN VII/VIII complex, alongside systematic review similar cases. OBSERVATIONS A literature search PubMed Embase databases identified 216 articles, 18 meeting inclusion criteria, encompassing 21 cases (average age 42.6 years). The most...
The present study tested the hypothesis that spontaneously hypertensive rats (SHR) have impaired nitric oxide synthase (NOS)-mediated regulation of vascular function versus Wistar-Kyoto (WKY). Aorta and small mesenteric arteries were studied from male female SHR (M F SHR) WKY WKY). Phenylephrine (PE)-induced vasoconstriction was greater in aorta M all others (P < 0.05); there neither sex nor strain differences PE contraction arteries. NOS inhibitor l-Nitro-Arginine Methyl Ester (l-NAME)...
The current study was designed to determine whether vascular endothelial-derived endothelin-1 (ET-1) is important for skin Na+ buffering. In control mice (C57BL/6J), plasma and osmolarity were significantly elevated in animals on high- vs. low-salt (HS LS, respectively) intake. increased associated with ET-1 mRNA tissue. There no detectable difference Na+:H2O HS fed (0.119 ± 0.005 mM 0.127 0.007 mM; LS HS); however, by blockade of the endothelin type A receptor ABT-627 (0.116 0.006 0.137 HS;...
Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, elevated in the blood plasma of both sickle patients mouse models disease. We show here that levels endothelin-1 its endothelin type A receptor are increased dorsal root ganglia model Pharmacologic inhibition or neuron-specific knockdown receptors primary sensory neurons alleviated basal post-hypoxia evoked hypersensitivities mice. Mechanistically, contribute to...
Acute psychosocial stress provokes increases in circulating endothelin-1 (ET-1) levels humans and animal models. However, key questions about the physiological function cellular source of stress-induced ET-1 remain unanswered. We hypothesized that endothelium-derived contributes to acute pressor response via activation endothelin A receptor.Adult male vascular endothelium-specific knockout mice control were homozygous for floxed allele exposed form cage switch (CSS), with blood pressure...
Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). may contribute to via inhibition nitric oxide (NO) bioavailability. Purpose . To determine if ingestion a single antioxidant cocktail (AOC) improves function in patients with CF. Methods In 18 CF (age 8-39 y), brachial artery flow-mediated dilation (FMD) was assessed using Doppler ultrasound prior two hours following either an AOC (<mml:math...
Background Approximately 3.2%–6% of the general population harbor an unruptured intracranial aneurysm (UIA). Ruptured aneurysms represent a significant healthcare burden, and preventing rupture relies on early detection treatment. Most patients with UIAs are asymptomatic, many symptoms associated nonspecific, which makes diagnosis challenging. This study explored UIAs, rate resolution such after microsurgical treatment, likely pathophysiology. Methods A retrospective review who underwent...
Preclinical data have demonstrated that heart rate (HR) can directly impact vascular endothelial function, in part, through a shear-stress mechanism. This study sought to explore, humans, the associations between resting and both shear function assessed by flow-mediated dilation (FMD). The brachial artery FMD test was performed 31 apparently healthy volunteers. Basal (B) hyperaemic (H) were quantified following two ways using from test: traditional cumulative area under curve up peak...
Reactive arthritis, or Reiter's disease, characteristically affects the joints of lower limbs in an asymmetrical pattern. Usually it does not affect cervical spine, and atlantoaxial subluxations are exception. This paper describes case HLA-B27-positive female patient with a sexually acquired reactive arthritis where non-reducible subluxation was present. The followed from age 27 to 41. By 38, anterior decompression cervico-medullary junction performed by transoral approach; second stage,...
Leptomeningeal metastasis is extremely rare in patients with ovarian cancer, but should be considered presenting neurologic deficits such as cauda equine syndrome. Given its poor prognosis and lack of data currently on management, additional studies are needed to optimize treatment regimens improve outcomes.
Abstract Intraventricular melanoma is a very rare and highly malignant disease. Safe resection the mainstay of treatment, but no standard guidelines exist for adjuvant therapy. Early histologic molecular diagnosis key improved survival.
•ICI-associated myocarditis is a rare clinical entity, but one with an exceedingly high mortality rate.•The condition can present wide variety of manifestations. Thus, suspicion for the diagnosis should remain elevated in at-risk patients receiving immunotherapy.•Early and prompt initiation high-dose steroids are key to optimizing patient outcomes.