A5090817416- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Obstructive Sleep Apnea Research
- Housing Market and Economics
- Spaceflight effects on biology
- Neuroscience of respiration and sleep
- Migraine and Headache Studies
- Restless Legs Syndrome Research
- Fiscal Policy and Economic Growth
- Financial Literacy, Pension, Retirement Analysis
- Olfactory and Sensory Function Studies
- Human-Automation Interaction and Safety
- Ergonomics and Musculoskeletal Disorders
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Youth Substance Use and School Attendance
- Music Therapy and Health
- Insurance and Financial Risk Management
- Body Composition Measurement Techniques
Rush University Medical Center
2014-2025
University of Northampton
2021-2022
Circadian (United States)
1996-2021
Climate Foundation
2021
Rush University
2008-2018
Chest Medicine Associates
2018
Royal Institution of Chartered Surveyors
2016-2017
Brigham and Women's Hospital
1996-2011
Harvard University
1996-2011
Presbyterian St. Luke's Medical Center
2002-2003
The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than men, even when the men maintain nearly identical consistent bedtimes wake times. Moreover, tend up exhibit a greater preference for morning activities men. Although neurobiological mechanism underlying this sex difference alignment is unknown, multiple studies nonhuman animals have demonstrated period that could account such between Whether intrinsic humans underlies unknown. We analyzed precise...
The interaction of homeostatic and circadian processes in the regulation waking neurobehavioral functions sleep was studied six healthy young subjects. Subjects were scheduled to 15–24 repetitions a 20-h rest/activity cycle, resulting desynchrony between sleep-wake cycle rhythms body temperature melatonin. components cognitive throughput, short-term memory, alertness, psychomotor vigilance, disruption at peak levels near maximum, shortly before melatonin secretion onset. These measures...
To evaluate the efficacy of mindfulness meditation for treatment chronic insomnia.Three-arm, single-site, randomized controlled trial.Academic medical center.Fifty-four adults with insomnia.Participants were to either mindfulness-based stress reduction (MBSR), therapy insomnia (MBTI), or an eight-week self-monitoring (SM) condition.Patient-reported outcome measures total wake time (TWT) from sleep diaries, pre-sleep arousal scale (PSAS), measuring a prominent waking correlate insomnia, and...
The aim of this study was to quantify the associations between slow eye movements (SEMs), blink rate, waking electroencephalogram (EEG) power density, neurobehavioral performance, and circadian rhythm plasma melatonin in a cohort 10 healthy men during up 32 h sustained wakefulness. time course performance characterized by fairly stable levels throughout first 16 wakefulness followed deterioration phase secretion. This closely associated with an increase SEMs. Frontal low-frequency EEG...
Summary Alertness and performance on a wide variety of tasks are impaired immediately upon waking from sleep due to inertia, which has been found dissipate in an asymptotic manner following waketime. It suggested that behavioural or environmental factors, as well stage at awakening, may affect the severity inertia. In order determine time course inertia dissipation under normal entrained conditions, subjective alertness cognitive throughput were measured during first 4 h after habitual...
Sleep, circadian rhythm, and neurobehavioral performance measures were obtained in five astronauts before, during, after 16-day or 10-day space missions. In space, scheduled rest-activity cycles 20–35 min shorter than 24 h. Light-dark highly variable on the flight deck, daytime illuminances other compartments of spacecraft very low (5.0–79.4 lx). amplitude body temperature rhythm was reduced urinary cortisol appeared misaligned relative to imposed non-24-h sleep-wake schedule....
The cumulative effects of chronic sleep loss may be overcome at certain times day, but the residual deprivation profoundly degrade performance and thereby compromise safety.
Objective:To investigate whether the effectiveness of a novel high-frequency low-dose caffeine regimen in counteracting deterioration performance during extended wakefulness is related to its interaction with homeostatic or circadian signals modulating and sleep propensity.
To investigate the effects of a physiologic and pharmacologic dose exogenous melatonin on sleep latency efficiency in episodes initiated across full range circadian phases. Design: Double-blind placebo-controlled parallel-group design 27-day forced desynchrony paradigm with 20-hour scheduled sleep-wake cycle. Private suite general clinical research center, absence time-of-day information. Thirty-six healthy, 18- to 30-year-old, men (n = 21) women 15). Oral (0.3 mg or 5.0 mg)...
To examine the relationship between hypertension prevalence in individuals with insomnia who have short total sleep duration < 6 h or ≥ h, using both objective and subjective measures of duration.Using a cross-sectional, observational design, 255 adult volunteers (n = 165 women; 64.7%) meeting current diagnostic criteria for disorder (MAge 46.2 y, SDAge 13.7 y) participated this study at two large university medical centers. Two nights polysomnography, 2 w diaries, questionnaires focused on...
There is a need for the accurate assessment of circadian phase outside clinic/laboratory, particularly with gold standard dim light melatonin onset (DLMO). We tested novel kit designed to assist in saliva sampling at home later determination DLMO. The includes objective measures compliance requirements and half-hourly sampling. Participants were randomized one two 10-day protocols. Each protocol consisted back-to-back laboratory assessments counterbalanced order, separated by 5-day break....
Abstract This White Paper presents the results from a workshop cosponsored by Sleep Research Society (SRS) and for on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians circadian rhythm researchers identify existing gaps in diagnosis treatment areas of high-priority research sleep–wake disorders (CRSWD). CRSWD are distinct class caused alterations time-keeping system, its entrainment mechanisms, or misalignment endogenous external environment. In these disorders,...
To assess circadian and homeostatic influences on subjective sleepiness cognitive performance in older adults when sleep waking are scheduled at different times of day; to changes across several weeks an inpatient study; compare these findings with results from younger adults.Three 24-h baseline days consisting 16 h wakefulness 8-h opportunity followed by 3-beat cycles a 20-h forced desynchrony (FD) condition; 18 "days," each 13.33 6.67 opportunity.Intensive Physiological Monitoring Unit the...
To investigate treatment models using cognitive behavioral therapy for insomnia (CBT-I) and positive airway pressure (PAP) people with obstructive sleep apnea (OSA) comorbid insomnia.
Summary The dim light melatonin onset ( DLMO ) assists with the diagnosis and treatment of circadian rhythm sleep disorders. Home s are attractive for cost savings convenience, but can be confounded by home lighting sample timing errors. We developed a saliva collection kit objective measures exposure timing. report on our first test in clinical population. Thirty‐two participants delayed phase disorder DSPD ; 17 women, aged 18–52 years) participated two back‐to‐back laboratory assessments....
Study Objectives:To assess temporal stability across multiple assessments and predictors of circadian phase in participants with delayed sleep syndrome (DSPS), relative to normal-sleeping matched controls.
Sleep restriction causes impaired cognitive performance that can result in adverse consequences many occupational settings. Individuals may rely on self-perceived alertness to decide if they are able adequately perform a task. It is therefore important determine the relationship between an individual's self-assessed and their objective performance, how this depends circadian phase, hours since awakening, cumulative lost of sleep. Healthy young adults (aged 18–34) completed inpatient schedule...