A5053904823- Endodontics and Root Canal Treatments
- Cleft Lip and Palate Research
- dental development and anomalies
- Dental Radiography and Imaging
- Oral microbiology and periodontitis research
- Craniofacial Disorders and Treatments
- Bone and Dental Protein Studies
- Pleural and Pulmonary Diseases
- Congenital Ear and Nasal Anomalies
- Dental Trauma and Treatments
- Oral and Maxillofacial Pathology
- Airway Management and Intubation Techniques
- Dental materials and restorations
- Bone Metabolism and Diseases
- Oral Health Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Clinical practice guidelines implementation
- Intramuscular injections and effects
- Plant-based Medicinal Research
- Advances in Oncology and Radiotherapy
- Dental Research and COVID-19
- Cancer-related gene regulation
- Dental Health and Care Utilization
- Inflammatory mediators and NSAID effects
University of Pittsburgh
2009-2025
The University of Texas Health Science Center at Houston
2014-2023
American Dental Education Association
2023
Columbia University
2022-2023
John Wiley & Sons (United States)
2019-2023
Research Network (United States)
2021
Association for Women in Science
2019
Triangle
2019
Indianapolis Zoo
2019
Kentucky Science Center
2019
Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used development to subphenotype the goal of identifying cleft subgroups that could have specific genetic contributions. examined 1000 individuals, 500 and without. several clinical features, such as completeness or incompleteness, laterality, presence assess each individual’s status. performed chi-square Fisher’s exact tests compare frequencies observed between clefts, among different...
There is evidence for a genetic component in caries susceptibility, but the disease greatly influenced by environmental factors, which are extremely difficult to control humans. For present study, we used DNA samples collected from 110 unrelated, non-cleft individuals older than 12 years of age Tiquisate, Guatemala: population with similar cultural, dietary and hygiene habits, access dentist fluoride exposure. Forty-four were designated ‘very low experience’ (DMFT ≤2), 66 ‘higher ≧3)....
Previous studies demonstrate that the balance between pro- and anti-inflammatory mediators determines stable or progressive nature of periapical granulomas by modulating osteoclastogenic factor RANKL its antagonist OPG. However, cytokine networks operating in development lesions are quite more complex than what simple versus mediators' paradigm suggests. Here we simultaneously investigated patterns Th1, Th2, Th9, Th17, Th22, Thf, Tr1 Tregs cytokines/markers expression human granulomas....
Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars incisors. These defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic environmental factors have been suggested play roles MIH’s development, but no conclusive risk shown source disease. During head neck interferon...
Avulsions are very common in a school setting. Teachers often requested to help such emergency situations. A survey consisting of seven simple questions regarding dental avulsion was answered by 60 teachers from five different elementary schools Rio de Janeiro, Brazil, order evaluate their knowledge on the subject and establish guideline be followed when an accident this type happens. lack technical information observed among teachers; most them intuitively rather than informative basis....
Abstract BACKGROUND: AXIN2 and CDH1 genes play important roles during craniofacial morphogenesis. Mutations in these have been described families presenting colorectal cancer tooth agenesis, gastric cleft lip/palate (CL/P). Oral clefts associated with agenesis. We investigated if polymorphisms were or any dental subphenotypes. METHODS: Markers genotyped using Taqman chemistry a sample cohort comprised of 500 individuals unrelated controls. RESULTS: Comparison between control groups showed...
Abstract BACKGROUND Clefts of the lip and/or palate (cleft lip/palate) are notable for their complex etiology. The WNT pathway regulates multiple developmental processes including craniofacial development and may play a role in cleft lip/palate other defects such as tooth agenesis. Variations genes have been recently associated with humans. In addition, two genes, Wnt3 Wnt9B , located clf1 locus mice. METHODS We investigated 13 SNPs Wnt3A, Wnt5A, Wnt8A, Wnt11, association subphenotypes 463...
Abstract Aim To evaluate the cytotoxic effects of triple antibiotic paste ( TAP ), double DAP minocycline and calcium hydroxide their influence on cytokine m RNA expression levels human periodontal ligament HPDL ) fibroblasts. Methodology Triple paste, Ca(OH) 2 test samples were immersed in culture medium incubated at 37 °C for 24 48 h. cells seeded a density × 10 4 exposed to either media (negative control), 0.1% SDS (positive 24‐ or 48‐h elutes each material A multiparametric cytotoxicity...
Tooth agenesis is a common craniofacial abnormality in humans and represents failure to develop 1 or more permanent teeth. complex, variations about dozen genes have been reported as contributing the etiology. Here, we combined whole-exome sequencing, array-based genotyping, linkage analysis identify putative pathogenic variants candidate disease for tooth 10 multiplex Turkish families. Novel homozygous heterozygous LRP6, DKK1, LAMA3, COL17A1 genes, well known WNT10A, were identified likely...
Objective RetroMTA® is a new hydraulic bioceramic indicated for pulp capping, perforations or root resorption repair, apexification and apical surgery. The aim of this study was to compare the radiopacity, pH variation cytotoxicity material ProRoot® MTA. Material Methods Mixed cements were exposed digital x-ray along with an aluminum stepwedge radiopacity assay. values verified after incubation period 3, 24, 48, 72 168 hours. each cement tested on human periodontal ligament fibroblasts using...
The chronic inflammatory immune response triggered by the infection of tooth root canal system results in local upregulation RANKL, resulting periapical bone loss. While RANKL has a well-characterized role control homeostasis/pathology, it can play important roles regulation system, although its possible immunoregulatory infectious osteolytic conditions remains largely unknown. Here, we used mouse model lesions subjected to continuous or transitory anti-RANKL inhibition, followed analysis...