A5067918792- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Photoreceptor and optogenetics research
- Sleep and related disorders
- Diet and metabolism studies
- Sleep and Work-Related Fatigue
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Neurobiology and Insect Physiology Research
- Electromagnetic Fields and Biological Effects
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neurological disorders and treatments
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
University of Alabama at Birmingham
2016-2025
Portsmouth Hospitals NHS Trust
2015-2023
Behavioral Pharma (United States)
2010-2021
Queen Alexandra Hospital
2020
Karen Hospital
2019
Vanderbilt University
2005-2012
Samford University
2011
Georgia State University
2003-2006
Center for Neurosciences
2006
Circadian rhythms modulate nearly every mammalian physiological process. Chronic disruption of circadian timing in shift work or during chronic jet lag animal models leads to a higher risk several pathologies. Many these conditions both workers and experimental share the common factor inflammation. In this study, we show that experimentally induced altered innate immune responses. Endotoxemic shock by LPS was magnified, leading hypothermia death after four consecutive weekly 6-h phase...
Dopamine is a key neuromodulator in the retina and brain that supports motor, cognitive, visual function. Here, we developed mouse model on C57 background which expression of rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase, specifically disrupted retina. This enabled assessment overall role retinal vision using electrophysiological (electroretinogram), psychophysical (optokinetic tracking), pharmacological techniques. Significant disruptions were observed high-resolution,...
Aggregates of α-synuclein (α-syn) accumulate in neurons Parkinson's disease and other synucleinopathies. These inclusions predominantly localize to axons even the early stages disease, but their affect on axon function has remained unknown. Previously we established a model which addition preformed α-syn fibrils primary seeds formation insoluble built from endogenously expressed that closely recapitulate neuropathological phenotypes Lewy neurites found human diseased brains. Here show, using...
Circadian clocks are cell autonomous, transcriptionally based, molecular mechanisms that confer the selective advantage of anticipation, enabling cells/organs to respond environmental factors in a temporally appropriate manner. Critical circadian clock function 2 transcription factors, CLOCK and BMAL1. The purpose present study was reveal novel physiologic functions BMAL1 heart, as well determine pathologic consequences chronic disruption this component. To address goal, we generated...
Background Daily cycles of sleep/wake, hormones, and physiological processes are often misaligned with behavioral patterns during shift work, leading to an increased risk developing cardiovascular/metabolic/gastrointestinal disorders, some types cancer, mental disorders including depression anxiety. It is unclear how sleep timing, chronotype, circadian clock gene variation contribute adaptation work. Methods Newly defined strategies, genotype for polymorphisms in genes were assessed 388...
REVIEW article Front. Endocrinol., 07 August 2013 | https://doi.org/10.3389/fendo.2013.00092
The cardiomyocyte circadian clock directly regulates multiple myocardial functions in a time-of-day-dependent manner, including gene expression, metabolism, contractility, and ischemic tolerance. These same biological processes are also influenced by modification of proteins monosaccharides O-linked β-N-acetylglucosamine (O-GlcNAc). Because the protein O-GlcNAcylation have common regulatory roles heart, we hypothesized that relationship exists between two. We report total cardiac O-GlcNAc...
Abstract This White Paper presents the results from a workshop cosponsored by Sleep Research Society (SRS) and for on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians circadian rhythm researchers identify existing gaps in diagnosis treatment areas of high-priority research sleep–wake disorders (CRSWD). CRSWD are distinct class caused alterations time-keeping system, its entrainment mechanisms, or misalignment endogenous external environment. In these disorders,...
Circadian dyssynchrony of an organism (at the whole-body level) with its environment, either through light-dark (LD) cycle or genetic manipulation clock genes, augments various cardiometabolic diseases. The cardiomyocyte circadian has recently been shown to influence multiple myocardial processes, ranging from transcriptional regulation and energy metabolism contractile function. authors, therefore, reasoned that chronic dyssychrony environment would precipitate maladaptation a challenge...
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensory-motor neurological disorder with circadian component. RLS characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms BTBD9, along three other genes, being associated higher risk of RLS. Little about function BTBD9 its potential role...
Chronic ethanol consumption disrupts several metabolic pathways including β-oxidation and lipid biosynthesis, facilitating the development of alcoholic fatty liver disease. Many these same are directly regulated by cell autonomous circadian clocks, recent studies suggest that disruption daily rhythms in metabolism contributes to multiple common cardiometabolic diseases (including non-alcoholic disease). However, it is not known whether core molecular clock liver, nor this, turn, alters...
Circadian rhythmicity in the primary mammalian circadian pacemaker, suprachiasmatic nucleus (SCN) of hypothalamus, is maintained by transcriptional and translational feedback loops among clock genes. Photic resetting SCN pacemaker involves induction genes Period1 ( Per1 ) Period2 Per2 communication distinct cell populations. Gastrin-releasing peptide (GRP) localized to ventral retinorecipient zone, from where it may communicate photic signals within network. Here, we tested putative role GRP...
Patients with attention-deficit/hyperactivity disorder (ADHD) often exhibit disrupted sleep and circadian rhythms. Determination of whether disturbance and/or disruption are differentially associated symptom severity is necessary to guide development future treatment strategies. Therefore, we measured ADHD symptoms in participants aged 19–65 who met the DSM-IV-TR (Diagnostic Statistical Manual Mental Disorders, Fourth Edition, Text Revision) criteria for insomnia without psychiatric...
Circadian misalignment between sleep and behavioral/feeding rhythms is thought to lead various health impairments in shift workers. Therefore, we investigated how work leads genome-wide circadian dysregulation hospital nurses. Female nurses from the University of Alabama at Birmingham (UAB) Hospital working night ( n = 9; 29.6 ± 11.4 y) day 8; 34.9 9.4 participated a 9-day study measuring locomotor activity core body temperature (CBT) continuously. Additionally, cortisol melatonin were...
Hippocampal rhythms in clock gene expression, enzymatic activity, and long-term potentiation (LTP) are thought to underlie day-night differences memory acquisition recall. Glycogen synthase kinase 3-beta (GSK3β) is a known regulator of hippocampal function, inhibitory phosphorylation GSK3β exhibits region-specific over the light-dark cycle. Here, we sought determine whether both GSK3α isoforms has an endogenous circadian rhythm specific areas hippocampus chronic inhibition or activation...
Abstract How neurons encode intracellular biochemical signalling cascades into electrical signals is not fully understood. Neurons in the central circadian clock mammals provide a model system to investigate encoding of timing signals. Here, using experimental and modelling approaches, we show how activation glycogen synthase kinase 3 (GSK3) contributes neuronal excitability through regulation persistent sodium current ( I NaP ). exhibits day/night difference peak magnitude regulated by...
Abstract Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing entrains circadian rhythms blood pressure (BP) and renal excretion mice. Male C57BL/6J mice were fed ad libitum or reverse feeding (RF) where was available at all times day only during the 12-h lights-on period, respectively. Mice eating had significantly higher mean arterial (MAP) lights-off compared to (113 ± 2 mmHg vs 100 mmHg, respectively; P <...